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To better understand the genetic basis of NAFLD, we conducted an expression quantitative trait locus (eQTL) analysis of mice fed a HFHC diet. Two-hundred sixty-five (A\/J \u00d7 C57BL\/6J) F2 male mice were fed a HFHC diet for 8 wk. eQTL analysis was utilized to identify genomic regions that regulate hepatic gene expression of Xbp1s and Socs3. We identified two overlapping loci for Xbp1s and Socs3 on Chr 1 (164.0\u2013185.4 Mb and 174.4\u2013190.5 Mb, respectively) and Chr 11 (41.1\u201373.1 Mb and 44.0\u201368.6 Mb, respectively), and an additional locus for Socs3 on Chr 12 (109.9\u2013117.4 Mb). C57BL\/6J-Chr 11A\/J\/ NaJ mice fed a HFHC diet manifested the A\/J phenotype of increased Xbp1s and Socs3 gene expression (P &amp;lt; 0.05), whereas C57BL\/6J-Chr 1A\/J\/ NaJ mice retained the C57BL\/6J phenotype. In addition, we replicated the eQTLs on Chr 1 and Chr 12 (LOD scores \u22653.5) using mice from the BXD murine reference panel challenged with CCl4 to induce chronic liver injury and fibrosis. We have identified overlapping eQTLs for Xbp1 and Socs3 on Chr 1 and Chr 11, and consomic mice confirmed that replacing the C57BL\/6J Chr 11 with the A\/J Chr 11 resulted in an A\/J phenotype for Xbp1 and Socs3 gene expression. Identification of the genes for these eQTLs will lead to a better understanding of the genetic factors responsible for NAFLD and potentially other hepatic diseases.<\/jats:p>","DOI":"10.1534\/g3.115.016626","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T23:58:29Z","timestamp":1422316709000},"page":"487-496","source":"Crossref","is-referenced-by-count":3,"title":["Identification of eQTLs for Hepatic <i>Xbp1s<\/i> and <i>Socs3<\/i> Gene Expression in Mice Fed a High-Fat, High-Caloric Diet"],"prefix":"10.1093","volume":"5","author":[{"given":"Sarina","family":"Pasricha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Northwestern University, Chicago, Illinois"},{"name":"Department of Internal Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Kenney-Hunt","sequence":"additional","affiliation":[{"name":"Department of Biology and Environmental Science, Westminster College, Fulton, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadereh","family":"Jafari","sequence":"additional","affiliation":[{"name":"Center for Genetic Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea A","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cheverud","sequence":"additional","affiliation":[{"name":"Department of Biology, Loyola University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwestern University, Chicago, Illinois"},{"name":"Department of Internal Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,4,1]]},"reference":[{"key":"2021042013550019500_bib1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.4161\/cc.6.13.4380","article-title":"Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice.","volume":"6","author":"Alevizos","year":"2007","journal-title":"Cell Cycle"},{"key":"2021042013550019500_bib2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cell.2012.08.012","article-title":"Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.","volume":"150","author":"Andreux","year":"2012","journal-title":"Cell"},{"key":"2021042013550019500_bib3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease.","volume":"346","author":"Angulo","year":"2002","journal-title":"N. 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