{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:22Z","timestamp":1760244922303},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Hematology"],"published-print":{"date-parts":[[2004,7,1]]},"DOI":"10.1532\/ijh97.04031","type":"journal-article","created":{"date-parts":[[2004,8,3]],"date-time":"2004-08-03T17:36:08Z","timestamp":1091554568000},"page":"52-58","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Relevance of Survivin as a Biomarker in Neoplasms, Especially in Adult T-Cell Leukemias and Acute Leukemias"],"prefix":"10.1007","volume":"80","author":[{"given":"Kazuyuki","family":"Sugahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Harasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tomonaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenn","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sohda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nakagoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin-ichi","family":"Shibasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"E00001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrc968","author":"Altieri, DC","year":"2003","unstructured":"Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer. 2003;3:46-54.","journal-title":"Nat Rev Cancer"},{"key":"E00002","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1091\/mbc.e02-04-0182","author":"Temme, A","year":"2003","unstructured":"Temme A, Rieger M, Reber F, et al. Localization, dynamics, and function of survivin revealed by expression of functional survivin-DsRed fusion proteins in the living cell. Mol Biol Cell. 2003;14: 78-92.","journal-title":"Mol Biol Cell"},{"key":"E00003","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm0897-917","author":"Ambrosini, G","year":"1997","unstructured":"Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997;3: 917-921.","journal-title":"Nat Med"},{"key":"E00004","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood.V97.9.2784","author":"Carter, BZ","year":"2001","unstructured":"Carter BZ, Milella M, Altieri DC, Andreeff M. Cytokine-regulated expression of survivin in myeloid leukemia. Blood. 2001;97: 2784-2790.","journal-title":"Blood"},{"key":"E00005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1182\/blood-2002-08-2554","author":"Schmidt, SM","year":"2003","unstructured":"Schmidt SM, Schag K, Muller MR, et al. Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells. Blood. 2003;102: 571-576.","journal-title":"Blood"},{"key":"E00006","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1172\/JCI200112983","author":"Mesri, M","year":"2001","unstructured":"Mesri M, Wall RW, Li J, Kim RW, Altieri DC. Cancer gene therapy using a survivin mutant adenovirus. J Clin Invest. 2001;108:981-990.","journal-title":"J Clin Invest"},{"key":"E00007","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2141.2001.02902.x","author":"Kamihira, S","year":"2001","unstructured":"Kamihira S, Yamada Y, Hirakata Y, et al. Aberrant expression of caspase cascade regulatory genes in ATL: survivin is an important determinant for prognosis. Br J Haematol. 2001;114:63-69.","journal-title":"Br J Haematol"},{"key":"E00008","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1080\/1042819021000039956","author":"Nakayama, K","year":"2002","unstructured":"Nakayama K, Kamihira S. Survivin an important determinant for prognosis in ATL: a novel biomarker in practical hemato-oncology. Leuk Lymphoma. 2002;43:2249-2255.","journal-title":"Leuk Lymphoma"},{"key":"E00009","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/annonc\/mdg277","author":"Paydas, S","year":"2003","unstructured":"Paydas S, Tanriverdi K, Yavuz S, Disel U, Sahin B, Burgut R. Survivin and aven: two distinct antiapototic signals in acute leukemias. Ann Oncol. 2003;14:1045-1050.","journal-title":"Ann Oncol"},{"key":"E00010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10120-003-0255-2","author":"Miyachi, K","year":"2003","unstructured":"Miyachi K, Sasaki K, Onodera S, et al. Correlation between survivin mRNA expression and lymph node metastasis in gastric cancer. Gastric Cancer. 2003;6:217-224.","journal-title":"Gastric Cancer"},{"key":"E00011","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1207\/S15327914NC4402_12","volume":"44","author":"Hayashibara, T","year":"2002","unstructured":"Hayashibara T, Yamada Y, Nakayama S, et al. Resveratol induces downregulation in survivin expression and apoptosis in HTLV-1-infected cell lines: a prospective agent for ATL chemotherapy. Nutr Cancer. 2002;44:192-201.","journal-title":"Nutr Cancer"},{"key":"E00012","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1006\/bbrc.2001.4708","volume":"282","author":"Mori, N","year":"2001","unstructured":"Mori N, Yamada Y, Hatta T, et al. Expression of survivin in HTLV-1-infected T-cell lines and primary ATL cells. Biochem Biophys Res Commun. 