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We have established a Drosophila melanogaster model of FASD and have previously shown that developmental ethanol exposure in flies leads to reduced expression of insulin-like peptides (dILPs) and their receptor. In this work, we link that observation to dysregulation of fatty acid metabolism and lipid accumulation. Further, we show that developmental ethanol exposure in Drosophila causes oxidative stress, that this stress is a primary cause of the developmental lethality and delay associated with ethanol exposure, and, finally, that one of the mechanisms by which ethanol increases oxidative stress is through abnormal fatty acid metabolism. These data suggest a previously uncharacterized mechanism by which ethanol causes the symptoms associated with FASD.<\/jats:p>","DOI":"10.1534\/g3.114.015040","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T17:38:43Z","timestamp":1415813923000},"page":"49-59","source":"Crossref","is-referenced-by-count":47,"title":["Developmental Ethanol Exposure Leads to Dysregulation of Lipid Metabolism and Oxidative Stress in <i>Drosophila<\/i>"],"prefix":"10.1093","volume":"5","author":[{"given":"Theresa","family":"Logan-Garbisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Bortolazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, San Jos\u00e9 State University, 1 Washington Square, San Jos\u00e9, California 95192-0100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, San Jos\u00e9 State University, 1 Washington Square, San Jos\u00e9, California 95192-0100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, San Jos\u00e9 State University, 1 Washington Square, San Jos\u00e9, California 95192-0100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Khodabakhshi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, San Jos\u00e9 State University, 1 Washington Square, San Jos\u00e9, California 95192-0100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael L","family":"French","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, San Jos\u00e9 State University, 1 Washington Square, San Jos\u00e9, California 95192-0100"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2021042013470114500_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2217\/17460875.2.4.403","article-title":"Role of lipids in brain injury and diseases.","volume":"2","author":"Adibhatla","year":"2007","journal-title":"Future Lipidol."},{"key":"2021042013470114500_bib2","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1097\/01.ALC.0000100940.95053.72","article-title":"A mouse model of prenatal ethanol exposure using a voluntary drinking paradigm.","volume":"27","author":"Allan","year":"2003","journal-title":"Alcohol. 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