{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:58:34Z","timestamp":1770839914113,"version":"3.50.1"},"reference-count":96,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309902"],"award-info":[{"award-number":["2017YFC1309902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671774"],"award-info":[{"award-number":["81671774"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630031"],"award-info":[{"award-number":["81630031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M660847"],"award-info":[{"award-number":["2019M660847"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Quant. Biol."],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>As one of the leading causes of global disability, major depressive disorder (MDD) places a noticeable burden on individuals and society. Despite the great expectation on finding accurate biomarkers and effective treatment targets of MDD, studies in applying functional magnetic resonance imaging (fMRI) are still faced with challenges, including the representational ambiguity, small sample size, low statistical power, relatively high false positive rates, <jats:italic>etc<\/jats:italic>. Thus, reviewing studies with solid methodology may help achieve a consensus on the pathology of MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this systematic review, we screened fMRI studies on MDD through strict criteria to focus on reliable studies with sufficient sample size, adequate control of head motion, and a proper multiple comparison control strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found consistent evidence regarding the dysfunction within and among the default mode network (DMN), the frontoparietal network (FPN), and other brain regions. However, controversy remains, probably due to the heterogeneity of participants and data processing strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Future studies are recommended to apply a comprehensive set of neuro\u2010behavioral measurements, consider the heterogeneity of MDD patients and other potentially confounding factors, apply surface\u2010based neuroscientific network fMRI approaches, and advance research transparency and open science by applying state\u2010of\u2010the\u2010art pipelines along with open data sharing.<\/jats:p><\/jats:sec>","DOI":"10.15302\/j-qb-021-0270","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T08:29:26Z","timestamp":1679473766000},"page":"366-380","source":"Crossref","is-referenced-by-count":10,"title":["Altered cerebral activities and functional connectivity in depression: a systematic review of fMRI studies"],"prefix":"10.1002","volume":"10","author":[{"given":"Xue\u2010Ying","family":"Li","sequence":"first","affiliation":[{"name":"<!--1--> CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing 100101 China"},{"name":"<!--2--> Sino\u2010Danish College University of Chinese Academy of Sciences Beijing 101400 China"},{"name":"<!--3--> Sino\u2010Danish Center for Education and Research Beijing 101400 China"},{"name":"<!--4--> CFIN and PET Center Aarhus University N\u00f8rrebrogade 44 8000 Aarhus Denmark"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"<!--1--> CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing 100101 China"},{"name":"<!--5--> Magnetic Resonance Imaging Research Center Institute of Psychology Chinese Academy of Sciences Beijing 100101 China"},{"name":"<!--6--> International Big\u2010Data Center for Depression Research Chinese Academy of Sciences Beijing 100101 China"},{"name":"<!--7--> Department of Psychology University of Chinese Academy of Sciences Beijing 100049 China"}]},{"given":"Chao\u2010Gan","family":"Yan","sequence":"additional","affiliation":[{"name":"<!--1--> CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing 100101 China"},{"name":"<!--5--> Magnetic Resonance Imaging Research Center Institute of Psychology Chinese Academy of Sciences Beijing 100101 China"},{"name":"<!--6--> International Big\u2010Data Center for Depression Research Chinese Academy of Sciences Beijing 100101 China"},{"name":"<!--7--> Department of Psychology University of Chinese Academy of Sciences Beijing 100049 China"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3826"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30925\u20109"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390170113024"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.04.026"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u201000726\u2010z"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020124"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3475"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562\u2010019\u20100655\u2010x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.020"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.004"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010018\u20100065\u2010y"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602413113"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00765.2017"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23843"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.044"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602413113"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1191\/0962280203sm341ra"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101016320"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000596"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2011.01702.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.158"},{"key":"e_1_2_8_25_2","first-page":"2415","article-title":"Anatomical and functional brain abnormalities in unmedicated major depressive disorder.","volume":"11","author":"Yang X.","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsw100"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.342"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5460"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23097"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16080883"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.06.010"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000733"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040430"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16010111"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13415\u2010018\u20100564\u2010x"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.07.026"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx366"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201032521\u2010z"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S165295"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001335"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.22859"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.074"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.064"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.18070870"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.155"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.180118"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100574\u20102"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa106"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00050"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.07.002"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.015"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.039"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.01.006"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.08.011"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.09.005"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201008944\u20105"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.10.028"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.02.001"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17101124"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx273"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20100327(93)90073\u2010S"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030303"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010016\u20109299\u20104"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900390116"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.06.025"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373\u201015.2015"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116287"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117185"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.020"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.020"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu043"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32835ab46d"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2012.06751.x"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.4324\/9781351058513"},{"key":"e_1_2_8_78_2","first-page":"3","volume-title":"Handbook of Emotion Regulation","author":"Gross J. J.","year":"2007"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00923"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12439"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.024"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116715"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.121208.131305"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2783"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1177\/1745691613513470"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0039400"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1177\/1745691617690042"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010050718\u2010095710"},{"key":"e_1_2_8_90_2","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \u201cpipeline\u201d data analysis of resting\u2010state fMRI.","volume":"4","author":"Chao\u2010Gan Y.","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.05.005"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4502"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102163"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133775"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801582115"}],"container-title":["Quantitative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.15302\/J-QB-021-0270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:54:12Z","timestamp":1735898052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.15302\/J-QB-021-0270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.15302\/J-QB-021-0270"],"URL":"https:\/\/doi.org\/10.15302\/j-qb-021-0270","archive":["Portico"],"relation":{},"ISSN":["2095-4689","2095-4697"],"issn-type":[{"value":"2095-4689","type":"print"},{"value":"2095-4697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}