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The predicted amino acid sequences for the yellow catfish grp78, crt, perk, ire-1\u03b1, and atf-6\u03b1 revealed that the proteins contained all of the structural features that were characteristic of the five genes in other species, including the KDEL motif, signal peptide, sensor domain, and effector domain. mRNAs of the five genes mentioned above were expressed in various tissues, but their mRNA levels varied among tissues. Dietary Cu excess, but not Cu deficiency, activated the chaperones (grp78 and crt) and folding sensors in ER, and the UPR signaling pathways (i.e., perk\u2013eif2\u03b1 and the ire1\u2013xbp1) in a tissue-specific manner. For the first time, our study cloned grp78, crt, perk, ire-1\u03b1, and atf-6\u03b1 genes in yellow catfish and demonstrated their differential expression among tissues. Moreover, the present study also indicated differential regulation of these ER stress\u2013related genes by dietary Cu deficiency and excess, which will be beneficial for us to evaluate effects of dietary Cu levels in fish at the molecular level, based on the upstream pathway of lipid metabolism (the ER) and thus provide novel insights regarding the nutrition of Cu in fish.<\/jats:p>","DOI":"10.1534\/g3.115.019950","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T21:11:07Z","timestamp":1439845867000},"page":"2091-2104","source":"Crossref","is-referenced-by-count":18,"title":["Endoplasmic Reticulum Stress\u2013Related Genes in Yellow Catfish <i>Pelteobagrus fulvidraco<\/i>: Molecular Characterization, Tissue Expression, and Expression Responses to Dietary Copper Deficiency and Excess"],"prefix":"10.1093","volume":"5","author":[{"given":"Yu-Feng","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Freshwater Aquaculture Collaborative Innovative Center of Hubei Province, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Freshwater Aquaculture Collaborative Innovative Center of Hubei Province, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Freshwater Aquaculture Collaborative Innovative Center of Hubei Province, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Freshwater Aquaculture Collaborative Innovative Center of Hubei Province, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2013Xiong","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Freshwater Aquaculture Collaborative Innovative Center of Hubei Province, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Freshwater Aquaculture Collaborative Innovative Center of Hubei Province, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"key":"2021042106540090400_bib1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1017\/S1751731111002199","article-title":"Cloning and characterization of the calreticulin gene in Asian seabass (Lates calcarifer).","volume":"6","author":"Bai","year":"2012","journal-title":"Animal"},{"key":"2021042106540090400_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0166-445X(98)00117-9","article-title":"Toxic levels of dietary copper in Atlantic salmon (Salmo salar L.) parr.","volume":"46","author":"Berntssen","year":"1999","journal-title":"Aquat. 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