{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:56:21Z","timestamp":1770335781193,"version":"3.49.0"},"reference-count":174,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:p>\n                    This review examines the emerging roles of\n                    <jats:italic>DICER1<\/jats:italic>\n                    and\n                    <jats:italic>DGCR8<\/jats:italic>\n                    , key components of the miRNA biogenesis pathway, in thyroid pathogenesis, with a particular focus on their association with oncocytic morphology. Recent findings have expanded our understanding of DICER1 syndrome and\n                    <jats:italic>DGCR8<\/jats:italic>\n                    -related thyroid disorders, revealing a broader spectrum of thyroid lesions associated with mutations in these genes than previously recognised. We analyse the current literature on\n                    <jats:italic>DICER1<\/jats:italic>\n                    and\n                    <jats:italic>DGCR8<\/jats:italic>\n                    mutations in thyroid pathology, synthesising data from both basic science and pathological studies. The review explores recent findings on oncocytic features in some\n                    <jats:italic>DICER1<\/jats:italic>\n                    -mutated thyroid lesions, acknowledging that this association remains under investigation. The manuscript details the molecular mechanisms underlying\n                    <jats:italic>DICER1<\/jats:italic>\n                    and\n                    <jats:italic>DGCR8<\/jats:italic>\n                    mutations, including their impact on miRNA processing and subsequent effects on gene expression and cellular function. We discuss the diverse range of thyroid lesions associated with these mutations, from benign follicular nodular disease to aggressive carcinomas. The clinical implications of these findings are significant, as recognising\n                    <jats:italic>DICER1<\/jats:italic>\n                    and\n                    <jats:italic>DGCR8<\/jats:italic>\n                    -related thyroid lesions can lead to improved patient management, including genetic counselling and surveillance for other associated malignancies. We propose an algorithm for identifying\n                    <jats:italic>DICER1<\/jats:italic>\n                    -related thyroid lesions, with a focus on oncocytic tumours, to aid clinicians and pathologists in recognising these entities. This emerging field promises to refine the diagnosis, management, and treatment of thyroid disorders associated with miRNA biogenesis pathway alterations, potentially leading to novel diagnostic and therapeutic approaches.\n                  <\/jats:p>","DOI":"10.1530\/etj-25-0188","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:37:42Z","timestamp":1760708262000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":1,"title":["DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity"],"prefix":"10.1530","volume":"14","author":[{"given":"Lia","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Institute for Research and Innovation in Health of the University of Porto (I3S), Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"},{"name":"RISE-Health, Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal"},{"name":"School of Health Polytechnic of Porto (E2S), Porto, Portugal"}]},{"given":"Rui","family":"Sousa Martins","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health of the University of Porto (I3S), Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"},{"name":"RISE-Health, Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal"}]},{"given":"Valdemar","family":"M\u00e1ximo","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health of the University of Porto (I3S), Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"},{"name":"RISE-Health, Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":true,"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health of the University of Porto (I3S), Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"},{"name":"RISE-Health, Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal"}]},{"given":"Joao","family":"Vinagre","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health of the University of Porto (I3S), Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"},{"name":"RISE-Health, Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal"}]},{"given":"Vania","family":"Nos\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3736-1323","authenticated-orcid":true,"given":"Sule","family":"Canberk","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Endocr Pathol","first-page":"27","article-title":"Overview of the 2022 WHO classification of thyroid neoplasms","volume":"33","author":"Baloch ZW","year":"2022","unstructured":"Baloch ZW\n, \nAsa SL\n, \nBarletta JA\n, et al.\n Overview of the 2022 WHO classification of thyroid neoplasms. Endocr Pathol 2022 33 27\u201363. (https:\/\/doi.org\/10.1007\/s12022-022-09707-3)"},{"key":"bib2","series-title":"Endocr Pathol","first-page":"197","article-title":"Overview of the 2022 WHO classification of familial endocrine tumor syndromes","volume":"33","author":"Nos\u00e9 V","year":"2022","unstructured":"Nos\u00e9 V\n, \nGill A\n, \nTeijeiro JMC\n, et al.\n Overview of the 2022 WHO classification of familial endocrine tumor syndromes. Endocr Pathol 2022 33 197\u2013227. (https:\/\/doi.org\/10.1007\/s12022-022-09705-5)"},{"key":"bib3","series-title":"J Mol Pathol","first-page":"1","article-title":"The multifaceted profile of thyroid disease in the background of DICER1 germline and somatic mutations: then, now and future perspectives","volume":"3","author":"Canberk S","year":"2022","unstructured":"Canberk S\n, \nCorreia M\n, \nLima AR\n, et al.\n The multifaceted profile of thyroid disease in the background of DICER1 germline and somatic mutations: then, now and future perspectives. J Mol Pathol 2022 3 1\u201314. (https:\/\/doi.org\/10.3390\/jmp3010001)"},{"key":"bib4","series-title":"Cancers","first-page":"347","article-title":"Expanding our knowledge of DICER1 gene alterations and their role in thyroid diseases","volume":"16","author":"Riascos MC","year":"2024","unstructured":"Riascos MC\n, \nHuynh A\n, \nFaquin WC\n, et al.\n Expanding our knowledge of DICER1 gene alterations and their role in thyroid diseases. Cancers 2024 16 347. (https:\/\/doi.org\/10.3390\/cancers16020347)"},{"key":"bib5","series-title":"Int J Mol Sci","first-page":"1723","article-title":"Regulatory mechanism of microRNA expression in cancer","volume":"21","author":"Ali Syeda Z","year":"2020","unstructured":"Ali Syeda Z\n, \nLangden SSS\n, \nMunkhzul C\n, et al.\n Regulatory mechanism of microRNA expression in cancer. Int J Mol Sci 2020 21 1723. (https:\/\/doi.org\/10.3390\/ijms21051723)"},{"key":"bib6","series-title":"Int J Mol Med","first-page":"21","article-title":"Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines","volume":"31","author":"Adler D","year":"2013","unstructured":"Adler D\n, \nLindstrot A\n, \nOchsenfahrt J\n, et al.\n Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines. Int J Mol Med 2013 31 21\u201325."},{"key":"bib7","series-title":"Science","first-page":"965","article-title":"DICER1 mutations in familial pleuropulmonary blastoma","volume":"325","author":"Hill DA","year":"2009","unstructured":"Hill DA\n, \nIvanovich J\n, \nPriest JR\n, et al.\n DICER1 mutations in familial pleuropulmonary blastoma. Science 2009 325 965. (https:\/\/doi.org\/10.1126\/science.1174334)"},{"key":"bib8","series-title":"JAMA","first-page":"68","article-title":"DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli\u2013Leydig cell tumors","volume":"305","author":"Rio Frio T","year":"2011","unstructured":"Rio Frio T\n, \nBahubeshi A\n, \nKanellopoulou C\n, et al.\n DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli\u2013Leydig cell tumors. JAMA 2011 305 68\u201377. (https:\/\/doi.org\/10.1001\/jama.2010.1910)"},{"key":"bib9","series-title":"Eur Thyroid J","first-page":"296","article-title":"Analyzing the role of DICER1 germline variations in papillary thyroid carcinoma","volume":"9","author":"Canberk S","year":"2021","unstructured":"Canberk S\n, \nFerreira JC\n, \nPereira L\n, et al.\n Analyzing the role of DICER1 germline variations in papillary thyroid carcinoma. Eur Thyroid J 2021 9 296\u2013303. (https:\/\/doi.org\/10.1159\/000509183)"},{"key":"bib10","series-title":"Clin Endocrinol","first-page":"669","article-title":"Multinodular goitre is a gateway for molecular testing of DICER1 syndrome","volume":"91","author":"Oliver\u2010Petit I","year":"2019","unstructured":"Oliver\u2010Petit I\n, \nBertozzi AI\n, \nGrunenwald S\n, et al.\n Multinodular goitre is a gateway for molecular testing of DICER1 syndrome. Clin Endocrinol 2019 91 669\u2013675. (https:\/\/doi.org\/10.1111\/cen.14074)"},{"key":"bib11","series-title":"J Clin Investig","first-page":"1479","article-title":"DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis","volume":"130","author":"Rivera B","year":"2020","unstructured":"Rivera B\n, \nNadaf J\n, \nFahiminiya S\n, et al.\n DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis. J Clin Investig 2020 130 1479\u20131490. (https:\/\/doi.org\/10.1172\/jci130206)"},{"key":"bib12","series-title":"J Clin Endocrinol Metab","first-page":"3265","article-title":"Whole-genome sequencing of follicular thyroid carcinomas reveal recurrent mutations in MicroRNA processing subunit DGCR8","volume":"106","author":"Paulsson JO","year":"2021","unstructured":"Paulsson JO\n, \nRafati N\n, \nDiLorenzo S\n, et al.\n Whole-genome sequencing of follicular thyroid carcinomas reveal recurrent mutations in MicroRNA processing subunit DGCR8. J Clin Endocrinol Metab 2021 106 3265\u20133282. (https:\/\/doi.org\/10.1210\/clinem\/dgab471)"},{"key":"bib13","series-title":"Int J Mol Sci","first-page":"14812","article-title":"DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions","volume":"23","author":"Rodrigues L","year":"2022","unstructured":"Rodrigues L\n, \nCanberk S\n, \nMacedo S\n, et al.\n DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions. Int J Mol Sci 2022 23 14812. (https:\/\/doi.org\/10.3390\/ijms232314812)"},{"key":"bib14","series-title":"Endocr Pathol","first-page":"25","article-title":"The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasms","volume":"35","author":"Canberk S","year":"2024","unstructured":"Canberk S\n, \nGoncalves J\n, \nRios E\n, et al.