{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T20:15:18Z","timestamp":1778444118029,"version":"3.51.4"},"reference-count":0,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>Background: Stem cell implantation has become a promising therapy for heart failure due to coronary heart disease (CHD). CD133+ stem cell therapy, together with increases of vascular endothelial growth factor (VEGF) and other growth hormones, can induce myocardial repair.\nObjective: To prove that VEGF plays a role in cardiac regeneration.\nMethods: Twenty-six patients with CHD and ejection fractions &lt;35% from Harapan Kita Heart and Vascular Center, Jakarta, Indonesia, from 2016 to 2018 were randomized into 2 groups. The treatment group underwent coronary artery bypass graft (CABG) + CD133+ implantation, and the control group underwent CABG only. Six months later, perfusion and myocardial function were assessed by ejection fraction, wall motion score index (WMSI), ventricular dimensions, and scar size using cardiovascular magnetic resonance imaging. VEGF was assessed with enzyme-linked immunosorbent assay.\nResults: There was significant improvement in ejection fraction (8.69% \u00b1 9.49% versus 1.43% \u00b1 7.87%, P = .04), WMSI (0.51 \u00b1 0.48 versus \u20130.01 \u00b1 0.21, P = .003), and scar size (25.46 \u00b1 12.91 versus 27.32\u00a0 \u00b1 12.92 mm, P = .047) and a significant increase in blood VEGF levels\u00a0 (61.05 \u00b1 63.01 versus 19.88 \u00b1 33.78 pg\/mL, P = .01). Improvements in perfusion defects (13.69 \u00b1 5.03 versus 11.53 \u00b1 5.81 P = .32) and ventricular dimensions (\u201327.59 \u00b1 84.48 versus \u201319.08 \u00b1 36.79 mm, P = .06) were not statistically significant.\nConclusion: CD133+ stem cell implantation improves myocardial function. The increase in VEGF levels is expected to continue improving restoration of myocardial function when myocardial perfusion improvement is still not optimal.<\/jats:p>","DOI":"10.1532\/hsf.3763","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T20:50:43Z","timestamp":1627678243000},"page":"E670-E674","source":"Crossref","is-referenced-by-count":6,"title":["CD133+ Stem Cell Therapy Effects on Myocardial Regeneration Through Increased Vascular Endothelial Growth Factor Correlate with Cardiac Magnetic Resonance Imaging Results in Coronary Artery Bypass Graft Surgery Patients with Low Ejection Fraction"],"prefix":"10.31083","volume":"24","author":[{"given":"Tri Wisesa","family":"Soetisna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2021,7,29]]},"container-title":["The Heart Surgery Forum"],"original-title":[],"link":[{"URL":"https:\/\/journal.hsforum.com\/index.php\/HSF\/article\/download\/3763\/6885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journal.hsforum.com\/index.php\/HSF\/article\/download\/3763\/6885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:15:44Z","timestamp":1766398544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/HSF\/24\/4\/10.1532\/hsf.3763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,21]]}},"URL":"https:\/\/doi.org\/10.1532\/hsf.3763","relation":{},"ISSN":["1522-6662","1098-3511"],"issn-type":[{"value":"1522-6662","type":"electronic"},{"value":"1098-3511","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}