{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:20:21Z","timestamp":1766398821253,"version":"3.48.0"},"reference-count":0,"publisher":"IMR Press","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>Objective: The aim of this study was to observe the impacts of the specific cyclooxygenase-2 inhibitor celecoxib on cardiac structures, functions, and inflammatory factors during the process of pressure overload\u2013induced  myocardial hypertrophy.\r\nMethods: Twenty-four male Sprague Dawley rats were randomly divided into 3 groups: the sham operation group, the surgery group, and the celecoxib group. The model was established according to the abdominal aortic  coarctation method. \r\nResults: At 16 weeks, rats in the celecoxib group were fed a celecoxib-mixed diet (10 mg\/kg) for 8 consecutive weeks. At week 24 after model establishment, the cardiac structures and functions were observed; changes in the levels of tumor necrosis factor (TNF)-\u03b1, transforming growth factor (TGF)-\u03b2, prostaglandin E2 (PGE2), C-reactive protein (CRP), and uric acid (UA) were detected; and the contents of Smad1\/2\/3 proteins (Smad1, Smad2, and Smad3)\u00a0 were determined. Left ventricular mass index, the heart weight\/body weight ratio, and TNF-\u03b1, TGF-\u03b2, PGE2, CRP, and UA levels of the celecoxib group were all significantly decreased relative to those of the surgery group (P &lt; .05); moreover, the cardiac functions were significantly improved compared to those of the surgery group (P &lt; .05). \r\nConclusions: These results show that inflammatory factors are involved in the myocardial hypertrophy process and that celecoxib may reverse myocardial hypertrophy through a variety of pathways.<\/jats:p>","DOI":"10.1532\/hsf.1971","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T16:09:57Z","timestamp":1570637397000},"page":"E432-E437","source":"Crossref","is-referenced-by-count":4,"title":["Impacts of a Specific Cyclooxygenase-2 Inhibitor on Pressure Overload\u2013Induced Myocardial Hypertrophy in Rats"],"prefix":"10.31083","volume":"22","author":[{"given":"Zhixiang","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongde","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinhu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2019,10,9]]},"container-title":["The Heart Surgery Forum"],"original-title":[],"link":[{"URL":"https:\/\/journal.hsforum.com\/index.php\/HSF\/article\/download\/1971\/3893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journal.hsforum.com\/index.php\/HSF\/article\/download\/1971\/3893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:14:46Z","timestamp":1766398486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/HSF\/22\/6\/10.1532\/hsf.1971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,9]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,10,9]]}},"URL":"https:\/\/doi.org\/10.1532\/hsf.1971","relation":{},"ISSN":["1522-6662","1098-3511"],"issn-type":[{"type":"electronic","value":"1522-6662"},{"type":"print","value":"1098-3511"}],"subject":[],"published":{"date-parts":[[2019,10,9]]}}}