\n The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasms. Endocr Pathol 2024 35 25\u201339. (https:\/\/doi.org\/10.1007\/s12022-024-09800-9)"},{"key":"bib15","series-title":"Nat Rev Genet","first-page":"597","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol J","year":"2010","unstructured":"Krol J\n, \nLoedige I\n & \nFilipowicz W\n\n. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010 11 597\u2013610. (https:\/\/doi.org\/10.1038\/nrg2843)"},{"key":"bib16","series-title":"Exp Biol Med","first-page":"395","article-title":"Complexity in regulating microRNA biogenesis in cancer","volume":"245","author":"Chen PS","year":"2020","unstructured":"Chen PS\n, \nLin SC\n & \nTsai SJ\n\n. Complexity in regulating microRNA biogenesis in cancer. Exp Biol Med 2020 245 395\u2013401. (https:\/\/doi.org\/10.1177\/1535370220907314)"},{"key":"bib17","series-title":"Methods Mol Biol","first-page":"3","article-title":"MicroRNA biogenesis and cancer","volume":"676","author":"Winter J","year":"2011","unstructured":"Winter J\n & \nDiederichs S\n\n. MicroRNA biogenesis and cancer. Methods Mol Biol 2011 676 3\u201322. (https:\/\/doi.org\/10.1007\/978-1-60761-863-8_1)"},{"key":"bib18","series-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub","first-page":"205","article-title":"MicroRNA biogenesis, functionality and cancer relevance","volume":"150","author":"Kusenda B","year":"2006","unstructured":"Kusenda B\n, \nMraz M\n, \nMayer J\n, et al.\n MicroRNA biogenesis, functionality and cancer relevance. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2006 150 205\u2013215. (https:\/\/doi.org\/10.5507\/bp.2006.029)"},{"key":"bib19","series-title":"Nature","first-page":"834","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu J","year":"2005","unstructured":"Lu J\n, \nGetz G\n, \nMiska EA\n, et al.\n MicroRNA expression profiles classify human cancers. Nature 2005 435 834\u2013838. (https:\/\/doi.org\/10.1038\/nature03702)"},{"key":"bib20","series-title":"Proc Natl Acad Sci U S A","first-page":"2257","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia S","year":"2006","unstructured":"Volinia S\n, \nCalin GA\n, \nLiu CG\n, et al.\n A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006 103 2257\u20132261. (https:\/\/doi.org\/10.1073\/pnas.0510565103)"},{"key":"bib21","series-title":"Cell","first-page":"112","article-title":"Phosphorylation of the human microRNA-generating complex mediates MAPK\/Erk signaling","volume":"139","author":"Paroo Z","year":"2009","unstructured":"Paroo Z\n, \nYe X\n, \nChen S\n, et al.\n Phosphorylation of the human microRNA-generating complex mediates MAPK\/Erk signaling. Cell 2009 139 112\u2013122. (https:\/\/doi.org\/10.1016\/j.cell.2009.06.044)"},{"key":"bib22","series-title":"Cancer Cell","first-page":"723","article-title":"ERK activation globally downregulates miRNAs through phosphorylating exportin-5","volume":"30","author":"Sun HL","year":"2016","unstructured":"Sun HL\n, \nCui R\n, \nZhou J\n, et al.\n ERK activation globally downregulates miRNAs through phosphorylating exportin-5. Cancer Cell 2016 30 723\u2013736. (https:\/\/doi.org\/10.1016\/j.ccell.2016.10.001)"},{"key":"bib23","series-title":"Surgery","first-page":"155","article-title":"Thyroid nodule molecular profiling: the clinical utility of Afirma Xpression Atlas for nodules with Afirma Genomic Sequencing Classifier-suspicious results","volume":"171","author":"Babazadeh NT","year":"2022","unstructured":"Babazadeh NT\n, \nSinclair TJ\n, \nKrishnamurthy V\n, et al.\n Thyroid nodule molecular profiling: the clinical utility of Afirma Xpression Atlas for nodules with Afirma Genomic Sequencing Classifier-suspicious results. Surgery 2022 171 155\u2013159. (https:\/\/doi.org\/10.1016\/j.surg.2021.08.058)"},{"key":"bib24","series-title":"J Clin Endocrinol Metab","first-page":"1600","article-title":"MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility","volume":"93","author":"Nikiforova MN","year":"2008","unstructured":"Nikiforova MN\n, \nTseng GC\n, \nSteward D\n, et al.\n MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. J Clin Endocrinol Metab 2008 93 1600\u20131608. (https:\/\/doi.org\/10.1210\/jc.2007-2696)"},{"key":"bib25","series-title":"Biophys Rev","first-page":"1081","article-title":"DICER: structure, function, and regulation","volume":"13","author":"Vergani-Junior CA","year":"2021","unstructured":"Vergani-Junior CA\n, \nTonon-da-Silva G\n, \nInan MD\n, et al.\n DICER: structure, function, and regulation. Biophys Rev 2021 13 1081\u20131090. (https:\/\/doi.org\/10.1007\/s12551-021-00902-w)"},{"key":"bib26","series-title":"Virchows Arch","first-page":"105","article-title":"Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study","volume":"485","author":"Condello V","year":"2024","unstructured":"Condello V\n, \nRoberts JW\n, \nStenman A\n, et al.\n Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study. Virchows Arch 2024 485 105\u2013114. (https:\/\/doi.org\/10.1007\/s00428-024-03802-y)"},{"key":"bib27","series-title":"Int J Cancer","first-page":"2030","article-title":"The prevalence of DICER1 pathogenic variation in population databases","volume":"141","author":"Kim J","year":"2017","unstructured":"Kim J\n, \nField A\n, \nSchultz KAP\n, et al.\n The prevalence of DICER1 pathogenic variation in population databases. Int J Cancer 2017 141 2030\u20132036. (https:\/\/doi.org\/10.1002\/ijc.30907)"},{"key":"bib28","series-title":"Hum Mutat","first-page":"1939","article-title":"Ten years of DICER1 mutations: provenance, distribution, and associated phenotypes","volume":"40","author":"de Kock L","year":"2019","unstructured":"de Kock L\n, \nWu MK\n & \nFoulkes WD\n\n. Ten years of DICER1 mutations: provenance, distribution, and associated phenotypes. Hum Mutat 2019 40 1939\u20131953. (https:\/\/doi.org\/10.1002\/humu.23877)"},{"key":"bib29","series-title":"Oncogene","first-page":"5486","article-title":"Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness","volume":"38","author":"Ram\u00edrez-Moya J","year":"2019","unstructured":"Ram\u00edrez-Moya J\n, \nWert-Lamas L\n, \nRiesco-Eizaguirre G\n, et al.\n Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness. Oncogene 2019 38 5486\u20135499. (https:\/\/doi.org\/10.1038\/s41388-019-0804-8)"},{"key":"bib30","series-title":"J Med Genet","first-page":"141","article-title":"A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1","volume":"59","author":"Pont\u00e9n E","year":"2022","unstructured":"Pont\u00e9n E\n, \nFrisk S\n, \nTaylan F\n, et al.\n A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1. J Med Genet 2022 59 141\u2013146. (https:\/\/doi.org\/10.1136\/jmedgenet-2020-107385)"},{"key":"bib31","series-title":"Nature","first-page":"331","article-title":"Structure of the human DICER-pre-miRNA complex in a dicing state","volume":"615","author":"Lee YY","year":"2023","unstructured":"Lee YY\n, \nLee H\n, \nKim H\n, et al.\n Structure of the human DICER-pre-miRNA complex in a dicing state. Nature 2023 615 331\u2013338. (https:\/\/doi.org\/10.1038\/s41586-023-05723-3)"},{"key":"bib32","series-title":"F1000Res","first-page":"214","article-title":"Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma\/DICER1 syndrome: a unique variant of the two-hit tumor suppression model","volume":"4","author":"Brenneman M","year":"2015","unstructured":"Brenneman M\n, \nField A\n, \nYang J\n, et al.\n Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma\/DICER1 syndrome: a unique variant of the two-hit tumor suppression model. F1000Res 2015 4 214. (https:\/\/doi.org\/10.12688\/f1000research.6746.2)"},{"key":"bib33","series-title":"Surg Pathol Clin","first-page":"107","article-title":"On the chopping block: overview of DICER1 mutations in endocrine and neuroendocrine neoplasms","volume":"16","author":"Juhlin CC","year":"2023","unstructured":"Juhlin CC\n\n. On the chopping block: overview of DICER1 mutations in endocrine and neuroendocrine neoplasms. Surg Pathol Clin 2023 16 107\u2013118. (https:\/\/doi.org\/10.1016\/j.path.2022.09.010)"},{"key":"bib34","series-title":"J Clin Endocrinol Metab","first-page":"1614","article-title":"Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study","volume":"102","author":"Khan NE","year":"2017","unstructured":"Khan NE\n, \nBauer AJ\n, \nSchultz KAP\n, et al.\n Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study. J Clin Endocrinol Metab 2017 102 1614\u20131622. (https:\/\/doi.org\/10.1210\/jc.2016-2954)"},{"key":"bib35","series-title":"Genes Dev","first-page":"2700","article-title":"Dicer1 functions as a haploinsufficient tumor suppressor","volume":"23","author":"Kumar MS","year":"2009","unstructured":"Kumar MS\n, \nPester RE\n, \nChen CY\n, et al.\n Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev 2009 23 2700\u20132704. (https:\/\/doi.org\/10.1101\/gad.1848209)"},{"key":"bib36","series-title":"Am J Clin Pathol","first-page":"379","article-title":"Multinodular goiter progression toward malignancy in a case of DICER1 syndrome: histologic and molecular alterations","volume":"149","author":"Gullo I","year":"2018","unstructured":"Gullo I\n, \nBatista R\n, \nRodrigues-Pereira P\n, et al.\n Multinodular goiter progression toward malignancy in a case of DICER1 syndrome: histologic and molecular alterations. Am J Clin Pathol 2018 149 379\u2013386. (https:\/\/doi.org\/10.1093\/ajcp\/aqy004)"},{"key":"bib37","series-title":"J Clin Endocrinol Metab","first-page":"3637","article-title":"Deep sequencing reveals spatially distributed distinct hot spot mutations in DICER1-related multinodular goiter","volume":"101","author":"de Kock L","year":"2016","unstructured":"de Kock L\n, \nBah I\n, \nRevil T\n, et al.\n Deep sequencing reveals spatially distributed distinct hot spot mutations in DICER1-related multinodular goiter. J Clin Endocrinol Metab 2016 101 3637\u20133645. (https:\/\/doi.org\/10.1210\/jc.2016-1328)"},{"key":"bib38","series-title":"Genet Med Open","article-title":"A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance and cancer, thyroid, and other phenotypes in 2 population-scale cohorts","volume":"2","author":"Kim J","year":"2024","unstructured":"Kim J\n, \nHaley J\n, \nHatton JN\n, et al.