{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:14:56Z","timestamp":1766398496020,"version":"3.48.0"},"reference-count":0,"publisher":"IMR Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>&lt;strong&gt;Background:&lt;\/strong&gt; Long-term warfarin therapy has been used to decrease thromboembolic events in patients with atrial fibrillation (AF) following bioprosthetic mitral valve replacement (BMVR) and left atrial appendage obliteration (LAAO). A retrospective study was conducted to investigate the efficacy of long-term warfarin or aspirin therapy in patients with AF after BMVR and LAAO. &lt;br \/&gt;&lt;strong&gt;Methods:&lt;\/strong&gt; A total of 215 patients with persistent AF were given anticoagulation therapy with warfarin for the first &lt;br \/&gt;3 months after BMVR and LAAO, continuing warfarin or aspirin therapy according to the surgeon\u2019s preference. A yearly follow-up with patients was performed by telephone or mail for postoperative condition, cerebrovascular, and bleeding events. &lt;br \/&gt;&lt;strong&gt;Results:&lt;\/strong&gt; Seven patients died in the first 3 months after surgery, including 6 patients from heart failure and 1 patient from sudden death. The remaining 208 patients were divided into two groups: warfarin group (n = 84 patients) and aspirin group (n = 124). The patients in the warfarin group were older than those in the aspirin group and had a lower postoperative left ventricular ejection fraction. Other baseline and operative characteristics were similar. The two groups had similar incidence of thromboembolic events (9.5% versus 8.9%, P = .873) and bleeding events\uff087.1% versus 3.2%, &lt;br \/&gt;P = .207). Each group had one intracranial hemorrhage. Eleven patients expired within three months after surgery, 4\uff084.8%) in the warfarin group and 10\uff088.1%\uff09in the aspirin group (P = .411 by Fisher exact test). Cumulative survival was not significantly different in the two groups by Kaplan-Meier analysis (P = .55, log-rank test). &lt;br \/&gt;&lt;strong&gt;Conclusion:&lt;\/strong&gt; At the current time in China, long-term warfarin or aspirin therapy may have no significantly different impact on long-term prognosis after 3 months anticoagulation with warfarin in patients with AF undergoing BMVR and LAAO.<\/jats:p>","DOI":"10.1532\/hsf.1219","type":"journal-article","created":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T22:55:50Z","timestamp":1427583350000},"page":"011","source":"Crossref","is-referenced-by-count":2,"title":["Is Long-term Warfarin Therapy Necessary in Chinese Patients with Atrial Fibrillation after Bioprosthetic Mitral Valve Replacement and Left Atrial Appendage Obliteration?"],"prefix":"10.31083","volume":"18","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chonglei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changqing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2015,4,6]]},"container-title":["The Heart Surgery Forum"],"original-title":[],"link":[{"URL":"http:\/\/journal.hsforum.com\/index.php\/HSF\/article\/viewFile\/1219\/1224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:13:18Z","timestamp":1766398398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/HSF\/18\/1\/10.1532\/hsf.1219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,4,6]]}},"URL":"https:\/\/doi.org\/10.1532\/hsf.1219","relation":{},"ISSN":["1522-6662","1098-3511"],"issn-type":[{"type":"electronic","value":"1522-6662"},{"type":"print","value":"1098-3511"}],"subject":[],"published":{"date-parts":[[2015,4,6]]}}}