{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:15:13Z","timestamp":1766398513763,"version":"3.48.0"},"reference-count":0,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>&lt;strong&gt;Objective&lt;\/strong&gt;: The objective of this study was to evaluate the safety and efficacy of low-intensity warfarin treatment in Chinese patients after mitral valve replacement as well as the rationality of the INR standards of the hospital (The First People\u2019s Hospital of Jining City). &lt;br \/&gt;&lt;strong&gt;Methods&lt;\/strong&gt;: We retrospectively analyzed 270 cases in our hospital from January 2009 to December 2013; 239 patients completed the 5-year follow-up. There were 192 male and &lt;br \/&gt;78 female subjects, age 32-65 years old with a mean age &lt;br \/&gt;51.51 \u00b1 12.12 years old. All eligible candidates received a Carbomedics artificial mechanical valve replacement and were anticoagulated under this hospital\u2019s current guidelines for postoperative anticoagulant therapy mitral valve replacement (INR 1.8-2.5). We analyzed the patient\u2019s regularly recorded prothrombin times (PTs) and the occurrence of anticoagulation-related complications, such as bleeding, thrombosis, and embolism. &lt;br \/&gt;&lt;strong&gt;Results&lt;\/strong&gt;: A follow-up for 239 of 300 patients was performed for 3-60 months. Within this group, one patient died from cerebral hemorrhage, there was 1 case of subcutaneous bleeding, 1 case of epistaxis, 12 cases of gingival bleeding, in 15 menstrual quantity increased, and in 1 case we found cerebral infarction. &lt;br \/&gt;&lt;strong&gt;Conclusion&lt;\/strong&gt;: In conclusion, low-intensity anticoagulation after mitral Carbomedics valve replacement is therapeutically effective and safe. There is room to improve the anticoagulation standard currently used, perhaps at a slightly lower level than this standard suggests. From our research we can formulate individualized treatment plans and effectively reduce the occurrence of complications.<\/jats:p>","DOI":"10.1532\/hsf.1241","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T11:02:03Z","timestamp":1434106923000},"page":"063","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Observation of Postoperative Warfarin Anticoagulation in 300 Patients Undergoing Mitral Valve Replacement with a Carbomedics Mechanical Valve"],"prefix":"10.31083","volume":"18","author":[{"given":"Lianhe","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmeng","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2015,4,28]]},"container-title":["The Heart Surgery Forum"],"original-title":[],"link":[{"URL":"http:\/\/journal.hsforum.com\/index.php\/HSF\/article\/viewFile\/1241\/1252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:13:35Z","timestamp":1766398415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/HSF\/18\/2\/10.1532\/hsf.1241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,4,28]]}},"URL":"https:\/\/doi.org\/10.1532\/hsf.1241","relation":{},"ISSN":["1522-6662","1098-3511"],"issn-type":[{"type":"electronic","value":"1522-6662"},{"type":"print","value":"1098-3511"}],"subject":[],"published":{"date-parts":[[2015,4,28]]}}}