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Biol."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>DNA methylation is a key heritable epigenetic modification that plays a crucial role in transcriptional regulation and therefore a broad range of biological processes. The complex patterns of DNA methylation highlight the significance of the profiling the DNA methylation landscape.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this review, the main high\u2010throughput detection technologies are summarized, and then the three trends of computational estimation of DNA methylation levels were analyzed, especially the expanding of the methylation data with lower coverage. Furthermore, the detection methods of differential methylation patterns for sequencing and array data were presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More and more research indicated the great importance of DNA methylation changes across different diseases, such as cancers. Although a lot of enormous progress has been made in understanding the role of DNA methylation, only few methylated genes or functional elements serve as clinically relevant cancer biomarkers. The bottleneck in DNA methylation advances has shifted from data generation to data analysis. Therefore, it is meaningful to develop machine learning models for computational estimation of methylation profiling and identify the potential biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.15302\/j-qb-022-0289","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T05:39:18Z","timestamp":1639633158000},"page":"55-66","source":"Crossref","is-referenced-by-count":2,"title":["The progress on the estimation of DNA methylation level and the detection of abnormal methylation"],"prefix":"10.1002","volume":"10","author":[{"given":"Shicai","family":"Fan","sequence":"first","affiliation":[{"name":"<!--1--> Shenzhen Institute for Advanced Study University of Electronic Science and Technology of China Shenzhen 518110 China"},{"name":"<!--2--> School of Automation Engineering University of Electronic Science and Technology of China Chengdu 611731 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Likun","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--3--> Institute of Systems Biomedicine Beijing Key Laboratory of Tumor Systems Biology, Department of Pathology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Liang","sequence":"additional","affiliation":[{"name":"<!--4--> Cancer Center Sichuan Provincial People\u2019s Hospital University of Electronic Science and Technology of China Chengdu 611731 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Cao","sequence":"additional","affiliation":[{"name":"<!--5--> Department of Geriatric Endocrinology Sichuan Provincial People\u2019s Hospital University of Electronic Science and Technology of China Chengdu 611731 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiong","family":"Tang","sequence":"additional","affiliation":[{"name":"<!--2--> School of Automation Engineering University of Electronic Science and Technology of China Chengdu 611731 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Tian","sequence":"additional","affiliation":[{"name":"<!--2--> School of Automation Engineering University of Electronic Science and Technology of China Chengdu 611731 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