2001;282:1110-1113.","journal-title":"Biochem Biophys Res Commun"},{"key":"E00013","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<128::AID-IJC18>3.0.CO;2-F","volume":"72","author":"Sugahara, K","year":"1997","unstructured":"Sugahara K, Yamada Y, Hiragata Y, et al. Soluble and membrane isoforms of Fas\/CD95 in fresh adult T-cell leukemia (ATL) cells and ATL-cell lines. Int J Cancer. 1997;72:128-132.","journal-title":"Int J Cancer"},{"key":"E00014","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/10428199609054784","author":"Yamada, Y","year":"1996","unstructured":"Yamada Y, Ohmoto Y, Yamamura M, et al. Plasma M-CSF as an indicator of response to chemotherapy in adult T cell leukemia patients. Leuk Lymphoma. 1996;22:457-461.","journal-title":"Leuk Lymphoma"},{"key":"E00015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2257.2003.00503.x","volume":"25","author":"Kamihira, S","year":"2003","unstructured":"Kamihira S, Dateki N, Sugahara K, et al. Significance of HTLV-1 proviral load quantification by real-time PCR as a surrogate marker for HTLV-1-infected cell count. Clin Lab Haematol. 2003; 25:111-117.","journal-title":"Clin Lab Haematol"},{"key":"E00016","first-page":"589","author":"Badran, A","year":"2003","unstructured":"Badran A, Yoshida A, Wano Y, et al. Expression of the antiapoptotic gene survivin in chronic myeloid leukemia. Anticancer Res. 2003;23:589-592.","journal-title":"Anticancer Res"},{"key":"E00017","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02982021","author":"Mori, A","year":"2002","unstructured":"Mori A,Wada H, Nishimura Y, Okamoto T,Takemoto Y, Kakishita E. Expression of the antiapoptosis gene survivin in human leukemia. Int J Hematol. 2002;75:161-165.","journal-title":"Int J Hematol"},{"key":"E00018","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1182\/blood.V100.10.3749","volume":"100","author":"Munzert, G","year":"2002","unstructured":"Munzert G, Kirchner D, Stobbe H, et al. Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-3B\/Rel-regulated inhibitors of apoptosis. Blood. 2002;100:3749-3756.","journal-title":"Blood"},{"key":"E00019","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood.V97.9.2777","volume":"97","author":"Granziero, L","year":"2001","unstructured":"Granziero L, Ghia P, Circosta P, et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia.Blood. 2001;97: 2777-2783.","journal-title":"Blood"},{"key":"E00020","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.leukres.2003.10.013","author":"Nakagawa, Y","year":"2004","unstructured":"Nakagawa Y, Yamaguchi S, Hasegawa M, et al. Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia. Leuk Res. 2004;28:487-494.","journal-title":"Leuk Res"},{"key":"E00021","first-page":"211","author":"Ullmannova, V","year":"2003","unstructured":"Ullmannova V, Haskovec C. The use of housekeeping genes (HKG) as an internal control for the detection of gene expression by quantitative real-time RT-PCR. Folia Biol (Praha). 2003;49: 211-216.","journal-title":"Folia Biol (Praha)"},{"key":"E00022","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2144\/04361ST04","author":"Aerts, JL","year":"2004","unstructured":"Aerts JL, Gonzales MI, Topalian SL. Selection of appropriate control genes to assess expression of tumor antigens using real-time PCR. Biotechniques. 2004;36:84-86.","journal-title":"Biotechniques"},{"key":"E00023","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1182\/blood-2003-03-0880","volume":"102","author":"Schnittger, S","year":"2003","unstructured":"Schnittger S, Weisser M, Schoch C, Hiddemann W, Haferiach T, Kern W. New score predicting for prognosis in PML-RAR, AML-ETO, or CBFB-MYH11 acute myeloid leukemia based on quantification of fusion transcripts. Blood. 2003;102:2746-2755.","journal-title":"Blood"},{"key":"E00024","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0925-5710(97)00077-7","volume":"66","author":"Watanabe, T","year":"1997","unstructured":"Watanabe T. HTLV-1 associated diseases. Int J Hematol. 1997;66: 257-278.","journal-title":"Int J Hematol"},{"key":"E00025","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/BF02983555","author":"Yasunaga, J","year":"2003","unstructured":"Yasunaga J, Matsuoka M. Leukemogenesis of adult T-cell leukemia. Int J Hematol. 2003;78:312-320.","journal-title":"Int J Hematol"}],"container-title":["International Journal of Hematology"],"original-title":[],"link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1532\/IJH97.04031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T12:21:24Z","timestamp":1530188484000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1532\/IJH97.04031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7,1]]}},"alternative-id":["VFN7B997DLEQH0RF"],"URL":"https:\/\/doi.org\/10.1532\/ijh97.04031","relation":{},"ISSN":["0925-5710"],"issn-type":[{"value":"0925-5710","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}