{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:29:55Z","timestamp":1776281395613,"version":"3.50.1"},"reference-count":55,"publisher":"Bioscientifica","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The <jats:italic>Li\u00e8ge Acromegaly Survey (LAS) Database<\/jats:italic>, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The following results were obtained at diagnosis. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs 46.4 years; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The median delay from first symptoms to diagnosis was 2 years longer in females (<jats:italic>P<\/jats:italic>\u2009=\u20090.015). Ages at diagnosis and first symptoms increased significantly over time (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Tumors were larger in males than females (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); tumor size and invasion were inversely related to patient age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). GH was inversely related to age in both sexes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in &lt;5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6\u20134.4% had experienced a fracture. In conclusion, this study of &gt;3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis.<\/jats:p>","DOI":"10.1530\/erc-17-0253","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T00:20:19Z","timestamp":1500682819000},"page":"505-518","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":219,"title":["Acromegaly at diagnosis in 3173 patients from the Li\u00e8ge Acromegaly Survey (LAS) Database"],"prefix":"10.1530","volume":"24","author":[{"given":"Patrick","family":"Petrossians","sequence":"first","affiliation":[{"name":"Department of Endocrinology, CHU de Li\u00e8ge, University of Li\u00e8ge, Belgium"}]},{"given":"Adrian F","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, CHU de Li\u00e8ge, University of Li\u00e8ge, Belgium"}]},{"given":"Emil","family":"Natchev","sequence":"additional","affiliation":[{"name":"Clinical Centre of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria"}]},{"given":"Luigi","family":"Maione","sequence":"additional","affiliation":[{"name":"APHP Endocrinology and Reproductive Diseases, Paris Sud University, Le Kremlin-Bic\u00eatre, France"}]},{"given":"Karin","family":"Blijdorp","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"given":"Mona","family":"Sahnoun-Fathallah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre de R\u00e9f\u00e9rence des Maladies Rares d\u2019Origine Hypophysaire, H\u00f4pital de la Timone, Marseille, France"}]},{"given":"Renata","family":"Auriemma","sequence":"additional","affiliation":[{"name":"Dipartimento Di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University \u201cFederico II\u201d, Naples, Italy"}]},{"given":"Alpha M","family":"Diallo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, CHU de Reims, France"}]},{"given":"Anna-Lena","family":"Hulting","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden"}]},{"given":"Diego","family":"Ferone","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Genoa, Genova, Italy"}]},{"given":"Vaclav","family":"Hana","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic"}]},{"given":"Silvia","family":"Filipponi","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy and Neuromed, IRCCS, Pozzilli, Italy"}]},{"given":"Caroline","family":"Sievers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology and Clinical Chemistry, Max Planck Institute of Psychiatry, Munich, Germany"}]},{"given":"Claudia","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology, Diabetes and Metabolism Unit, Centro Hospitalar de Tr\u00e1s-os-Montes e Alto Douro, Portugal"}]},{"given":"Carmen","family":"Fajardo-Monta\u00f1ana","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario de la Ribera, Alzira, Spain"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar S. Jo\u00e3o, Faculty of Medicine, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, University of Porto, Porto, Portugal"}]},{"given":"Vaclav","family":"Hana","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic"}]},{"given":"G\u00fcnter K","family":"Stalla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology and Clinical Chemistry, Max Planck Institute of Psychiatry, Munich, Germany"}]},{"given":"Marie-Lise","family":"Jaffrain-R\u00e9a","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy and Neuromed, IRCCS, Pozzilli, Italy"}]},{"given":"Brigitte","family":"Delemer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, CHU de Reims, France"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[{"name":"Dipartimento Di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University \u201cFederico II\u201d, Naples, Italy"}]},{"given":"Thierry","family":"Brue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre de R\u00e9f\u00e9rence des Maladies Rares d\u2019Origine Hypophysaire, H\u00f4pital de la Timone, Marseille, France"}]},{"given":"Sebastian J C M M","family":"Neggers","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"given":"Sabina","family":"Zacharieva","sequence":"additional","affiliation":[{"name":"Clinical Centre of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"APHP Endocrinology and Reproductive Diseases, Paris Sud University, Le Kremlin-Bic\u00eatre, France"}]},{"given":"Albert","family":"Beckers","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, CHU de Li\u00e8ge, University of Li\u00e8ge, Belgium"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1324","article-title":"Divergence between growth hormone and insulin-like growth factor-i concentrations in the follow-up of acromegaly","volume":"93","author":"Alexopoulou","year":"2008","unstructured":"Alexopoulou O Bex M Abs R T\u2019Sjoen G Velkeniers B Maiter D 2008 Divergence between growth hormone and insulin-like growth factor-i concentrations in the follow-up of acromegaly. 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