{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:02:06Z","timestamp":1777309326054,"version":"3.51.4"},"reference-count":131,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,23]]},"abstract":"<jats:p>With the widespread use of sensitive imaging techniques, which include neck visualization, a conspicuous number of thyroid nodules emerge and demand attention. Most lesions are benign, asymptomatic, and do not warrant treatment. In the case of cancer diagnosis, most are small, intrathyroidal and indolent neoplasms that can safely be managed conservatively. There is a pronounced need for more cost-effective, risk-adapted approaches to the management of this highly prevalent condition, taking the wishes of the patient into consideration. Thus, the present guidelines aim at providing a clinical practice guide for the initial workup and the subsequent management of adult individuals harboring thyroid nodules. Importantly, these guidelines are not intended to cover the management of thyroid malignancy. The manuscript and the specific recommendations were developed by reconciling the best available research evidence with the knowledge and clinical experience of the panelists and updating aspects of a number of previous European Thyroid Association guidelines.<\/jats:p>","DOI":"10.1530\/etj-23-0067","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T10:54:06Z","timestamp":1687776846000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":312,"title":["2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management"],"prefix":"10.1530","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-5915","authenticated-orcid":true,"given":"Cosimo","family":"Durante","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9691-7619","authenticated-orcid":true,"given":"Laszlo","family":"Heged\u00fcs","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}]},{"given":"Agnieszka","family":"Czarniecka","sequence":"additional","affiliation":[{"name":"M. Sklodowska-Curie National Research, Institute of Oncology Gliwice Branch, Gliwice, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-268X","authenticated-orcid":true,"given":"Ralf","family":"Paschke","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8036-6050","authenticated-orcid":true,"given":"Gilles","family":"Russ","sequence":"additional","affiliation":[{"name":"Thyroid and Endocrine Tumors Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Sorbonne University GRC N\u00b016, Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-6946","authenticated-orcid":true,"given":"Fernando","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of University of Porto, CINTESIS@RISE and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":true,"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute of Investigation and Innovation in Health (I3S), Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Tamas","family":"Solymosi","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Clinic, Bugat Hospital, Gy\u00f6ngy\u00f6s, Hungary"}]},{"given":"Enrico","family":"Papini","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Regina Apostolorum Hospital, Albano, Rome, Italy"}]}],"member":"416","reference":[{"key":"bib1","series-title":"European Journal of Clinical Investigation","first-page":"699","article-title":"Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination","volume":"39","author":"Guth","year":"2009","unstructured":"Guth STheune UAberle JGalach A & Bamberger CM. 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