{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:23:55Z","timestamp":1758403435790},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The site 1 protease, encoded by Mbtps1, mediates the initial cleavage of site 2 protease substrates, including sterol regulatory element binding proteins and CREB\/ATF transcription factors. We demonstrate that a hypomorphic mutation of Mbtps1 called woodrat (wrt) caused hypocholesterolemia, as well as progressive hypopigmentation of the coat, that appears to be mechanistically unrelated. Hypopigmentation was rescued by transgenic expression of wild-type Mbtps1, and reciprocal grafting studies showed that normal pigmentation depended upon both cell-intrinsic or paracrine factors, as well as factors that act systemically, both of which are lacking in wrt homozygotes. Mbtps1 exhibited a maternal-zygotic effect characterized by fully penetrant embryonic lethality of maternal-zygotic wrt mutant offspring and partial embryonic lethality (~40%) of zygotic wrt mutant offspring. Mbtps1 is one of two maternal-zygotic effect genes identified in mammals to date. It functions nonredundantly in pigmentation and embryogenesis.<\/jats:p>","DOI":"10.1534\/g3.112.002196","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T22:05:14Z","timestamp":1334095514000},"page":"499-504","source":"Crossref","is-referenced-by-count":8,"title":["Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic <i>Mbtps1<\/i> Mutation in Mice"],"prefix":"10.1093","volume":"2","author":[{"given":"Sophie","family":"Rutschmann","sequence":"first","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Crozat","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C","family":"Hanselman","sequence":"additional","affiliation":[{"name":"Pfizer Global Research and Development, Department of Cardiovascular Pharmacology, Ann Arbor, Michigan 48105"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana A","family":"Shigeoka","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Brandl","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L","family":"Popkin","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne B","family":"McKay","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Marie Y","family":"Moresco","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Beutler","sequence":"additional","affiliation":[{"name":"Department of Genetics and"},{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"2021041903334004400_bib1","doi-asserted-by":"crossref","first-page":"9674","DOI":"10.1074\/jbc.M900346200","article-title":"Activation of sterol regulatory element-binding protein by the caspase drice in drosophila larvae","volume":"284","author":"Amarneh","year":"2009","journal-title":"J. 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