\n A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance and cancer, thyroid, and other phenotypes in 2 population-scale cohorts. Genet Med Open 2024 2 101846. (https:\/\/doi.org\/10.1016\/j.gimo.2024.101846)"},{"key":"bib39","series-title":"Endocr Pathol","first-page":"437","article-title":"DICER1 mutations occur in more than one-third of follicular-patterned pediatric papillary thyroid carcinomas and correlate with a low-risk disease and female gender predilection","volume":"33","author":"Onder S","year":"2022","unstructured":"Onder S\n, \nMete O\n, \nYilmaz I\n, et al.\n DICER1 mutations occur in more than one-third of follicular-patterned pediatric papillary thyroid carcinomas and correlate with a low-risk disease and female gender predilection. Endocr Pathol 2022 33 437\u2013445. (https:\/\/doi.org\/10.1007\/s12022-022-09736-y)"},{"key":"bib40","series-title":"JAMA Oncol","first-page":"1323","article-title":"Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children","volume":"8","author":"Gallant JN","year":"2022","unstructured":"Gallant JN\n, \nChen SC\n, \nOrtega CA\n, et al.\n Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children. JAMA Oncol 2022 8 1323\u20131327. (https:\/\/doi.org\/10.1001\/jamaoncol.2022.1655)"},{"key":"bib41","series-title":"J Clin Endocrinol Metab","first-page":"2009","article-title":"DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma","volume":"103","author":"Wasserman JD","year":"2018","unstructured":"Wasserman JD\n, \nSabbaghian N\n, \nFahiminiya S\n, et al.\n DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma. J Clin Endocrinol Metab 2018 103 2009\u20132015. (https:\/\/doi.org\/10.1210\/jc.2017-02698)"},{"key":"bib42","series-title":"Endocr Pathol","first-page":"336","article-title":"High prevalence of DICER1 mutations and low frequency of gene fusions in pediatric follicular-patterned tumors of the thyroid","volume":"32","author":"Bae JS","year":"2021","unstructured":"Bae JS\n, \nJung SH\n, \nHirokawa M\n, et al.\n High prevalence of DICER1 mutations and low frequency of gene fusions in pediatric follicular-patterned tumors of the thyroid. Endocr Pathol 2021 32 336\u2013346. (https:\/\/doi.org\/10.1007\/s12022-021-09688-9)"},{"key":"bib43","series-title":"Mod Pathol","first-page":"1264","article-title":"Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations","volume":"33","author":"Chernock RD","year":"2020","unstructured":"Chernock RD\n, \nRivera B\n, \nBorrelli N\n, et al.\n Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations. Mod Pathol 2020 33 1264\u20131274. (https:\/\/doi.org\/10.1038\/s41379-020-0458-7)"},{"key":"bib44","series-title":"Endocr Pathol","first-page":"279","article-title":"DICER1 mutations do not always indicate dismal prognosis in pediatric poorly differentiated thyroid carcinomas","volume":"34","author":"Yegen G","year":"2023","unstructured":"Yegen G\n, \nAltay AY\n, \nY\u0131lmaz \u0130\n, et al.\n DICER1 mutations do not always indicate dismal prognosis in pediatric poorly differentiated thyroid carcinomas. Endocr Pathol 2023 34 279\u2013286. (https:\/\/doi.org\/10.1007\/s12022-023-09780-2)"},{"key":"bib45","series-title":"Am J Surg Pathol","first-page":"1277","article-title":"DICER1 mutations define the landscape of poorly differentiated thyroid carcinoma in children and young adults: case report and literature review","volume":"48","author":"Ver Berne J","year":"2024","unstructured":"Ver Berne J\n, \nVan den Bruel A\n, \nVermeire S\n, et al.\n DICER1 mutations define the landscape of poorly differentiated thyroid carcinoma in children and young adults: case report and literature review. Am J Surg Pathol 2024 48 1277\u20131283. (https:\/\/doi.org\/10.1097\/pas.0000000000002265)"},{"key":"bib46","series-title":"Virchows Arch","first-page":"787","article-title":"Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term \u201cthyroblastoma\u201d more appropriate?","volume":"477","author":"Agaimy A","year":"2020","unstructured":"Agaimy A\n, \nWitkowski L\n, \nStoehr R\n, et al.\n Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term \u201cthyroblastoma\u201d more appropriate? Virchows Arch 2020 477 787\u2013798. (https:\/\/doi.org\/10.1007\/s00428-020-02853-1)"},{"key":"bib47","series-title":"Am J Surg Pathol","first-page":"826","article-title":"Recurrent DICER1 hotspot mutations in malignant thyroid gland teratomas: molecular characterization and proposal for a separate classification","volume":"44","author":"Rooper LM","year":"2020","unstructured":"Rooper LM\n, \nBynum JP\n, \nMiller KP\n, et al.\n Recurrent DICER1 hotspot mutations in malignant thyroid gland teratomas: molecular characterization and proposal for a separate classification. Am J Surg Pathol 2020 44 826\u2013833. (https:\/\/doi.org\/10.1097\/pas.0000000000001430)"},{"key":"bib48","series-title":"Adv Anat Pathol","first-page":"136","article-title":"From malignant thyroid teratoma to thyroblastoma: evolution of a newly-recognized DICER1 -associated malignancy","volume":"30","author":"Rooper LM","year":"2023","unstructured":"Rooper LM\n\n. From malignant thyroid teratoma to thyroblastoma: evolution of a newly-recognized DICER1 -associated malignancy. Adv Anat Pathol 2023 30 136\u2013145. (https:\/\/doi.org\/10.1097\/pap.0000000000000364)"},{"key":"bib49","series-title":"Endocr Relat Cancer","first-page":"295","article-title":"GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours","volume":"27","author":"Paulsson JO","year":"2020","unstructured":"Paulsson JO\n, \nWang N\n, \nGao J\n, et al.\n GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours. Endocr Relat Cancer 2020 27 295\u2013308. (https:\/\/doi.org\/10.1530\/erc-19-0446)"},{"key":"bib50","series-title":"Virchows Arch","first-page":"293","article-title":"Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform","volume":"480","author":"Ghossein CA","year":"2022","unstructured":"Ghossein CA\n, \nDogan S\n, \nFarhat N\n, et al.\n Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform. Virchows Arch 2022 480 293\u2013302. (https:\/\/doi.org\/10.1007\/s00428-021-03212-4)"},{"key":"bib51","series-title":"Clin Cancer Res","first-page":"234","article-title":"Update on pediatric surveillance recommendations for PTEN hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex","volume":"31","author":"Schultz KAP","year":"2025","unstructured":"Schultz KAP\n, \nMacFarland SP\n, \nPerrino MR\n, et al.\n Update on pediatric surveillance recommendations for PTEN hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex. Clin Cancer Res 2025 31 234\u2013244. (https:\/\/doi.org\/10.1158\/1078-0432.ccr-24-1947)"},{"key":"bib52","series-title":"Thyroid","first-page":"1120","article-title":"Predominant DICER1 pathogenic variants in pediatric follicular thyroid carcinomas","volume":"30","author":"Lee YA","year":"2020","unstructured":"Lee YA\n, \nIm SW\n, \nJung KC\n, et al.\n Predominant DICER1 pathogenic variants in pediatric follicular thyroid carcinomas. Thyroid 2020 30 1120\u20131131. (https:\/\/doi.org\/10.1089\/thy.2019.0233)"},{"key":"bib53","series-title":"Thyroid","first-page":"1225","article-title":"DICER1 variants in pediatric and young adult thyroid nodules","volume":"34","author":"Mastnikova K","year":"2024","unstructured":"Mastnikova K\n, \nBulanova Pekova B\n, \nKuklikova V\n, et al.\n DICER1 variants in pediatric and young adult thyroid nodules. Thyroid 2024 34 1225\u20131233. (https:\/\/doi.org\/10.1089\/thy.2024.0188)"},{"key":"bib54","series-title":"J Clin Endocrinol Metab","first-page":"1","article-title":"DICER1 mutations and differentiated thyroid carcinoma: evidence of a direct association","volume":"101","author":"Rutter MM","year":"2016","unstructured":"Rutter MM\n, \nJha P\n, \nSchultz KA\n, et al.\n DICER1 mutations and differentiated thyroid carcinoma: evidence of a direct association. J Clin Endocrinol Metab 2016 101 1\u20135. (https:\/\/doi.org\/10.1210\/jc.2015-2169)"},{"key":"bib55","series-title":"Endocr Connect","article-title":"Clinical, molecular and radiological characteristics of thyroid nodules with somatic DICER1 mutations in adults","volume":"14","author":"Han Y","year":"2025","unstructured":"Han Y\n, \nLi S\n, \nZhao B\n, et al.\n Clinical, molecular and radiological characteristics of thyroid nodules with somatic DICER1 mutations in adults. Endocr Connect 2025 14 e250125. (https:\/\/doi.org\/10.1530\/ec-25-0125)"},{"key":"bib56","series-title":"Front Endocrinol","article-title":"DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer","volume":"14","author":"Ricarte-Filho JC","year":"2023","unstructured":"Ricarte-Filho JC\n, \nCasado-Medrano V\n, \nReichenberger E\n, et al.\n DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer. Front Endocrinol 2023 14 1083382. (https:\/\/doi.org\/10.3389\/fendo.2023.1083382)"},{"key":"bib57","series-title":"Int J Mol Sci","first-page":"909","article-title":"The role of miRNA in papillary thyroid cancer in the context of miRNA Let-7 family","volume":"17","author":"Perdas E","year":"2016","unstructured":"Perdas E\n, \nStawski R\n, \nNowak D\n, et al.\n The role of miRNA in papillary thyroid cancer in the context of miRNA Let-7 family. Int J Mol Sci 2016 17 909. (https:\/\/doi.org\/10.3390\/ijms17060909)"},{"key":"bib58","series-title":"Cells","first-page":"561","article-title":"Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma","volume":"13","author":"Rodrigues L","year":"2024","unstructured":"Rodrigues L\n, \nDa Cruz Paula A\n, \nSoares P\n, et al.\n Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma. Cells 2024 13 561. (https:\/\/doi.org\/10.3390\/cells13070561)"},{"key":"bib59","series-title":"Int J Genomics","first-page":"5789769","article-title":"Racial differences in expression levels of miRNA machinery-related genes, dicer, drosha, DGCR8, and AGO2, in Asian Korean papillary thyroid carcinoma and comparative validation using the cancer genome atlas","volume":"2017","author":"Kim J","year":"2017","unstructured":"Kim J\n, \nPark WJ\n, \nJeong KJ\n, et al.\n Racial differences in expression levels of miRNA machinery-related genes, dicer, drosha, DGCR8, and AGO2, in Asian Korean papillary thyroid carcinoma and comparative validation using the cancer genome atlas. Int J Genomics 2017 2017 5789769. (https:\/\/doi.org\/10.1155\/2017\/5789769)"},{"key":"bib60","series-title":"JAMA Netw Open","article-title":"A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance, and phenotype","volume":"4","author":"Mirshahi UL","year":"2021","unstructured":"Mirshahi UL\n, \nKim J\n, \nBest AF\n, et al.