{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T16:56:11Z","timestamp":1717606571463},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To investigate the association of CLEC16A gene polymorphisms and autoimmune thyroid diseases (AITDs). Six hundred sixty seven Han Chinese patients with AITDs were selected as study subjects, including 417 patients with Graves\u2019 disease (GD), 250 patients with Hashimoto\u2019s thyroiditis (HT) and 301 healthy control patients. Polymerase chain reaction-restriction fragment length polymorphism (RFLP) and the mass spectrometry technique were used to genotype five CLEC16A single-nucleotide polymorphisms (SNPs) (rs12708716, rs12917716, rs12931878, rs2903692, and rs6498169). Higher frequency of G allele of rs6498169 CLEC16A gene in AITDs patients [P = 0.029, odds ratio (OR) 1.29 and 95% confidence interval 1.022\u22121.505] was observed. In addition an association between rs6498169 and HT was observed with statistical significance (P = 0.018, OR 1.335, 95% confidence interval 1.051\u22121.696). Furthermore, the GG haplotype containing the major allele of (rs12708716 and rs6498169) was associated with an increased risk of HT (P = 0.0148, OR 1.344). When patients with HT and controls were compared, results from the dominant and recessive models showed that the genotype frequency of rs6498169 were at borderline levels (P = 0.054 and P = 0.05), and the other four SNPs of CLEC16A gene showed no significant association with AITDs. Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs.<\/jats:p>","DOI":"10.1534\/g3.114.010926","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T18:15:24Z","timestamp":1395425724000},"page":"973-977","source":"Crossref","is-referenced-by-count":9,"title":["Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases"],"prefix":"10.1093","volume":"4","author":[{"given":"Fatuma-Said","family":"Muhali","sequence":"first","affiliation":[{"name":"Clinical Research Center, The First Affiliated Hospital of Medical School of Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China, 710061"},{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-tian","family":"Cai","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The First Affiliated Hospital of Medical School of Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China, 710061"},{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao-li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu","family":"Qin","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The First Affiliated Hospital of Medical School of Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China, 710061"},{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang-tao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-hong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-juan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-an","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The First Affiliated Hospital of Medical School of Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China, 710061"},{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, People\u2019s Republic of China, 201508"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2021042011340545700_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1210\/jc.2008-0718","article-title":"Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese.","volume":"94","author":"Awata","year":"2009","journal-title":"J. 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