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Biol."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>As parts of the cis\u2010regulatory mechanism of the human genome, interactions between distal enhancers and proximal promoters play a crucial role. Enhancers, promoters, and enhancer\u2010promoter interactions (EPIs) can be detected using many sequencing technologies and computation models. However, a systematic review that summarizes these EPI identification methods and that can help researchers apply and optimize them is still needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this review, we first emphasize the role of EPIs in regulating gene expression and describe a generic framework for predicting enhancer\u2010promoter interaction. Next, we review prediction methods for enhancers, promoters, loops, and enhancer\u2010promoter interactions using different data features that have emerged since 2010, and we summarize the websites available for obtaining enhancers, promoters, and enhancer\u2010promoter interaction datasets. Finally, we review the application of the methods for identifying EPIs in diseases such as cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The advance of computer technology has allowed traditional machine learning, and deep learning methods to be used to predict enhancer, promoter, and EPIs from genetic, genomic, and epigenomic features. In the past decade, models based on deep learning, especially transfer learning, have been proposed for directly predicting enhancer\u2010promoter interactions from DNA sequences, and these models can reduce the parameter training time required of bioinformatics researchers. We believe this review can provide detailed research frameworks for researchers who are beginning to study enhancers, promoters, and their interactions.<\/jats:p><\/jats:sec>","DOI":"10.15302\/j-qb-022-0322","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T01:30:41Z","timestamp":1678411841000},"page":"122-142","source":"Crossref","is-referenced-by-count":3,"title":["Computational methods for identifying enhancer\u2010promoter interactions"],"prefix":"10.1002","volume":"11","author":[{"given":"Haiyan","family":"Gong","sequence":"first","affiliation":[{"name":"<!--1--> School of Computer and Communication Engineering Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer and Communication Engineering Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Tang","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer and Communication Engineering Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghong","family":"Li","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer and Communication Engineering Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sichen","family":"Zhang","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer and Communication Engineering Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Zhang","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer and Communication Engineering Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing 100083 China"},{"name":"<!--3--> Shunde Innovation School University of Science and Technology Beijing Foshan 528399 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"<!--2--> State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences School of Basic Medicine Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100005 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1139\/o03\u2010051"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.06.015"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.01.014"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09753"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.001"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.061"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.019"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3963"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1006"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr468"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13138"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3542"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5279"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21856"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2012.05.001"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001754\u20103"},{"issue":"136","key":"e_1_2_10_18_2","article-title":"Promoter capture Hi\u2010C: high\u2010resolution, genome\u2010wide profiling of promoter interactions.","author":"Schoenfelder S.","year":"2018","journal-title":"J. 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