{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:17:24Z","timestamp":1770279444317,"version":"3.49.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prospective ventral uterus of the hermaphrodite gonad primordium consists of two pairs of sister cells, with each pair consisting of a proximal \u201c\u03b1\u201d cell and a distal \u201c\u03b2\u201d cell. All four cells initially are competent to become the anchor cell (AC), a unique cell type that acts as the organizer of subsequent uterine and vulval development. However, the \u03b2 cells soon lose this competence and always become ventral uterine precursor cells (VUs), whereas the \u03b1 cells maintain their AC competence longer, until lin-12\/Notch-mediated interactions between them specify one as the AC and the other as a VU. Here, we investigate this asymmetry in developmental potential and VU fate specification between the \u03b1 and \u03b2 sister cells. We find evidence that lin-12 activity contributes to the robustness of \u03b2VU fate at elevated temperature, that the Caenorhabditis elegans Notch paralog glp-1 is not functionally redundant with lin-12 in specifying \u03b2VU fate, and that the activity of POP-1, the sole C. elegans TCF ortholog, influences \u03b2VU fate. We propose a model for how Wnt and LIN-12\/Notch signaling together lead to robust specification of the \u03b2VU fate.<\/jats:p>","DOI":"10.1534\/g3.115.022608","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T23:20:10Z","timestamp":1447197610000},"page":"2775-2782","source":"Crossref","is-referenced-by-count":13,"title":["Influences of LIN-12\/Notch and POP-1\/TCF on the Robustness of Ventral Uterine Cell Fate Specification in<i>Caenorhabditis elegans<\/i>Gonadogenesis"],"prefix":"10.1093","volume":"5","author":[{"given":"Maria D","family":"Sallee","sequence":"first","affiliation":[{"name":"Department of Genetics and Development, Columbia University Medical Center, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Department of Genetics and Development, Columbia University Medical Center, New York 10032"},{"name":"Department of Genetics and Development, Columbia University Medical Center, New York 10032"},{"name":"Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"2021042109554682700_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(87)90128-0","article-title":"glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans.","volume":"51","author":"Austin","year":"1987","journal-title":"Cell"},{"key":"2021042109554682700_bib2","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.4161\/cc.8.13.9024","article-title":"Wnt asymmetry and the terminal division of neuronal progenitors.","volume":"8","author":"Bertrand","year":"2009","journal-title":"Cell Cycle"},{"key":"2021042109554682700_bib3","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1242\/dev.122.7.2129","article-title":"Symmetry breakage in the development of one-armed gonads in nematodes.","volume":"122","author":"F\u00e9lix","year":"1996","journal-title":"Development"},{"key":"2021042109554682700_bib4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.hdy.6800915","article-title":"Robustness and evolution: concepts, insights and challenges from a developmental model system.","volume":"100","author":"F\u00e9lix","year":"2008","journal-title":"Heredity (Edinb)"},{"key":"2021042109554682700_bib5","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1242\/dev.121.12.4275","article-title":"Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.","volume":"121","author":"Fitzgerald","year":"1995","journal-title":"Development"},{"key":"2021042109554682700_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nmeth.2889","article-title":"Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon.","volume":"11","author":"Fr\u00f8kj\u00e6r-Jensen","year":"2014","journal-title":"Nat. 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