{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:14:52Z","timestamp":1766398492309,"version":"3.48.0"},"reference-count":14,"publisher":"IMR Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>Heyde syndrome is a triad of aortic stenosis, acquired coagulopathy, and anemia due to bleeding from intestinal angiodysplasia. Here we describe a case of this syndrome. An 80-year-old woman with severe aortic stenosis was referred to our department for an aortic valve replacement. She suffered from recurrent iron-deficiency anemia and required transfusions every 2 weeks. Gastroscopy and colonoscopy were normal with the exception of angiodysplasia without bleeding in the cecum. After aortic valve replacement her anemia was resolved. She was discharged on postoperative day 22. No transfusions were needed after the procedure. To date, her hemoglobin has remained stable at &gt;10 mg\/dL.<\/jats:p>","DOI":"10.1532\/hsf98.2014370","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T21:49:33Z","timestamp":1415051373000},"page":"258","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Heyde Syndrome: Resolution Following Aortic Valve Replacement"],"prefix":"10.31083","volume":"17","author":[{"given":"Takahiro","family":"Taguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masazumi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Watadani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijiro","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiichi","family":"Takasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taijiro","family":"Sueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"1","first-page":"807","article-title":"Angiodysplasia of the gastrointestinal tract","volume":"88","author":"P. Foutch","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2","first-page":"691","article-title":"Treatment of aortic valve stenosis and gastrointestinal bleeding by transcatheter aortic valve implantation in Heyde syndrome","volume":"12","author":"M. Gul","year":"2012","journal-title":"Anatol J Cardiol"},{"key":"3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1056\/NEJM195807242590416","article-title":"Gastrointestinal bleeding in aortic stenosis","volume":"259","author":"E. Heyde","year":"1958","journal-title":"N Eng J Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-2007-1018495","article-title":"Angiodysplasia in the colon and rectum. Endoscopic morphology, localisation and frequency","volume":"17","author":"W. Hochter","year":"1985","journal-title":"Endoscopy"},{"key":"5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0003-4975(10)62112-1","article-title":"The association of unexplained gastrointestinal bleeding with calcific aortic stenosis","volume":"44","author":"R. King","year":"1987","journal-title":"An Thorac Surg"},{"key":"6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0022-5223(19)37221-6","article-title":"The syndrome of calcific aortic stenosis and gastrointestinal bleeding: resolution following aortic valve replacement","volume":"83","author":"J. Love","year":"1982","journal-title":"J Thorac Cardiovasc Surg"},{"key":"7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S1569-9293(03)00128-2","article-title":"Aortic stenosis and angiodysplasia in the elderly: common things occur commonly?","volume":"2","author":"H. Luckraz","year":"2003","journal-title":"Interactive Cardiovasc Thorac Surg"},{"key":"8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/ageing\/afp019","article-title":"Heyde syndrome: a common diagnosis in older patients with severe aortic stenosis","volume":"38","author":"M. Massyn","year":"2009","journal-title":"Age Ageing"},{"key":"9","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.102.11.1290","article-title":"Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis","volume":"102","author":"F. Pareti","year":"2000","journal-title":"Circulation"},{"key":"10","first-page":"701","article-title":"Heyde's syndrome: a review","volume":"13","author":"G. Pate","year":"2004","journal-title":"J Heart Valve Dis"},{"key":"11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jtcvs.2011.05.034","article-title":"Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome","volume":"144","author":"J. Thompson, 3rd","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1055\/s-2003-44556","article-title":"Shear stress and von Willebrand factor in health and disease","volume":"29","author":"H. Tsai","year":"2003","journal-title":"Semin Thromb Hemost"},{"key":"13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2169\/internalmedicine.43.935","article-title":"Intravascular hemolysis in aortic stenosis","volume":"43","author":"A. Tsuji","year":"2004","journal-title":"Intern Med"},{"key":"14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"A. Vincentelli","year":"2003","journal-title":"N Eng J Med;"}],"container-title":["The Heart Surgery Forum"],"original-title":[],"link":[{"URL":"http:\/\/journal.hsforum.com\/index.php\/HSF\/article\/viewFile\/837\/841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:13:15Z","timestamp":1766398395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/HSF\/17\/5\/10.1532\/HSF98.2014370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1532\/hsf98.2014370","relation":{},"ISSN":["1522-6662","1098-3511"],"issn-type":[{"type":"electronic","value":"1522-6662"},{"type":"print","value":"1098-3511"}],"subject":[],"published":{"date-parts":[[2014,11,3]]}}}