{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T23:19:19Z","timestamp":1767568759102,"version":"3.48.0"},"reference-count":157,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,9]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Maternal obesity impairs uterine function, compromising embryo implantation and pregnancy establishment, posing also long-term risks to offspring health. We explore the contribution of impaired decidualisation to failed embryo implantation and placentation in obese mothers, highlighting the role of altered uterine leptin signalling in the dysregulation of extracellular matrix remodelling, vascularisation and cell proliferation and differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Obesity drastically affects maternal health and reproductive outcomes, being often associated with endocrine imbalance, compromised ovarian function and pregnancy complications. The plastic nature of pregnancy may render the developing foetus particularly vulnerable to oscillations in maternal metabolism, ultimately shaping the health trajectories of the offspring. Presently, we discuss the effect of maternal obesity on decidualisation, a critical step for embryo implantation and placental development. Decidualisation encompasses the differentiation of endometrial stromal cells into specialised decidua. Impaired decidualisation was linked to pregnancy complications, and recent studies suggest that maternal obesity has a detrimental effect on decidualisation. Leptin, an adipokine significantly increased in the circulation of obese women, is known to regulate endometrial function and decidualisation, modulating immune response, angiogenesis and cell proliferation. Furthermore, hyperleptinaemia in obese mothers was linked to altered leptin signalling in the uterus and compromised endometrial function. In this review, we explore the underlying molecular mechanisms linking altered uterine leptin signalling to impaired decidualisation and early pregnancy complications in obese mothers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0319","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T13:55:24Z","timestamp":1733752524000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":0,"title":["Altered uterine leptin signalling in obese mothers: from impaired decidualisation to pregnancy complications"],"prefix":"10.1093","volume":"169","author":[{"given":"Edyta","family":"Walewska","sequence":"first","affiliation":[{"name":"Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland"},{"name":"Epigenetics Programme, The Babraham Institute, Cambridge, UK"}]},{"given":"Zahra","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK"}]},{"given":"Vicente","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-3071","authenticated-orcid":true,"given":"Ant\u00f3nio","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland"},{"name":"Epigenetics Programme, The Babraham Institute, Cambridge, UK"},{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK"},{"name":"Centre for Trophoblast Research, University of Cambridge, Cambridge, UK"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Mol Hum Reprod","first-page":"792","article-title":"Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2\/STAT3 signaling pathway","volume":"21","author":"Ahn JH","year":"2015","unstructured":"Ahn JH, Choi YS & Choi JH 2015 Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2\/STAT3 signaling pathway. 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