{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:41:40Z","timestamp":1759430500086,"version":"build-2065373602"},"reference-count":16,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>&lt;p&gt;&lt;b&gt;Background:&lt;\/b&gt; Cardiopulmonary bypass may cause serious impairment of lung function. It has been reported that administration of mucosolvin can prevent acute respiratory insufficiency through the improvement of pulmonary surfactant.&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Objectives:&lt;\/b&gt; This study aimed to explore the effects of high-dose mucosolvin on infant lungs following cardiopulmonary bypass.&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;\/b&gt; One hundred infants were randomly divided into 2 groups. In Group 1, patients did not receive any respiratory drug perioperatively and underwent conventional mechanical ventilation postoperatively. In Group 2, patients were administered mucosolvin (15 mg\/kg per day) perioperatively, and doxofylline (15 mg\/kg per day) and ipratropium bromide solution (200 ?g) were administrated postoperatively. Mechanical ventilation parameters, pulmonary surfactant-related protein (SP-B), and cytokines were evaluated after induction of anesthesia and 30 minutes, 24 hours, and 48 hours after CPB.&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;\/b&gt; At the end of CPB, all PaO2\/FiO2 values in Group 2 were higher than those in Group 1. Postoperative SP-B levels in Group 1 decreased significantly compared to the baseline value (&lt;i&gt;P&lt;\/i&gt; &lt; .05). There was no significant difference in hospitalization time between both groups, but both mechanical ventilation time and intensive care unit time of infants in Group 2 were significantly shorter than those in group 1 (&lt;i&gt;P&lt;\/i&gt; &lt; .05).&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;\/b&gt;These findings indicate that high-dose mucosolvin has certain protective effects on respiratory functions in infants undergoing heart operations with CPB and that it that has no adverse effects.&lt;\/p&gt;<\/jats:p>","DOI":"10.1532\/hsf98.20101165","type":"journal-article","created":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T21:03:41Z","timestamp":1314047021000},"page":"227","source":"Crossref","is-referenced-by-count":0,"title":["Effects of High-Dose Mucosolvin on Lung Functions in Infant Patients with Cardiopulmonary 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