\n A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance, and phenotype. JAMA Netw Open 2021 4 e210112. (https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.0112)"},{"key":"bib61","series-title":"Gynecol Endocrinol","first-page":"617","article-title":"Virilising Sertoli\u2013Leydig cell tumour associated with thyroid papillary carcinoma: case report and general considerations","volume":"26","author":"Poiana C","year":"2010","unstructured":"Poiana C\n, \nVirtej I\n, \nCarsote M\n, et al.\n Virilising Sertoli\u2013Leydig cell tumour associated with thyroid papillary carcinoma: case report and general considerations. Gynecol Endocrinol 2010 26 617\u2013622. (https:\/\/doi.org\/10.3109\/09513591003686361)"},{"key":"bib62","series-title":"Cancer","first-page":"198","article-title":"Comparison of the clinicopathologic features and prognosis of bilateral versus unilateral multifocal papillary thyroid cancer: an updated study with more than 2000 consecutive patients","volume":"122","author":"Wang W","year":"2016","unstructured":"Wang W\n, \nSu X\n, \nHe K\n, et al.\n Comparison of the clinicopathologic features and prognosis of bilateral versus unilateral multifocal papillary thyroid cancer: an updated study with more than 2000 consecutive patients. Cancer 2016 122 198\u2013206. (https:\/\/doi.org\/10.1002\/cncr.29689)"},{"key":"bib63","series-title":"Langenbecks Arch Surg","first-page":"155","article-title":"Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES)","volume":"399","author":"Sancho JJ","year":"2014","unstructured":"Sancho JJ\n, \nLennard TW\n, \nPaunovic I\n, et al.\n Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES). Langenbecks Arch Surg 2014 399 155\u2013163. (https:\/\/doi.org\/10.1007\/s00423-013-1152-8)"},{"key":"bib64","series-title":"J Mol Pathol","first-page":"264","article-title":"DICER1 tumor syndrome: a retrospective review and future perspectives","volume":"5","author":"Cazzato G","year":"2024","unstructured":"Cazzato G\n, \nCasatta N\n, \nLupo C\n, et al.\n DICER1 tumor syndrome: a retrospective review and future perspectives. J Mol Pathol 2024 5 264\u2013275. (https:\/\/doi.org\/10.3390\/jmp5030019)"},{"key":"bib65","series-title":"Fam Cancer","first-page":"337","article-title":"Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group","volume":"20","author":"Bakhuizen JJ","year":"2021","unstructured":"Bakhuizen JJ\n, \nHanson H\n, \nvan der Tuin K\n, et al.\n Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group. Fam Cancer 2021 20 337\u2013348. (https:\/\/doi.org\/10.1007\/s10689-021-00264-y)"},{"key":"bib66","series-title":"Thyroid","first-page":"547","article-title":"Follicular thyroid carcinoma arising after hematopoietic stem cell transplantation in a child with pleuropulmonary blastoma","volume":"22","author":"Shin SH","year":"2012","unstructured":"Shin SH\n, \nYoon JH\n, \nSon MH\n, et al.\n Follicular thyroid carcinoma arising after hematopoietic stem cell transplantation in a child with pleuropulmonary blastoma. Thyroid 2012 22 547\u2013551. (https:\/\/doi.org\/10.1089\/thy.2011.0161)"},{"key":"bib67","series-title":"Clin Cancer Res","first-page":"5681","article-title":"DICER1-Related tumor predisposition: identification of at-risk individuals and recommended surveillance strategies","volume":"30","author":"Schultz KAP","year":"2024","unstructured":"Schultz KAP\n, \nNelson AT\n, \nMallinger PHR\n, et al.\n DICER1-Related tumor predisposition: identification of at-risk individuals and recommended surveillance strategies. Clin Cancer Res 2024 30 5681\u20135692. (https:\/\/doi.org\/10.1158\/1078-0432.ccr-24-1532)"},{"key":"bib68","series-title":"Eur J Endocrinol","first-page":"321","article-title":"Familial vs sporadic papillary thyroid carcinoma: a matched-case comparative study showing similar clinical\/prognostic behaviour","volume":"170","author":"Pinto AE","year":"2014","unstructured":"Pinto AE\n, \nSilva GL\n, \nHenrique R\n, et al.\n Familial vs sporadic papillary thyroid carcinoma: a matched-case comparative study showing similar clinical\/prognostic behaviour. Eur J Endocrinol 2014 170 321\u2013327. (https:\/\/doi.org\/10.1530\/eje-13-0865)"},{"key":"bib69","series-title":"Diagn Histopathol","first-page":"154","article-title":"Oncocytic thyroid neoplasms: from histology to molecular biology","volume":"25","author":"Canberk S","year":"2019","unstructured":"Canberk S\n, \nLima AR\n, \nCorreia M\n, et al.\n Oncocytic thyroid neoplasms: from histology to molecular biology. Diagn Histopathol 2019 25 154\u2013165. (https:\/\/doi.org\/10.1016\/j.mpdhp.2019.02.002)"},{"key":"bib70","series-title":"Development","first-page":"1895","article-title":"Tet family proteins and 5-hydroxymethylcytosine in development and disease","volume":"139","author":"Tan L","year":"2012","unstructured":"Tan L\n & \nShi YG\n\n. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development 2012 139 1895\u20131902. (https:\/\/doi.org\/10.1242\/dev.070771)"},{"key":"bib71","series-title":"Clin Epigenetics","first-page":"176","article-title":"DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker","volume":"13","author":"Azizgolshani N","year":"2021","unstructured":"Azizgolshani N\n, \nPetersen CL\n, \nChen Y\n, et al.\n DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker. Clin Epigenetics 2021 13 176. (https:\/\/doi.org\/10.1186\/s13148-021-01156-9)"},{"key":"bib72","series-title":"Endocr Pathol","first-page":"359","article-title":"Loss of 5-Hydroxymethylcytosine is an epigenetic hallmark of thyroid carcinomas with TERT promoter mutations","volume":"31","author":"Oishi N","year":"2020","unstructured":"Oishi N\n, \nVuong HG\n, \nMochizuki K\n, et al.\n Loss of 5-Hydroxymethylcytosine is an epigenetic hallmark of thyroid carcinomas with TERT promoter mutations. Endocr Pathol 2020 31 359\u2013366. (https:\/\/doi.org\/10.1007\/s12022-020-09652-z)"},{"key":"bib73","series-title":"Nat Rev Mol Cell Biol","first-page":"417","article-title":"Swiss army knives: non-canonical functions of nuclear Drosha and Dicer","volume":"16","author":"Burger K","year":"2015","unstructured":"Burger K\n & \nGullerova M\n\n. Swiss army knives: non-canonical functions of nuclear Drosha and Dicer. Nat Rev Mol Cell Biol 2015 16 417\u2013430. (https:\/\/doi.org\/10.1038\/nrm3994)"},{"key":"bib74","series-title":"Nat Struct Mol Biol","first-page":"998","article-title":"Argonaute proteins couple chromatin silencing to alternative splicing","volume":"19","author":"Ameyar-Zazoua M","year":"2012","unstructured":"Ameyar-Zazoua M\n, \nRachez C\n, \nSouidi M\n, et al.\n Argonaute proteins couple chromatin silencing to alternative splicing. Nat Struct Mol Biol 2012 19 998\u20131004. (https:\/\/doi.org\/10.1038\/nsmb.2373)"},{"key":"bib75","series-title":"Mol Cell Biol","first-page":"9724","article-title":"Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster","volume":"25","author":"Haussecker D","year":"2005","unstructured":"Haussecker D\n & \nProudfoot NJ\n\n. Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster. Mol Cell Biol 2005 25 9724\u20139733. (https:\/\/doi.org\/10.1128\/mcb.25.21.9724-9733.2005)"},{"key":"bib76","series-title":"Front Endocrinol","article-title":"Epigenomics in hurthle cell neoplasms: filling in the gaps towards clinical application","volume":"12","author":"Canberk S","year":"2021","unstructured":"Canberk S\n, \nLima AR\n, \nPinto M\n, et al.\n Epigenomics in hurthle cell neoplasms: filling in the gaps towards clinical application. Front Endocrinol 2021 12 674666. (https:\/\/doi.org\/10.3389\/fendo.2021.674666)"},{"key":"bib77","series-title":"Hum Pathol","first-page":"9","article-title":"Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors","volume":"81","author":"Jung CK","year":"2018","unstructured":"Jung CK\n, \nKim Y\n, \nJeon S\n, et al.\n Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors. Hum Pathol 2018 81 9\u201317. (https:\/\/doi.org\/10.1016\/j.humpath.2018.04.018)"},{"key":"bib78","series-title":"Epigenetics","first-page":"105","article-title":"The epigenetic regulation of dicer and microRNA biogenesis by panobinostat","volume":"12","author":"Hoffend NC","year":"2017","unstructured":"Hoffend NC\n, \nMagner WJ\n & \nTomasi TB\n\n. The epigenetic regulation of dicer and microRNA biogenesis by panobinostat. Epigenetics 2017 12 105\u2013112. (https:\/\/doi.org\/10.1080\/15592294.2016.1267886)"},{"key":"bib79","series-title":"Biochim Biophys Acta Bioenerg","first-page":"591","article-title":"Molecular and metabolic features of oncocytomas: seeking the blueprints of indolent cancers","volume":"1858","author":"De Luise M","year":"2017","unstructured":"De Luise M\n, \nGirolimetti G\n, \nOkere B\n, et al.\n Molecular and metabolic features of oncocytomas: seeking the blueprints of indolent cancers. Biochim Biophys Acta Bioenerg 2017 1858 591\u2013601. (https:\/\/doi.org\/10.1016\/j.bbabio.2017.01.009)"},{"key":"bib80","series-title":"J Clin Investig","first-page":"625","article-title":"HIF-1\u03b1 promotes autophagic proteolysis of dicer and enhances tumor metastasis","volume":"128","author":"Lai HH","year":"2018","unstructured":"Lai HH\n, \nLi JN\n, \nWang MY\n, et al.\n HIF-1\u03b1 promotes autophagic proteolysis of dicer and enhances tumor metastasis. J Clin Investig 2018 128 625\u2013643. (https:\/\/doi.org\/10.1172\/jci89212)"},{"key":"bib81","series-title":"Cancer Res","first-page":"2570","article-title":"A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells","volume":"68","author":"Ting AH","year":"2008","unstructured":"Ting AH\n, \nSuzuki H\n, \nCope L\n, et al.\n A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Res 2008 68 2570\u20132575. (https:\/\/doi.org\/10.1158\/0008-5472.can-07-6405)"},{"key":"bib82","series-title":"Nat Commun","first-page":"5203","article-title":"Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER","volume":"5","author":"van den Beucken T","year":"2014","unstructured":"van den Beucken T\n, \nKoch E\n, \nChu K\n, et al.\n Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun 2014 5 5203. (https:\/\/doi.org\/10.1038\/ncomms6203)"},{"key":"bib83","series-title":"Virchows Arch","first-page":"755","article-title":"Histological clues of DICER1 mutations in thyroid nodules","volume":"485","author":"Jung CK","year":"2024","unstructured":"Jung CK\n, \nLiu Z\n, \nHirokawa M\n, et al.