{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:17:31Z","timestamp":1769501851124,"version":"3.49.0"},"reference-count":61,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>The impact of thermal imprinting on the plasticity of the hypothalamic\u2013pituitary\u2013interrenal (HPI) axis and stress response in an adult ectotherm, the gilthead sea bream (<jats:italic>Sparus<\/jats:italic><jats:italic>aurata<\/jats:italic>, L.), during its development was assessed. Fish were reared under 4 thermal regimes, and the resulting adults exposed to acute confinement stress and plasma cortisol levels and genes of the HPI axis were monitored. Changes in immune function, a common result of stress, were also evaluated using histomorphometric measurements of melanomacrophages centers (MMCs) in the head kidney and by monitoring macrophage-related transcripts. Thermal history significantly modified the HPI responsiveness in adult sea bream when eggs and larvae were reared at a higher than optimal temperature (HT, 22\u00b0C), and they had a reduced amplitude in their cortisol response and significantly upregulated pituitary<jats:italic>pomc<\/jats:italic>and head kidney<jats:italic>star<\/jats:italic>transcripts. Additionally, after an acute stress challenge, immune function was modified and the head kidney of adult fish reared during development at high temperatures (HT and LHT, 18\u201322\u00b0C) had a decreased number of MMCs and a significant downregulation of dopachrome tautomerase. Thermal imprinting during development influenced adult sea bream physiology and increased plasma levels of glucose and sodium even in the absence of an acute stress in fish reared under a high\u2013low thermal regime (HLT, 22\u201318\u00b0C). Overall, the results demonstrate that temperature during early development influences the adult HPI axis and immune function in a teleost fish.<\/jats:p>","DOI":"10.1530\/joe-16-0610","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:30:35Z","timestamp":1492561835000},"page":"381-394","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":27,"title":["Thermal imprinting modifies adult stress and innate immune responsiveness in the teleost sea bream"],"prefix":"10.1530","volume":"233","author":[{"given":"Ana Patr\u00edcia","family":"Mateus","sequence":"first","affiliation":[{"name":"1Comparative Molecular and Integrative BiologyCentro de Ci\u00eancias do Mar, Universidade do Algarve, Faro, Portugal"},{"name":"2Escola Superior de Sa\u00fadeUniversidade do Algarve, Faro, Portugal"}]},{"given":"Rita A","family":"Costa","sequence":"additional","affiliation":[{"name":"1Comparative Molecular and Integrative BiologyCentro de Ci\u00eancias do Mar, Universidade do Algarve, Faro, Portugal"}]},{"given":"Jo\u00e3o C R","family":"Cardoso","sequence":"additional","affiliation":[{"name":"1Comparative Molecular and Integrative BiologyCentro de Ci\u00eancias do Mar, Universidade do Algarve, Faro, Portugal"}]},{"given":"Karl B","family":"Andree","sequence":"additional","affiliation":[{"name":"3IRTA-SCRUnitat de Cultius Aq\u00fcicoles, Sant Carles de la R\u00e0pita, Spain"}]},{"given":"Alicia","family":"Est\u00e9vez","sequence":"additional","affiliation":[{"name":"3IRTA-SCRUnitat de Cultius Aq\u00fcicoles, Sant Carles de la R\u00e0pita, Spain"}]},{"given":"Enric","family":"Gisbert","sequence":"additional","affiliation":[{"name":"3IRTA-SCRUnitat de Cultius Aq\u00fcicoles, Sant Carles de la R\u00e0pita, Spain"}]},{"given":"Deborah M","family":"Power","sequence":"additional","affiliation":[{"name":"1Comparative Molecular and Integrative BiologyCentro de Ci\u00eancias do Mar, Universidade do Algarve, Faro, Portugal"}]}],"member":"416","reference":[{"key":"2017053117301717000_233.3.381.1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2761.2003.00485.x"},{"key":"2017053117301717000_233.3.381.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2011.12.031"},{"key":"2017053117301717000_233.3.381.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.03.020"},{"key":"2017053117301717000_233.3.381.4","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1630149"},{"key":"2017053117301717000_233.3.381.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2008.07.002"},{"key":"2017053117301717000_233.3.381.6","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/42.3.517"},{"key":"2017053117301717000_233.3.381.7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2109.2004.01202.x","article-title":"Effects of chronic confinement on physiological responses of juvenile gilthead sea bream, Sparus aurata L., to acute handling","volume":"36","author":"Barton","year":"2005","journal-title":"Aquaculture Research"},{"key":"2017053117301717000_233.3.381.8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12864-015-1503-7","article-title":"Temperature during early development has long-term effects on microRNA expression in Atlantic cod","volume":"16","author":"Bizuayehu","year":"2015","journal-title":"BMC Genomics"},{"key":"2017053117301717000_233.3.381.9","doi-asserted-by":"crossref","unstructured":"Boglione C Costa C 2011 Skeletal deformities and juvenile quality. 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