{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:27:36Z","timestamp":1735968456392,"version":"3.32.0"},"reference-count":121,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872798 & U1909208"],"award-info":[{"award-number":["81872798 & U1909208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR21H300001"],"award-info":[{"award-number":["LR21H300001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC0910500"],"award-info":[{"award-number":["2018YFC0910500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Quant. Biol."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Functional characterization of the long noncoding RNAs (lncRNAs) in disease attracts great attention, which results in a limited number of experimentally characterized lncRNAs. The major problems underlying the lack of experimental verifications are considered to come from the significant false\u2010positive assignments and extensive genetic\u2010heterogeneity of disease. These problems are even worse when it comes to the functional characterization in comorbidity (simultaneous\/sequential presence of multiple diseases in a patient, and showing much wider prevalence, poorer treatment\u2010response and longer illness\u2010course than a single disease).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Herein, FCCLnc was developed to characterize lncRNA function by (1) integrating diverse SNPs that were associated with 193 diseases standardized by International Classification of Diseases (ICD\u201011), (2) condition\u2010specific expression of lncRNAs, (3) weighted correlation network of lncRNAs and protein\u2010coding neighboring genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FCCLnc can characterize lncRNA function in both disease and comorbidity by not only controlling false discovery but also tolerating their disease heterogeneity. Moreover, FCCLnc can provide interactive visualization and full download of lncRNA\u2010centered co\u2010expression network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, FCCLnc is unique in characterizing lncRNA function in diverse diseases and comorbidities and is highly expected to emerge to be an indispensable complement to other available tools. FCCLnc is accessible at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/idrblab.org\/fcclnc\/\">https:\/\/idrblab.org\/fcclnc\/<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.15302\/j-qb-021-0247","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T02:01:17Z","timestamp":1623031277000},"page":"411-425","source":"Crossref","is-referenced-by-count":0,"title":["Functional characterization of disease\/comorbidity\u2010associated lncRNA"],"prefix":"10.1002","volume":"9","author":[{"given":"Jing","family":"Tang","sequence":"first","affiliation":[{"name":"<!--1--> College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China"},{"name":"<!--2--> College of Basic Medicine Chongqing Medical University Chongqing 400016 China"}]},{"given":"Yongheng","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--2--> College of Basic Medicine Chongqing Medical University Chongqing 400016 China"}]},{"given":"Jianbo","family":"Fu","sequence":"additional","affiliation":[{"name":"<!--1--> College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China"}]},{"given":"Xianglu","family":"Wu","sequence":"additional","affiliation":[{"name":"<!--3--> Joint International Research Laboratory of Reproductive and Development Department of Reproductive Biology School of Public Health Chongqing Medical University Chongqing 400016 China"}]},{"given":"Zhijie","family":"Han","sequence":"additional","affiliation":[{"name":"<!--1--> College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China"},{"name":"<!--2--> College of Basic Medicine Chongqing Medical University Chongqing 400016 China"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--2--> College of Basic Medicine Chongqing Medical University Chongqing 400016 China"}]},{"given":"Maiyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"<!--2--> College of Basic Medicine Chongqing Medical University Chongqing 400016 China"}]},{"given":"Yingxiong","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--2--> College of Basic Medicine Chongqing Medical University Chongqing 400016 China"},{"name":"<!--3--> Joint International Research Laboratory of Reproductive and Development Department of Reproductive Biology School of Public Health Chongqing Medical University Chongqing 400016 China"}]},{"given":"Yubin","family":"Ding","sequence":"additional","affiliation":[{"name":"<!--3--> Joint International Research Laboratory of Reproductive and Development Department of Reproductive Biology School of Public Health Chongqing Medical University Chongqing 400016 China"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"<!--1--> College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"<!--1--> College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.011"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx232"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby032"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz779"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz621"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10406"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.07.049"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.08.004"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010020\u201000541\u2010z"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2020.104023"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1176934320920562"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010018\u20100267\u20107"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby130"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa105"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1099"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3771"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz061"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz120"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u20101137\u20105"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa755"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky905"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20612"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14421"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1031"},{"key":"e_1_2_9_26_2","first-page":"2838","article-title":"FARNA: knowledgebase of inferred functions of non\u2010coding RNA transcripts.","volume":"45","author":"Alam T.","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3751"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010017\u20101727\u20104"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010016\u20100873\u20108"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010017\u20100666\u2010z"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00420"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz036"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elu036"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010014\u20100125\u2010z"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9364"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2015_464"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.225128.117"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201846955"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15234"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.07.009"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)60240\u20102"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00729"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00127"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00490"},{"key":"e_1_2_9_45_2","first-page":"163","article-title":"Managing medical and psychiatric comorbidity in individuals with major depressive disorder and bipolar disorder.","volume":"24","author":"McIntyre R. S.","year":"2012","journal-title":"Ann Clin Psychiatry"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.116"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010014\u20103462\u2010y"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2017.10.012"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2006.01592.x"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1096"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1051"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky955"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky960"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13196"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00681"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1004"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1270"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1273"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01245"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku988"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00059"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt361"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP07869B"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574893611666160609081155"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa368"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bav082"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks967"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00173"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155290"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep38881"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31205\u2010X"},{"key":"e_1_2_9_72_2","first-page":"D1031","article-title":"Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics.","volume":"48","author":"Wang Y.","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1076"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010019\u20101758\u20104"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.016"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009786\u20107"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010019\u20100550\u20103"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126917"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.042"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12122"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701361104"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep39433"},{"key":"e_1_2_9_84_2","first-page":"927","article-title":"Construction of a long noncoding RNA\u2010mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes.","volume":"43","author":"Leng L.","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60047"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328355cd6c"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20101245"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.07.001"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000163"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20104099\u20109"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130189"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2015.13.1.36"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1080\/21592799.2015.1133266"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20109\u201012"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1317"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1120"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010019\u20102818\u20101"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.001169"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz137"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01526"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13051"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.13429"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010015\u20100586\u20104"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3424"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.05.022"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45981"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201038462\u2010x"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1324"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.001"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010019\u20105497\u20104"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904108116"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1055"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz049"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz081"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa258"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx449"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby127"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20103578\u20109_5"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.01.027"}],"container-title":["Quantitative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.15302\/J-QB-021-0247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:55:19Z","timestamp":1735898119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.15302\/J-QB-021-0247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":121,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.15302\/J-QB-021-0247"],"URL":"https:\/\/doi.org\/10.15302\/j-qb-021-0247","archive":["Portico"],"relation":{},"ISSN":["2095-4689","2095-4697"],"issn-type":[{"type":"print","value":"2095-4689"},{"type":"electronic","value":"2095-4697"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}