{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:44:57Z","timestamp":1777391097628,"version":"3.51.4"},"reference-count":114,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Marine environment is rich in structurally unique molecules and can be an inspiring source of novel drugs. Currently, six marine-derived drugs are in the market with FDA approval and several more are in the clinical pipeline. Structurally diverse and complex secondary metabolites have been isolated from the marine world and these include sulfated steroids. Biological activities of nearly 150 marine sulfated steroids reported from 1978 to 2017 are compiled and described, namely antimicrobial, antitumor, cardiovascular and antifouling activities. Structure\u2013activity relationship for each activity is discussed.<\/jats:p>","DOI":"10.1530\/jme-17-0252","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T01:20:34Z","timestamp":1515028834000},"page":"T211-T231","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":38,"title":["SULFATION PATHWAYS: Sources and biological activities of marine sulfated steroids"],"prefix":"10.1530","volume":"61","author":[{"given":"Francisca","family":"Carvalhal","sequence":"first","affiliation":[{"name":"1Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"},{"name":"2Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Matosinhos, Portugal"}]},{"given":"Marta","family":"Correia-da-Silva","sequence":"additional","affiliation":[{"name":"1Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"},{"name":"2Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Matosinhos, Portugal"}]},{"given":"Em\u00edlia","family":"Sousa","sequence":"additional","affiliation":[{"name":"1Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"},{"name":"2Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Matosinhos, Portugal"}]},{"given":"Madalena","family":"Pinto","sequence":"additional","affiliation":[{"name":"1Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"},{"name":"2Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Matosinhos, Portugal"}]},{"given":"Anake","family":"Kijjoa","sequence":"additional","affiliation":[{"name":"2Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Matosinhos, Portugal"},{"name":"3ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]}],"member":"416","reference":[{"key":"ref871","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1021\/np010121s","article-title":"Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species","volume":"64","year":"2001","journal-title":"Journal of Natural Products"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0040-4020(01)86375-4","article-title":"Weinbersterol disulfates A and B, antiviral steroid sulfates from the sponge petrosia 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