\n Histological clues of DICER1 mutations in thyroid nodules. Virchows Arch 2024 485 755\u2013757. (https:\/\/doi.org\/10.1007\/s00428-024-03915-4)"},{"key":"bib84","series-title":"J Clin Oncol","first-page":"668","article-title":"Neoplasm risk among individuals with a pathogenic germline variant in DICER1","volume":"37","author":"Stewart DR","year":"2019","unstructured":"Stewart DR\n, \nBest AF\n, \nWilliams GM\n, et al.\n Neoplasm risk among individuals with a pathogenic germline variant in DICER1. J Clin Oncol 2019 37 668\u2013676. (https:\/\/doi.org\/10.1200\/jco.2018.78.4678)"},{"key":"bib85","series-title":"Cancer Cytopathol","first-page":"746","article-title":"Cytomorphologic features of thyroid disease in patients with DICER1 mutations: a report of cytology-histopathology correlation in 7 patients","volume":"128","author":"Darbinyan A","year":"2020","unstructured":"Darbinyan A\n, \nMorotti R\n, \nCai G\n, et al.\n Cytomorphologic features of thyroid disease in patients with DICER1 mutations: a report of cytology-histopathology correlation in 7 patients. Cancer Cytopathol 2020 128 746\u2013756. (https:\/\/doi.org\/10.1002\/cncy.22329)"},{"key":"bib86","series-title":"Pediatr Blood Cancer","article-title":"Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): a report from the International Pleuropulmonary Blastoma\/DICER1 registry","volume":"71","author":"Schoettler PJ","year":"2024","unstructured":"Schoettler PJ\n, \nSmith CC\n, \nNishitani M\n, et al.\n Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): a report from the International Pleuropulmonary Blastoma\/DICER1 registry. Pediatr Blood Cancer 2024 71 e31090. (https:\/\/doi.org\/10.1002\/pbc.31090)"},{"key":"bib87","series-title":"AJNR Am J Neuroradiol","first-page":"626","article-title":"Imaging features of primary intracranial sarcoma with DICER1 mutation: a multicenter case series","volume":"45","author":"Eldaya RW","year":"2024","unstructured":"Eldaya RW\n, \nFagan RJ\n, \nDagher SA\n, et al.\n Imaging features of primary intracranial sarcoma with DICER1 mutation: a multicenter case series. AJNR Am J Neuroradiol 2024 45 626\u2013631. (https:\/\/doi.org\/10.3174\/ajnr.a8192)"},{"key":"bib1","series-title":"Endocr Pathol","first-page":"27","article-title":"Overview of the 2022 WHO classification of thyroid neoplasms","volume":"33","author":"Baloch ZW","year":"2022","unstructured":"Baloch ZW\n, \nAsa SL\n, \nBarletta JA\n, et al.\n Overview of the 2022 WHO classification of thyroid neoplasms. Endocr Pathol 2022 33 27\u201363. (https:\/\/doi.org\/10.1007\/s12022-022-09707-3)"},{"key":"bib2","series-title":"Endocr Pathol","first-page":"197","article-title":"Overview of the 2022 WHO classification of familial endocrine tumor syndromes","volume":"33","author":"Nos\u00e9 V","year":"2022","unstructured":"Nos\u00e9 V\n, \nGill A\n, \nTeijeiro JMC\n, et al.\n Overview of the 2022 WHO classification of familial endocrine tumor syndromes. Endocr Pathol 2022 33 197\u2013227. (https:\/\/doi.org\/10.1007\/s12022-022-09705-5)"},{"key":"bib3","series-title":"J Mol Pathol","first-page":"1","article-title":"The multifaceted profile of thyroid disease in the background of DICER1 germline and somatic mutations: then, now and future perspectives","volume":"3","author":"Canberk S","year":"2022","unstructured":"Canberk S\n, \nCorreia M\n, \nLima AR\n, et al.\n The multifaceted profile of thyroid disease in the background of DICER1 germline and somatic mutations: then, now and future perspectives. J Mol Pathol 2022 3 1\u201314. (https:\/\/doi.org\/10.3390\/jmp3010001)"},{"key":"bib4","series-title":"Cancers","first-page":"347","article-title":"Expanding our knowledge of DICER1 gene alterations and their role in thyroid diseases","volume":"16","author":"Riascos MC","year":"2024","unstructured":"Riascos MC\n, \nHuynh A\n, \nFaquin WC\n, et al.\n Expanding our knowledge of DICER1 gene alterations and their role in thyroid diseases. Cancers 2024 16 347. (https:\/\/doi.org\/10.3390\/cancers16020347)"},{"key":"bib5","series-title":"Int J Mol Sci","first-page":"1723","article-title":"Regulatory mechanism of microRNA expression in cancer","volume":"21","author":"Ali Syeda Z","year":"2020","unstructured":"Ali Syeda Z\n, \nLangden SSS\n, \nMunkhzul C\n, et al.\n Regulatory mechanism of microRNA expression in cancer. Int J Mol Sci 2020 21 1723. (https:\/\/doi.org\/10.3390\/ijms21051723)"},{"key":"bib6","series-title":"Int J Mol Med","first-page":"21","article-title":"Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines","volume":"31","author":"Adler D","year":"2013","unstructured":"Adler D\n, \nLindstrot A\n, \nOchsenfahrt J\n, et al.\n Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines. Int J Mol Med 2013 31 21\u201325."},{"key":"bib7","series-title":"Science","first-page":"965","article-title":"DICER1 mutations in familial pleuropulmonary blastoma","volume":"325","author":"Hill DA","year":"2009","unstructured":"Hill DA\n, \nIvanovich J\n, \nPriest JR\n, et al.\n DICER1 mutations in familial pleuropulmonary blastoma. Science 2009 325 965. (https:\/\/doi.org\/10.1126\/science.1174334)"},{"key":"bib8","series-title":"JAMA","first-page":"68","article-title":"DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli\u2013Leydig cell tumors","volume":"305","author":"Rio Frio T","year":"2011","unstructured":"Rio Frio T\n, \nBahubeshi A\n, \nKanellopoulou C\n, et al.\n DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli\u2013Leydig cell tumors. JAMA 2011 305 68\u201377. (https:\/\/doi.org\/10.1001\/jama.2010.1910)"},{"key":"bib9","series-title":"Eur Thyroid J","first-page":"296","article-title":"Analyzing the role of DICER1 germline variations in papillary thyroid carcinoma","volume":"9","author":"Canberk S","year":"2021","unstructured":"Canberk S\n, \nFerreira JC\n, \nPereira L\n, et al.\n Analyzing the role of DICER1 germline variations in papillary thyroid carcinoma. Eur Thyroid J 2021 9 296\u2013303. (https:\/\/doi.org\/10.1159\/000509183)"},{"key":"bib10","series-title":"Clin Endocrinol","first-page":"669","article-title":"Multinodular goitre is a gateway for molecular testing of DICER1 syndrome","volume":"91","author":"Oliver\u2010Petit I","year":"2019","unstructured":"Oliver\u2010Petit I\n, \nBertozzi AI\n, \nGrunenwald S\n, et al.\n Multinodular goitre is a gateway for molecular testing of DICER1 syndrome. Clin Endocrinol 2019 91 669\u2013675. (https:\/\/doi.org\/10.1111\/cen.14074)"},{"key":"bib11","series-title":"J Clin Investig","first-page":"1479","article-title":"DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis","volume":"130","author":"Rivera B","year":"2020","unstructured":"Rivera B\n, \nNadaf J\n, \nFahiminiya S\n, et al.\n DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis. J Clin Investig 2020 130 1479\u20131490. (https:\/\/doi.org\/10.1172\/jci130206)"},{"key":"bib12","series-title":"J Clin Endocrinol Metab","first-page":"3265","article-title":"Whole-genome sequencing of follicular thyroid carcinomas reveal recurrent mutations in MicroRNA processing subunit DGCR8","volume":"106","author":"Paulsson JO","year":"2021","unstructured":"Paulsson JO\n, \nRafati N\n, \nDiLorenzo S\n, et al.\n Whole-genome sequencing of follicular thyroid carcinomas reveal recurrent mutations in MicroRNA processing subunit DGCR8. J Clin Endocrinol Metab 2021 106 3265\u20133282. (https:\/\/doi.org\/10.1210\/clinem\/dgab471)"},{"key":"bib13","series-title":"Int J Mol Sci","first-page":"14812","article-title":"DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions","volume":"23","author":"Rodrigues L","year":"2022","unstructured":"Rodrigues L\n, \nCanberk S\n, \nMacedo S\n, et al.\n DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions. Int J Mol Sci 2022 23 14812. (https:\/\/doi.org\/10.3390\/ijms232314812)"},{"key":"bib14","series-title":"Endocr Pathol","first-page":"25","article-title":"The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasms","volume":"35","author":"Canberk S","year":"2024","unstructured":"Canberk S\n, \nGoncalves J\n, \nRios E\n, et al.\n The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasms. Endocr Pathol 2024 35 25\u201339. (https:\/\/doi.org\/10.1007\/s12022-024-09800-9)"},{"key":"bib15","series-title":"Nat Rev Genet","first-page":"597","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol J","year":"2010","unstructured":"Krol J\n, \nLoedige I\n & \nFilipowicz W\n\n. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010 11 597\u2013610. (https:\/\/doi.org\/10.1038\/nrg2843)"},{"key":"bib16","series-title":"Exp Biol Med","first-page":"395","article-title":"Complexity in regulating microRNA biogenesis in cancer","volume":"245","author":"Chen PS","year":"2020","unstructured":"Chen PS\n, \nLin SC\n & \nTsai SJ\n\n. Complexity in regulating microRNA biogenesis in cancer. Exp Biol Med 2020 245 395\u2013401. (https:\/\/doi.org\/10.1177\/1535370220907314)"},{"key":"bib17","series-title":"Methods Mol Biol","first-page":"3","article-title":"MicroRNA biogenesis and cancer","volume":"676","author":"Winter J","year":"2011","unstructured":"Winter J\n & \nDiederichs S\n\n. MicroRNA biogenesis and cancer. Methods Mol Biol 2011 676 3\u201322. (https:\/\/doi.org\/10.1007\/978-1-60761-863-8_1)"},{"key":"bib18","series-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub","first-page":"205","article-title":"MicroRNA biogenesis, functionality and cancer relevance","volume":"150","author":"Kusenda B","year":"2006","unstructured":"Kusenda B\n, \nMraz M\n, \nMayer J\n, et al.\n MicroRNA biogenesis, functionality and cancer relevance. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2006 150 205\u2013215. (https:\/\/doi.org\/10.5507\/bp.2006.029)"},{"key":"bib19","series-title":"Nature","first-page":"834","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu J","year":"2005","unstructured":"Lu J\n, \nGetz G\n, \nMiska EA\n, et al.\n MicroRNA expression profiles classify human cancers. Nature 2005 435 834\u2013838. (https:\/\/doi.org\/10.1038\/nature03702)"},{"key":"bib20","series-title":"Proc Natl Acad Sci U S A","first-page":"2257","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia S","year":"2006","unstructured":"Volinia S\n, \nCalin GA\n, \nLiu CG\n, et al.