{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:41:05Z","timestamp":1759430465600,"version":"build-2065373602"},"reference-count":19,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>&lt;p&gt;&lt;b&gt;Background:&lt;\/b&gt; This study aimed to compare clinical and pathologic data for selected patients with congenital heart disease (CHD) and severe pulmonary hypertension (PH) treated with a diagnostic-treatment-and-repair strategy and to compare results for patients with pulmonary vascular disease (PVD) with simple left-to-right shunt CHD with patients with transposition of the great arteries (TGA) and ventricular septal defect (VSD).&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;\/b&gt; Group I comprised 38 patients with simple left-to-right shunt CHD and severe PH; group II included 11 older patients with TGA with VSD and severe PH; and group III comprised 6 autopsy cases of individuals with a normal circulation. The nature of the pulmonary arteries was determined by the Heath-Edwards classification system. All specimens were quantitatively analyzed.&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;\/b&gt; Group I showed 31 patients with a change to grade I, 3 patients were grade II, 3 patients were grade III, and only 1 patient was grade IV. Group II showed 7 patients with a change to grade I, 2 patients were grade II, 1 patient was grade III, and only 1 patient was grade IV. The media wall thickness percentage (%MT), the media wall area percentage (%MS), and arteriole density were significantly higher in groups I and II than in group III. %MS was significantly higher in group II than in group I; no significant differences in %MT and arteriole density could be found between groups I and II.&lt;\/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;\/b&gt; The PVD in these selected patients with CHD and severe PH who were cared for with a diagnostic-treatment-and-repair strategy is generally reversible, and the changes in PVD in the patients with TGA and VSD were similar to those in the patients with simple left-to-right shunt CHD.&lt;\/p&gt;<\/jats:p>","DOI":"10.1532\/hsf98.20111127","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T22:44:09Z","timestamp":1335566649000},"page":"97","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Pathologic Comparison of Simple Left-to-Right Shunt Congenital Heart Disease and Transposition of the Great Arteries with Ventricular Septal Defect"],"prefix":"10.31083","volume":"15","author":[{"given":"Jing-bin","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1136\/heart.89.11.1344","article-title":"Atrial septostomy for pulmonary arterial hypertension","volume":"89","author":"R. 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