{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:41:02Z","timestamp":1774507262442,"version":"3.50.1"},"reference-count":164,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>We hypothesize that cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) are involved in the modulation of metabolic regulation of food intake by fatty acids in fish. Therefore, we assessed in rainbow trout (<jats:italic>Oncorhynchus mykiss<\/jats:italic>) the effects of intracerebroventricular treatment with 1\u2009ng\/g of CCK-8 and with 2\u2009ng\/g of GLP-1 on food intake, expression of neuropeptides involved in food intake control and the activity of fatty acid-sensing systems in hypothalamus and hindbrain. Food intake decreased up to 24\u2009h post-treatment to 49.8\u201372.3% and 3.1\u201317.8% for CCK-8 and GLP-1, respectively. These anorectic responses are associated with changes in fatty acid metabolism and an activation of fatty acid-sensing mechanisms in the hypothalamus and hindbrain. These changes occurred in parallel with those in the expression of anorexigenic and orexigenic peptides. Moreover, we observed that the activation of fatty acid sensing and the enhanced anorectic potential elicited by CCK-8 and GLP-1 treatments occurred in parallel with the activation of mTOR and FoxO1 and the inhibition of AMPK\u03b1, BSX and CREB. The results are discussed in the context of metabolic regulation of food intake in fish.<\/jats:p>","DOI":"10.1530\/jme-18-0212","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T16:12:51Z","timestamp":1546531971000},"page":"101-116","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":21,"title":["Effects of CCK-8 and GLP-1 on fatty acid sensing and food intake regulation in trout"],"prefix":"10.1530","volume":"62","author":[{"given":"Cristina","family":"Velasco","sequence":"first","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Laboratorio de Fisiolox\u00eda Animal, Facultade de Biolox\u00eda and Centro de Investigaci\u00f3n Mari\u00f1a, Universidade de Vigo, Vigo, Spain"}]},{"given":"Sara","family":"Comesa\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Laboratorio de Fisiolox\u00eda Animal, Facultade de Biolox\u00eda and Centro de Investigaci\u00f3n Mari\u00f1a, Universidade de Vigo, Vigo, Spain"}]},{"given":"Marta","family":"Conde-Sieira","sequence":"additional","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Laboratorio de Fisiolox\u00eda Animal, Facultade de Biolox\u00eda and Centro de Investigaci\u00f3n Mari\u00f1a, Universidade de Vigo, Vigo, Spain"}]},{"given":"Jes\u00fas M","family":"M\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Laboratorio de Fisiolox\u00eda Animal, Facultade de Biolox\u00eda and Centro de Investigaci\u00f3n Mari\u00f1a, Universidade de Vigo, Vigo, Spain"}]},{"given":"Jos\u00e9 L","family":"Soengas","sequence":"additional","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Laboratorio de Fisiolox\u00eda Animal, Facultade de Biolox\u00eda and Centro de 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