\n A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006 103 2257\u20132261. (https:\/\/doi.org\/10.1073\/pnas.0510565103)"},{"key":"bib21","series-title":"Cell","first-page":"112","article-title":"Phosphorylation of the human microRNA-generating complex mediates MAPK\/Erk signaling","volume":"139","author":"Paroo Z","year":"2009","unstructured":"Paroo Z\n, \nYe X\n, \nChen S\n, et al.\n Phosphorylation of the human microRNA-generating complex mediates MAPK\/Erk signaling. Cell 2009 139 112\u2013122. (https:\/\/doi.org\/10.1016\/j.cell.2009.06.044)"},{"key":"bib22","series-title":"Cancer Cell","first-page":"723","article-title":"ERK activation globally downregulates miRNAs through phosphorylating exportin-5","volume":"30","author":"Sun HL","year":"2016","unstructured":"Sun HL\n, \nCui R\n, \nZhou J\n, et al.\n ERK activation globally downregulates miRNAs through phosphorylating exportin-5. Cancer Cell 2016 30 723\u2013736. (https:\/\/doi.org\/10.1016\/j.ccell.2016.10.001)"},{"key":"bib23","series-title":"Surgery","first-page":"155","article-title":"Thyroid nodule molecular profiling: the clinical utility of Afirma Xpression Atlas for nodules with Afirma Genomic Sequencing Classifier-suspicious results","volume":"171","author":"Babazadeh NT","year":"2022","unstructured":"Babazadeh NT\n, \nSinclair TJ\n, \nKrishnamurthy V\n, et al.\n Thyroid nodule molecular profiling: the clinical utility of Afirma Xpression Atlas for nodules with Afirma Genomic Sequencing Classifier-suspicious results. Surgery 2022 171 155\u2013159. (https:\/\/doi.org\/10.1016\/j.surg.2021.08.058)"},{"key":"bib24","series-title":"J Clin Endocrinol Metab","first-page":"1600","article-title":"MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility","volume":"93","author":"Nikiforova MN","year":"2008","unstructured":"Nikiforova MN\n, \nTseng GC\n, \nSteward D\n, et al.\n MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. J Clin Endocrinol Metab 2008 93 1600\u20131608. (https:\/\/doi.org\/10.1210\/jc.2007-2696)"},{"key":"bib25","series-title":"Biophys Rev","first-page":"1081","article-title":"DICER: structure, function, and regulation","volume":"13","author":"Vergani-Junior CA","year":"2021","unstructured":"Vergani-Junior CA\n, \nTonon-da-Silva G\n, \nInan MD\n, et al.\n DICER: structure, function, and regulation. Biophys Rev 2021 13 1081\u20131090. (https:\/\/doi.org\/10.1007\/s12551-021-00902-w)"},{"key":"bib26","series-title":"Virchows Arch","first-page":"105","article-title":"Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study","volume":"485","author":"Condello V","year":"2024","unstructured":"Condello V\n, \nRoberts JW\n, \nStenman A\n, et al.\n Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study. Virchows Arch 2024 485 105\u2013114. (https:\/\/doi.org\/10.1007\/s00428-024-03802-y)"},{"key":"bib27","series-title":"Int J Cancer","first-page":"2030","article-title":"The prevalence of DICER1 pathogenic variation in population databases","volume":"141","author":"Kim J","year":"2017","unstructured":"Kim J\n, \nField A\n, \nSchultz KAP\n, et al.\n The prevalence of DICER1 pathogenic variation in population databases. Int J Cancer 2017 141 2030\u20132036. (https:\/\/doi.org\/10.1002\/ijc.30907)"},{"key":"bib28","series-title":"Hum Mutat","first-page":"1939","article-title":"Ten years of DICER1 mutations: provenance, distribution, and associated phenotypes","volume":"40","author":"de Kock L","year":"2019","unstructured":"de Kock L\n, \nWu MK\n & \nFoulkes WD\n\n. Ten years of DICER1 mutations: provenance, distribution, and associated phenotypes. Hum Mutat 2019 40 1939\u20131953. (https:\/\/doi.org\/10.1002\/humu.23877)"},{"key":"bib29","series-title":"Oncogene","first-page":"5486","article-title":"Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness","volume":"38","author":"Ram\u00edrez-Moya J","year":"2019","unstructured":"Ram\u00edrez-Moya J\n, \nWert-Lamas L\n, \nRiesco-Eizaguirre G\n, et al.\n Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness. Oncogene 2019 38 5486\u20135499. (https:\/\/doi.org\/10.1038\/s41388-019-0804-8)"},{"key":"bib30","series-title":"J Med Genet","first-page":"141","article-title":"A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1","volume":"59","author":"Pont\u00e9n E","year":"2022","unstructured":"Pont\u00e9n E\n, \nFrisk S\n, \nTaylan F\n, et al.\n A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1. J Med Genet 2022 59 141\u2013146. (https:\/\/doi.org\/10.1136\/jmedgenet-2020-107385)"},{"key":"bib31","series-title":"Nature","first-page":"331","article-title":"Structure of the human DICER-pre-miRNA complex in a dicing state","volume":"615","author":"Lee YY","year":"2023","unstructured":"Lee YY\n, \nLee H\n, \nKim H\n, et al.\n Structure of the human DICER-pre-miRNA complex in a dicing state. Nature 2023 615 331\u2013338. (https:\/\/doi.org\/10.1038\/s41586-023-05723-3)"},{"key":"bib32","series-title":"F1000Res","first-page":"214","article-title":"Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma\/DICER1 syndrome: a unique variant of the two-hit tumor suppression model","volume":"4","author":"Brenneman M","year":"2015","unstructured":"Brenneman M\n, \nField A\n, \nYang J\n, et al.\n Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma\/DICER1 syndrome: a unique variant of the two-hit tumor suppression model. F1000Res 2015 4 214. (https:\/\/doi.org\/10.12688\/f1000research.6746.2)"},{"key":"bib33","series-title":"Surg Pathol Clin","first-page":"107","article-title":"On the chopping block: overview of DICER1 mutations in endocrine and neuroendocrine neoplasms","volume":"16","author":"Juhlin CC","year":"2023","unstructured":"Juhlin CC\n\n. On the chopping block: overview of DICER1 mutations in endocrine and neuroendocrine neoplasms. Surg Pathol Clin 2023 16 107\u2013118. (https:\/\/doi.org\/10.1016\/j.path.2022.09.010)"},{"key":"bib34","series-title":"J Clin Endocrinol Metab","first-page":"1614","article-title":"Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study","volume":"102","author":"Khan NE","year":"2017","unstructured":"Khan NE\n, \nBauer AJ\n, \nSchultz KAP\n, et al.\n Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study. J Clin Endocrinol Metab 2017 102 1614\u20131622. (https:\/\/doi.org\/10.1210\/jc.2016-2954)"},{"key":"bib35","series-title":"Genes Dev","first-page":"2700","article-title":"Dicer1 functions as a haploinsufficient tumor suppressor","volume":"23","author":"Kumar MS","year":"2009","unstructured":"Kumar MS\n, \nPester RE\n, \nChen CY\n, et al.\n Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev 2009 23 2700\u20132704. (https:\/\/doi.org\/10.1101\/gad.1848209)"},{"key":"bib36","series-title":"Am J Clin Pathol","first-page":"379","article-title":"Multinodular goiter progression toward malignancy in a case of DICER1 syndrome: histologic and molecular alterations","volume":"149","author":"Gullo I","year":"2018","unstructured":"Gullo I\n, \nBatista R\n, \nRodrigues-Pereira P\n, et al.\n Multinodular goiter progression toward malignancy in a case of DICER1 syndrome: histologic and molecular alterations. Am J Clin Pathol 2018 149 379\u2013386. (https:\/\/doi.org\/10.1093\/ajcp\/aqy004)"},{"key":"bib37","series-title":"J Clin Endocrinol Metab","first-page":"3637","article-title":"Deep sequencing reveals spatially distributed distinct hot spot mutations in DICER1-related multinodular goiter","volume":"101","author":"de Kock L","year":"2016","unstructured":"de Kock L\n, \nBah I\n, \nRevil T\n, et al.\n Deep sequencing reveals spatially distributed distinct hot spot mutations in DICER1-related multinodular goiter. J Clin Endocrinol Metab 2016 101 3637\u20133645. (https:\/\/doi.org\/10.1210\/jc.2016-1328)"},{"key":"bib38","series-title":"Genet Med Open","article-title":"A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance and cancer, thyroid, and other phenotypes in 2 population-scale cohorts","volume":"2","author":"Kim J","year":"2024","unstructured":"Kim J\n, \nHaley J\n, \nHatton JN\n, et al.\n A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance and cancer, thyroid, and other phenotypes in 2 population-scale cohorts. Genet Med Open 2024 2 101846. (https:\/\/doi.org\/10.1016\/j.gimo.2024.101846)"},{"key":"bib39","series-title":"Endocr Pathol","first-page":"437","article-title":"DICER1 mutations occur in more than one-third of follicular-patterned pediatric papillary thyroid carcinomas and correlate with a low-risk disease and female gender predilection","volume":"33","author":"Onder S","year":"2022","unstructured":"Onder S\n, \nMete O\n, \nYilmaz I\n, et al.\n DICER1 mutations occur in more than one-third of follicular-patterned pediatric papillary thyroid carcinomas and correlate with a low-risk disease and female gender predilection. Endocr Pathol 2022 33 437\u2013445. (https:\/\/doi.org\/10.1007\/s12022-022-09736-y)"},{"key":"bib40","series-title":"JAMA Oncol","first-page":"1323","article-title":"Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children","volume":"8","author":"Gallant JN","year":"2022","unstructured":"Gallant JN\n, \nChen SC\n, \nOrtega CA\n, et al.\n Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children. JAMA Oncol 2022 8 1323\u20131327. (https:\/\/doi.org\/10.1001\/jamaoncol.2022.1655)"},{"key":"bib41","series-title":"J Clin Endocrinol Metab","first-page":"2009","article-title":"DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma","volume":"103","author":"Wasserman JD","year":"2018","unstructured":"Wasserman JD\n, \nSabbaghian N\n, \nFahiminiya S\n, et al.\n DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma. J Clin Endocrinol Metab 2018 103 2009\u20132015. (https:\/\/doi.org\/10.1210\/jc.2017-02698)"},{"key":"bib42","series-title":"Endocr Pathol","first-page":"336","article-title":"High prevalence of DICER1 mutations and low frequency of gene fusions in pediatric follicular-patterned tumors of the thyroid","volume":"32","author":"Bae JS","year":"2021","unstructured":"Bae JS\n, \nJung SH\n, \nHirokawa M\n, et al.\n High prevalence of DICER1 mutations and low frequency of gene fusions in pediatric follicular-patterned tumors of the thyroid. Endocr Pathol 2021 32 336\u2013346. (https:\/\/doi.org\/10.1007\/s12022-021-09688-9)"},{"key":"bib43","series-title":"Mod Pathol","first-page":"1264","article-title":"Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations","volume":"33","author":"Chernock RD","year":"2020","unstructured":"Chernock RD\n, \nRivera B\n, \nBorrelli N\n, et al.