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Epstein-Barr viral DNA in acute large granular lymphocyte (natural killer) leukemic cells. <i>Blood.<\/i> 1992;79:2116-2123."},{"key":"E00006","unstructured":"Sheridan W, Winton EF, Chan WC, et al. Leukemia of non-T lineage natural killer cells. <i>Blood.<\/i> 1988;72:1701-1707."},{"key":"E00007","unstructured":"Fernandez LA, Pope B, Lee C, Zayed E. Aggressive natural killer cell leukemia in an adult with establishment of an NK cell line. <i>Blood.<\/i> 1986;67:925-930."},{"key":"E00008","unstructured":"Li R, Zhou X, Hao H. One case report of aggressive NK cell leukemia and review of the literature. <i>J Leuk Lymphoma.<\/i> 2004;13:295-297."},{"key":"E00009","unstructured":"Zhang X, Hu M, Xu Z. One case report of NK cell large granular lymphocytic leukemia and review of literature. <i>Chin J Pract Int Med.<\/i> 2003;23:44-46."},{"key":"E00010","unstructured":"Pang M, Shi G, Shi N. One case with aggressive NK cell large granular lymphocytic leukemia. <i>Chin J Hematol.<\/i> 2001;22:48."},{"key":"E00011","unstructured":"van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. <i>Leukemia.<\/i> 2003;17:2257-2317."},{"key":"E00012","unstructured":"Sun HS, Su IJ, Lin YC, Chen JS, Fang SY. A 2.6 MB interval on chromosome 6q25.2-q25.3 is commonly deleted in human nasal natural killer\/T-cell lymphoma. <i>Br J Haematol.<\/i> 2003;122:590-599."},{"key":"E00013","unstructured":"Wong KF, Zhang YM, Chan JK. Cytogenetic abnormalities in natural killer cell lymphoma\/leukaemia: is there a consistent pattern? <i>Leuk Lymphoma.<\/i> 1999;34:241-250."},{"key":"E00014","unstructured":"Siu LL, Wong KF, Chan JK, Kwong YL. 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Development of human T and natural killer cells. <i>Blood.<\/i> 1995;85:2654-2670."},{"key":"E00019","unstructured":"Jaffe E, Harris N, Stein H, Vardiman J, eds. <i>World Health Organization Classification of Tumours. Pathology & Genetics:Tumours of Haematopoietic and Lymphoid Tissues.<\/i> Lyon, France: IARC Press; 2001."},{"key":"E00020","unstructured":"Oshimi K. Leukemia and lymphoma of natural killer lineage cells. <i>Int J Hematol.<\/i> 2003;78:18-23."},{"key":"E00021","unstructured":"Jaffe ES, Krenacs L, Kumar S, Kingma DW, Raffeld M. Extranodal peripheral T-cell and NK-cell neoplasms. <i>Am J Clin Pathol.<\/i> 1999;111:S46-S55."},{"key":"E00022","unstructured":"Petrella T, Bagot M, Willemze R, et al. Blastic NK-cell lymphomas (agranular CD4<sup>+<\/sup>CD56<sup>+<\/sup> hematodermic neoplasms): a review. <i>Am J Clin Pathol.<\/i> 2005;123:662-675."},{"key":"E00023","unstructured":"Imamura N, Kusunoki Y, Kawa-Ha K, et al. 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