{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:27:21Z","timestamp":1735968441913,"version":"3.32.0"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91749205"],"award-info":[{"award-number":["91749205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Quant. Biol."],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>COVID\u201019 is now rapidly spreading worldwide. While the majority of COVID\u201019 patients show only mild or moderate symptoms, some could deteriorate quickly and may succumb to a sudden death. It is therefore important to identify who will be more likely to develop severe outcomes and be treated with particular or preventive care. Here in this literature survey, we collected epidemiologic and clinical data from 36 articles on 51,270 patients with different severity of COVID\u201019, aiming to characterize the population that are prone to severe condition and bad outcomes. These data reveal that old males and those with high BMI or underlying diseases, especially cardiovascular disease, hypertension and diabetes, are overrepresented among severe cases. High leukocyte and lymphopenia are common features in severe and critical patients. Upon deterioration of the disease, both CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells are decreased, while almost all serum cytokines, especially pro\u2010inflammatory cytokines, increased.<\/jats:p>","DOI":"10.15302\/j-qb-020-0230","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T10:43:01Z","timestamp":1612521781000},"page":"23-46","source":"Crossref","is-referenced-by-count":0,"title":["A digitized catalog of COVID\u201019 epidemiology data"],"prefix":"10.1002","volume":"9","author":[{"given":"Wanyu","family":"Tao","sequence":"first","affiliation":[{"name":"Peking\u2010Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Center for Quantitative Biology (CQB) Peking University Beijing 100871 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Peking\u2010Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Center for Quantitative Biology (CQB) Peking University Beijing 100871 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Dong J.","family":"Han","sequence":"additional","affiliation":[{"name":"Peking\u2010Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Center for Quantitative Biology (CQB) Peking University Beijing 100871 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"WHO. (2020)Coronavirus disease (COVID\u20102019) situation reports. Available from the website of World Health Organization."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30183\u20105"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30558\u20104"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046\u20104053\u20104\u20101"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1001\u20100939.2020.0005"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010020\u20101643\u20108"},{"key":"e_1_2_7_9_2","first-page":"145","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID\u201019) in China","volume":"41","author":"The Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention","year":"2020","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14238"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30079\u20105"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.02.018"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3204"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010020\u201005991\u2010x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30566\u20103"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000000824"},{"key":"e_1_2_7_18_2","first-page":"343","article-title":"Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID\u201019) \u2014 United States, February 12\u2013March 16, 2020","author":"CDC. U. S.","year":"2020","journal-title":"MMWR Morb. Mortal Wkly Rep."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.23.20026963"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_7_22_2","article-title":"Ocular dectection of SARS\u2010CoV\u20102 in 114 cases of COVID\u201019 pneumonia in Wuhan, China: An observational study","author":"Deng C.","year":"2020","journal-title":"SSRN Electronic Journal"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00827"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.01.20029769"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102763"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaa089"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"e_1_2_7_29_2","article-title":"Characteristics and associations with severity in COVID\u201019 Patients: A multicentre cohort study from Jiangsu province, China","author":"Liu S.","year":"2020","journal-title":"SSRN Electronic Journal"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16659"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.19.20025288"},{"key":"e_1_2_7_32_2","article-title":"Characteristics of peripheral lymphocyte subset alteration in 2019\u2010nCoV pneumonia","author":"Wang F.","year":"2020","journal-title":"SSRN Electronic Journal"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.19.20024885"},{"journal-title":"Natl. Sci. Rev.","article-title":"Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID\u201019 patients.","author":"Zhou Y.","key":"e_1_2_7_34_2"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.08.20031229"},{"key":"e_1_2_7_36_2","unstructured":"Liu Y. Zhang C. Huang F. Yang Y. Wang F. Yuan J. Zhang Z. Qin Y. Li X. Zhao D. et al. (2020)2019\u2010novel coronavirus (2019\u2010nCoV) infections trigger an exaggerated cytokine response aggravating lung injury. ChinaXiv 202002.00018v1"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14309"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008280"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.03.20030668"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20995"},{"key":"e_1_2_7_41_2","unstructured":"Kupferschmidt K.andCohen J.(2020)WHO launches global megatrial of the four most promising coronavirus treatments."},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2005073"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2131"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2003717"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh056"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102016\u2010209313"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601896"},{"key":"e_1_2_7_48_2","article-title":"Individual Variation of the SARS\u2010CoV2 Receptor ACE2 Gene Expression and Regulation","author":"Chen J.","year":"2020","journal-title":"Aging Cell"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls068"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.90"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112148\u201020200220\u201000105"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.09.20033118"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306825"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474\u20109726.2010.00608.x"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/52A.4.B190"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp046"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549309008524"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100819\u20102"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.004"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30076\u2010X"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010020\u20100401\u20103"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050828"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010020\u20100530\u20103"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.05.014"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.4.1210"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2004.02415.x"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.01.025"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1477"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep10942"},{"key":"e_1_2_7_70_2","unstructured":"Guideline for the Diagnosis and Treatment of COVID\u201019 (7th version)."},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0228"},{"key":"e_1_2_7_72_2","article-title":"A promising anti\u2010cytokine\u2010storm targeted therapy for COVID\u201019: the artificial\u2010liver blood\u2010purification system.","author":"Zhang Y.","year":"2020","journal-title":"Engineering (Beijing)"}],"container-title":["Quantitative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.15302\/J-QB-020-0230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:56:56Z","timestamp":1735898216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.15302\/J-QB-020-0230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.15302\/J-QB-020-0230"],"URL":"https:\/\/doi.org\/10.15302\/j-qb-020-0230","archive":["Portico"],"relation":{},"ISSN":["2095-4689","2095-4697"],"issn-type":[{"type":"print","value":"2095-4689"},{"type":"electronic","value":"2095-4697"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}