\n Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations. Mod Pathol 2020 33 1264\u20131274. (https:\/\/doi.org\/10.1038\/s41379-020-0458-7)"},{"key":"bib44","series-title":"Endocr Pathol","first-page":"279","article-title":"DICER1 mutations do not always indicate dismal prognosis in pediatric poorly differentiated thyroid carcinomas","volume":"34","author":"Yegen G","year":"2023","unstructured":"Yegen G\n, \nAltay AY\n, \nY\u0131lmaz \u0130\n, et al.\n DICER1 mutations do not always indicate dismal prognosis in pediatric poorly differentiated thyroid carcinomas. Endocr Pathol 2023 34 279\u2013286. (https:\/\/doi.org\/10.1007\/s12022-023-09780-2)"},{"key":"bib45","series-title":"Am J Surg Pathol","first-page":"1277","article-title":"DICER1 mutations define the landscape of poorly differentiated thyroid carcinoma in children and young adults: case report and literature review","volume":"48","author":"Ver Berne J","year":"2024","unstructured":"Ver Berne J\n, \nVan den Bruel A\n, \nVermeire S\n, et al.\n DICER1 mutations define the landscape of poorly differentiated thyroid carcinoma in children and young adults: case report and literature review. Am J Surg Pathol 2024 48 1277\u20131283. (https:\/\/doi.org\/10.1097\/pas.0000000000002265)"},{"key":"bib46","series-title":"Virchows Arch","first-page":"787","article-title":"Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term \u201cthyroblastoma\u201d more appropriate?","volume":"477","author":"Agaimy A","year":"2020","unstructured":"Agaimy A\n, \nWitkowski L\n, \nStoehr R\n, et al.\n Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term \u201cthyroblastoma\u201d more appropriate? Virchows Arch 2020 477 787\u2013798. (https:\/\/doi.org\/10.1007\/s00428-020-02853-1)"},{"key":"bib47","series-title":"Am J Surg Pathol","first-page":"826","article-title":"Recurrent DICER1 hotspot mutations in malignant thyroid gland teratomas: molecular characterization and proposal for a separate classification","volume":"44","author":"Rooper LM","year":"2020","unstructured":"Rooper LM\n, \nBynum JP\n, \nMiller KP\n, et al.\n Recurrent DICER1 hotspot mutations in malignant thyroid gland teratomas: molecular characterization and proposal for a separate classification. Am J Surg Pathol 2020 44 826\u2013833. (https:\/\/doi.org\/10.1097\/pas.0000000000001430)"},{"key":"bib48","series-title":"Adv Anat Pathol","first-page":"136","article-title":"From malignant thyroid teratoma to thyroblastoma: evolution of a newly-recognized DICER1 -associated malignancy","volume":"30","author":"Rooper LM","year":"2023","unstructured":"Rooper LM\n\n. From malignant thyroid teratoma to thyroblastoma: evolution of a newly-recognized DICER1 -associated malignancy. Adv Anat Pathol 2023 30 136\u2013145. (https:\/\/doi.org\/10.1097\/pap.0000000000000364)"},{"key":"bib49","series-title":"Endocr Relat Cancer","first-page":"295","article-title":"GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours","volume":"27","author":"Paulsson JO","year":"2020","unstructured":"Paulsson JO\n, \nWang N\n, \nGao J\n, et al.\n GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours. Endocr Relat Cancer 2020 27 295\u2013308. (https:\/\/doi.org\/10.1530\/erc-19-0446)"},{"key":"bib50","series-title":"Virchows Arch","first-page":"293","article-title":"Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform","volume":"480","author":"Ghossein CA","year":"2022","unstructured":"Ghossein CA\n, \nDogan S\n, \nFarhat N\n, et al.\n Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform. Virchows Arch 2022 480 293\u2013302. (https:\/\/doi.org\/10.1007\/s00428-021-03212-4)"},{"key":"bib51","series-title":"Clin Cancer Res","first-page":"234","article-title":"Update on pediatric surveillance recommendations for PTEN hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex","volume":"31","author":"Schultz KAP","year":"2025","unstructured":"Schultz KAP\n, \nMacFarland SP\n, \nPerrino MR\n, et al.\n Update on pediatric surveillance recommendations for PTEN hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex. Clin Cancer Res 2025 31 234\u2013244. (https:\/\/doi.org\/10.1158\/1078-0432.ccr-24-1947)"},{"key":"bib52","series-title":"Thyroid","first-page":"1120","article-title":"Predominant DICER1 pathogenic variants in pediatric follicular thyroid carcinomas","volume":"30","author":"Lee YA","year":"2020","unstructured":"Lee YA\n, \nIm SW\n, \nJung KC\n, et al.\n Predominant DICER1 pathogenic variants in pediatric follicular thyroid carcinomas. Thyroid 2020 30 1120\u20131131. (https:\/\/doi.org\/10.1089\/thy.2019.0233)"},{"key":"bib53","series-title":"Thyroid","first-page":"1225","article-title":"DICER1 variants in pediatric and young adult thyroid nodules","volume":"34","author":"Mastnikova K","year":"2024","unstructured":"Mastnikova K\n, \nBulanova Pekova B\n, \nKuklikova V\n, et al.\n DICER1 variants in pediatric and young adult thyroid nodules. Thyroid 2024 34 1225\u20131233. (https:\/\/doi.org\/10.1089\/thy.2024.0188)"},{"key":"bib54","series-title":"J Clin Endocrinol Metab","first-page":"1","article-title":"DICER1 mutations and differentiated thyroid carcinoma: evidence of a direct association","volume":"101","author":"Rutter MM","year":"2016","unstructured":"Rutter MM\n, \nJha P\n, \nSchultz KA\n, et al.\n DICER1 mutations and differentiated thyroid carcinoma: evidence of a direct association. J Clin Endocrinol Metab 2016 101 1\u20135. (https:\/\/doi.org\/10.1210\/jc.2015-2169)"},{"key":"bib55","series-title":"Endocr Connect","article-title":"Clinical, molecular and radiological characteristics of thyroid nodules with somatic DICER1 mutations in adults","volume":"14","author":"Han Y","year":"2025","unstructured":"Han Y\n, \nLi S\n, \nZhao B\n, et al.\n Clinical, molecular and radiological characteristics of thyroid nodules with somatic DICER1 mutations in adults. Endocr Connect 2025 14 e250125. (https:\/\/doi.org\/10.1530\/ec-25-0125)"},{"key":"bib56","series-title":"Front Endocrinol","article-title":"DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer","volume":"14","author":"Ricarte-Filho JC","year":"2023","unstructured":"Ricarte-Filho JC\n, \nCasado-Medrano V\n, \nReichenberger E\n, et al.\n DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer. Front Endocrinol 2023 14 1083382. (https:\/\/doi.org\/10.3389\/fendo.2023.1083382)"},{"key":"bib57","series-title":"Int J Mol Sci","first-page":"909","article-title":"The role of miRNA in papillary thyroid cancer in the context of miRNA Let-7 family","volume":"17","author":"Perdas E","year":"2016","unstructured":"Perdas E\n, \nStawski R\n, \nNowak D\n, et al.\n The role of miRNA in papillary thyroid cancer in the context of miRNA Let-7 family. Int J Mol Sci 2016 17 909. (https:\/\/doi.org\/10.3390\/ijms17060909)"},{"key":"bib58","series-title":"Cells","first-page":"561","article-title":"Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma","volume":"13","author":"Rodrigues L","year":"2024","unstructured":"Rodrigues L\n, \nDa Cruz Paula A\n, \nSoares P\n, et al.\n Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma. Cells 2024 13 561. (https:\/\/doi.org\/10.3390\/cells13070561)"},{"key":"bib59","series-title":"Int J Genomics","first-page":"5789769","article-title":"Racial differences in expression levels of miRNA machinery-related genes, dicer, drosha, DGCR8, and AGO2, in Asian Korean papillary thyroid carcinoma and comparative validation using the cancer genome atlas","volume":"2017","author":"Kim J","year":"2017","unstructured":"Kim J\n, \nPark WJ\n, \nJeong KJ\n, et al.\n Racial differences in expression levels of miRNA machinery-related genes, dicer, drosha, DGCR8, and AGO2, in Asian Korean papillary thyroid carcinoma and comparative validation using the cancer genome atlas. Int J Genomics 2017 2017 5789769. (https:\/\/doi.org\/10.1155\/2017\/5789769)"},{"key":"bib60","series-title":"JAMA Netw Open","article-title":"A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance, and phenotype","volume":"4","author":"Mirshahi UL","year":"2021","unstructured":"Mirshahi UL\n, \nKim J\n, \nBest AF\n, et al.\n A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance, and phenotype. JAMA Netw Open 2021 4 e210112. (https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.0112)"},{"key":"bib61","series-title":"Gynecol Endocrinol","first-page":"617","article-title":"Virilising Sertoli\u2013Leydig cell tumour associated with thyroid papillary carcinoma: case report and general considerations","volume":"26","author":"Poiana C","year":"2010","unstructured":"Poiana C\n, \nVirtej I\n, \nCarsote M\n, et al.\n Virilising Sertoli\u2013Leydig cell tumour associated with thyroid papillary carcinoma: case report and general considerations. Gynecol Endocrinol 2010 26 617\u2013622. (https:\/\/doi.org\/10.3109\/09513591003686361)"},{"key":"bib62","series-title":"Cancer","first-page":"198","article-title":"Comparison of the clinicopathologic features and prognosis of bilateral versus unilateral multifocal papillary thyroid cancer: an updated study with more than 2000 consecutive patients","volume":"122","author":"Wang W","year":"2016","unstructured":"Wang W\n, \nSu X\n, \nHe K\n, et al.\n Comparison of the clinicopathologic features and prognosis of bilateral versus unilateral multifocal papillary thyroid cancer: an updated study with more than 2000 consecutive patients. Cancer 2016 122 198\u2013206. (https:\/\/doi.org\/10.1002\/cncr.29689)"},{"key":"bib63","series-title":"Langenbecks Arch Surg","first-page":"155","article-title":"Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES)","volume":"399","author":"Sancho JJ","year":"2014","unstructured":"Sancho JJ\n, \nLennard TW\n, \nPaunovic I\n, et al.\n Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES). Langenbecks Arch Surg 2014 399 155\u2013163. (https:\/\/doi.org\/10.1007\/s00423-013-1152-8)"},{"key":"bib64","series-title":"J Mol Pathol","first-page":"264","article-title":"DICER1 tumor syndrome: a retrospective review and future perspectives","volume":"5","author":"Cazzato G","year":"2024","unstructured":"Cazzato G\n, \nCasatta N\n, \nLupo C\n, et al.\n DICER1 tumor syndrome: a retrospective review and future perspectives. J Mol Pathol 2024 5 264\u2013275. (https:\/\/doi.org\/10.3390\/jmp5030019)"},{"key":"bib65","series-title":"Fam Cancer","first-page":"337","article-title":"Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group","volume":"20","author":"Bakhuizen JJ","year":"2021","unstructured":"Bakhuizen JJ\n, \nHanson H\n, \nvan der Tuin K\n, et al.\n Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group. Fam Cancer 2021 20 337\u2013348. (https:\/\/doi.org\/10.1007\/s10689-021-00264-y)"},{"key":"bib66","series-title":"Thyroid","first-page":"547","article-title":"Follicular thyroid carcinoma arising after hematopoietic stem cell transplantation in a child with pleuropulmonary blastoma","volume":"22","author":"Shin SH","year":"2012","unstructured":"Shin SH\n, \nYoon JH\n, \nSon MH\n, et al.\n Follicular thyroid carcinoma arising after hematopoietic stem cell transplantation in a child with pleuropulmonary blastoma. Thyroid 2012 22 547\u2013551. (https:\/\/doi.org\/10.1089\/thy.2011.0161)"},{"key":"bib67","series-title":"Clin Cancer Res","first-page":"5681","article-title":"DICER1-Related tumor predisposition: identification of at-risk individuals and recommended surveillance strategies","volume":"30","author":"Schultz KAP","year":"2024","unstructured":"Schultz KAP\n, \nNelson AT\n, \nMallinger PHR\n, et al.\n DICER1-Related tumor predisposition: identification of at-risk individuals and recommended surveillance strategies. Clin Cancer Res 2024 30 5681\u20135692. (https:\/\/doi.org\/10.1158\/1078-0432.ccr-24-1532)"},{"key":"bib68","series-title":"Eur J Endocrinol","first-page":"321","article-title":"Familial vs sporadic papillary thyroid carcinoma: a matched-case comparative study showing similar clinical\/prognostic behaviour","volume":"170","author":"Pinto AE","year":"2014","unstructured":"Pinto AE\n, \nSilva GL\n, \nHenrique R\n, et al.\n Familial vs sporadic papillary thyroid carcinoma: a matched-case comparative study showing similar clinical\/prognostic behaviour. Eur J Endocrinol 2014 170 321\u2013327. (https:\/\/doi.org\/10.1530\/eje-13-0865)"},{"key":"bib69","series-title":"Diagn Histopathol","first-page":"154","article-title":"Oncocytic thyroid neoplasms: from histology to molecular biology","volume":"25","author":"Canberk S","year":"2019","unstructured":"Canberk S\n, \nLima AR\n, \nCorreia M\n, et al.\n Oncocytic thyroid neoplasms: from histology to molecular biology. Diagn Histopathol 2019 25 154\u2013165. (https:\/\/doi.org\/10.1016\/j.mpdhp.2019.02.002)"},{"key":"bib70","series-title":"Development","first-page":"1895","article-title":"Tet family proteins and 5-hydroxymethylcytosine in development and disease","volume":"139","author":"Tan L","year":"2012","unstructured":"Tan L\n & \nShi YG\n\n. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development 2012 139 1895\u20131902. (https:\/\/doi.org\/10.1242\/dev.070771)"},{"key":"bib71","series-title":"Clin Epigenetics","first-page":"176","article-title":"DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker","volume":"13","author":"Azizgolshani N","year":"2021","unstructured":"Azizgolshani N\n, \nPetersen CL\n, \nChen Y\n, et al.\n DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker. Clin Epigenetics 2021 13 176. (https:\/\/doi.org\/10.1186\/s13148-021-01156-9)"},{"key":"bib72","series-title":"Endocr Pathol","first-page":"359","article-title":"Loss of 5-Hydroxymethylcytosine is an epigenetic hallmark of thyroid carcinomas with TERT promoter mutations","volume":"31","author":"Oishi N","year":"2020","unstructured":"Oishi N\n, \nVuong HG\n, \nMochizuki K\n, et al.\n Loss of 5-Hydroxymethylcytosine is an epigenetic hallmark of thyroid carcinomas with TERT promoter mutations. Endocr Pathol 2020 31 359\u2013366. (https:\/\/doi.org\/10.1007\/s12022-020-09652-z)"},{"key":"bib73","series-title":"Nat Rev Mol Cell Biol","first-page":"417","article-title":"Swiss army knives: non-canonical functions of nuclear Drosha and Dicer","volume":"16","author":"Burger K","year":"2015","unstructured":"Burger K\n & \nGullerova M\n\n. Swiss army knives: non-canonical functions of nuclear Drosha and Dicer. Nat Rev Mol Cell Biol 2015 16 417\u2013430. (https:\/\/doi.org\/10.1038\/nrm3994)"},{"key":"bib74","series-title":"Nat Struct Mol Biol","first-page":"998","article-title":"Argonaute proteins couple chromatin silencing to alternative splicing","volume":"19","author":"Ameyar-Zazoua M","year":"2012","unstructured":"Ameyar-Zazoua M\n, \nRachez C\n, \nSouidi M\n, et al.\n Argonaute proteins couple chromatin silencing to alternative splicing. Nat Struct Mol Biol 2012 19 998\u20131004. (https:\/\/doi.org\/10.1038\/nsmb.2373)"},{"key":"bib75","series-title":"Mol Cell Biol","first-page":"9724","article-title":"Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster","volume":"25","author":"Haussecker D","year":"2005","unstructured":"Haussecker D\n & \nProudfoot NJ\n\n. Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster. Mol Cell Biol 2005 25 9724\u20139733. (https:\/\/doi.org\/10.1128\/mcb.25.21.9724-9733.2005)"},{"key":"bib76","series-title":"Front Endocrinol","article-title":"Epigenomics in hurthle cell neoplasms: filling in the gaps towards clinical application","volume":"12","author":"Canberk S","year":"2021","unstructured":"Canberk S\n, \nLima AR\n, \nPinto M\n, et al.\n Epigenomics in hurthle cell neoplasms: filling in the gaps towards clinical application. Front Endocrinol 2021 12 674666. (https:\/\/doi.org\/10.3389\/fendo.2021.674666)"},{"key":"bib77","series-title":"Hum Pathol","first-page":"9","article-title":"Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors","volume":"81","author":"Jung CK","year":"2018","unstructured":"Jung CK\n, \nKim Y\n, \nJeon S\n, et al.\n Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors. Hum Pathol 2018 81 9\u201317. (https:\/\/doi.org\/10.1016\/j.humpath.2018.04.018)"},{"key":"bib78","series-title":"Epigenetics","first-page":"105","article-title":"The epigenetic regulation of dicer and microRNA biogenesis by panobinostat","volume":"12","author":"Hoffend NC","year":"2017","unstructured":"Hoffend NC\n, \nMagner WJ\n & \nTomasi TB\n\n. The epigenetic regulation of dicer and microRNA biogenesis by panobinostat. Epigenetics 2017 12 105\u2013112. (https:\/\/doi.org\/10.1080\/15592294.2016.1267886)"},{"key":"bib79","series-title":"Biochim Biophys Acta Bioenerg","first-page":"591","article-title":"Molecular and metabolic features of oncocytomas: seeking the blueprints of indolent cancers","volume":"1858","author":"De Luise M","year":"2017","unstructured":"De Luise M\n, \nGirolimetti G\n, \nOkere B\n, et al.\n Molecular and metabolic features of oncocytomas: seeking the blueprints of indolent cancers. Biochim Biophys Acta Bioenerg 2017 1858 591\u2013601. (https:\/\/doi.org\/10.1016\/j.bbabio.2017.01.009)"},{"key":"bib80","series-title":"J Clin Investig","first-page":"625","article-title":"HIF-1\u03b1 promotes autophagic proteolysis of dicer and enhances tumor metastasis","volume":"128","author":"Lai HH","year":"2018","unstructured":"Lai HH\n, \nLi JN\n, \nWang MY\n, et al.\n HIF-1\u03b1 promotes autophagic proteolysis of dicer and enhances tumor metastasis. J Clin Investig 2018 128 625\u2013643. (https:\/\/doi.org\/10.1172\/jci89212)"},{"key":"bib81","series-title":"Cancer Res","first-page":"2570","article-title":"A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells","volume":"68","author":"Ting AH","year":"2008","unstructured":"Ting AH\n, \nSuzuki H\n, \nCope L\n, et al.\n A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Res 2008 68 2570\u20132575. (https:\/\/doi.org\/10.1158\/0008-5472.can-07-6405)"},{"key":"bib82","series-title":"Nat Commun","first-page":"5203","article-title":"Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER","volume":"5","author":"van den Beucken T","year":"2014","unstructured":"van den Beucken T\n, \nKoch E\n, \nChu K\n, et al.\n Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun 2014 5 5203. (https:\/\/doi.org\/10.1038\/ncomms6203)"},{"key":"bib83","series-title":"Virchows Arch","first-page":"755","article-title":"Histological clues of DICER1 mutations in thyroid nodules","volume":"485","author":"Jung CK","year":"2024","unstructured":"Jung CK\n, \nLiu Z\n, \nHirokawa M\n, et al.\n Histological clues of DICER1 mutations in thyroid nodules. Virchows Arch 2024 485 755\u2013757. (https:\/\/doi.org\/10.1007\/s00428-024-03915-4)"},{"key":"bib84","series-title":"J Clin Oncol","first-page":"668","article-title":"Neoplasm risk among individuals with a pathogenic germline variant in DICER1","volume":"37","author":"Stewart DR","year":"2019","unstructured":"Stewart DR\n, \nBest AF\n, \nWilliams GM\n, et al.\n Neoplasm risk among individuals with a pathogenic germline variant in DICER1. J Clin Oncol 2019 37 668\u2013676. (https:\/\/doi.org\/10.1200\/jco.2018.78.4678)"},{"key":"bib85","series-title":"Cancer Cytopathol","first-page":"746","article-title":"Cytomorphologic features of thyroid disease in patients with DICER1 mutations: a report of cytology-histopathology correlation in 7 patients","volume":"128","author":"Darbinyan A","year":"2020","unstructured":"Darbinyan A\n, \nMorotti R\n, \nCai G\n, et al.\n Cytomorphologic features of thyroid disease in patients with DICER1 mutations: a report of cytology-histopathology correlation in 7 patients. Cancer Cytopathol 2020 128 746\u2013756. (https:\/\/doi.org\/10.1002\/cncy.22329)"},{"key":"bib86","series-title":"Pediatr Blood Cancer","article-title":"Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): a report from the International Pleuropulmonary Blastoma\/DICER1 registry","volume":"71","author":"Schoettler PJ","year":"2024","unstructured":"Schoettler PJ\n, \nSmith CC\n, \nNishitani M\n, et al.\n Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): a report from the International Pleuropulmonary Blastoma\/DICER1 registry. Pediatr Blood Cancer 2024 71 e31090. (https:\/\/doi.org\/10.1002\/pbc.31090)"},{"key":"bib87","series-title":"AJNR Am J Neuroradiol","first-page":"626","article-title":"Imaging features of primary intracranial sarcoma with DICER1 mutation: a multicenter case series","volume":"45","author":"Eldaya RW","year":"2024","unstructured":"Eldaya RW\n, \nFagan RJ\n, \nDagher SA\n, et al.\n Imaging features of primary intracranial sarcoma with DICER1 mutation: a multicenter case series. AJNR Am J Neuroradiol 2024 45 626\u2013631. 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