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This was not caused by defects in sperm development, but by defects in male mating behavior. The cdc-25.4 mutant males showed various defects during male mating, including contact response, backing, turning, and vulva location. Aberrant turning behavior was the most prominent defect in the cdc-25.4 mutant males. We also found that cdc-25.4 is expressed in many neuronal cells throughout development. The turning defect in cdc-25.4 mutant males was recovered by cdc-25.4 transgenic expression in neuronal cells, suggesting that cdc-25.4 functions in neurons for male mating. However, the neuronal morphology of cdc-25.4 mutant males appeared to be normal, as examined with several neuronal markers. Also, RNAi depletion of wee-1.3, a C. elegans ortholog of Wee1\/Myt1 kinase, failed to suppress the mating defects of cdc-25.4 mutant males. These findings suggest that, for successful male mating, cdc-25.4 does not target cell cycles that are required for neuronal differentiation and development. Rather, cdc-25.4 likely regulates noncanonical substrates in neuronal cells.<\/jats:p>","DOI":"10.1534\/g3.116.036129","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:07:36Z","timestamp":1477354056000},"page":"4127-4138","source":"Crossref","is-referenced-by-count":2,"title":["<i>cdc-25.4<\/i>, a<i>Caenorhabditis elegans<\/i>Ortholog of<i>cdc25<\/i>, Is Required for Male Mating Behavior"],"prefix":"10.1093","volume":"6","author":[{"given":"Sangmi","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yhong-Hee","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"2021042012110104300_bib1","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1534\/g3.114.013649","article-title":"An RNAi-based suppressor screen identifies interactors of the Myt1 ortholog of Caenorhabditis elegans.","volume":"4","author":"Allen","year":"2014","journal-title":"G3 (Bethesda)"},{"key":"2021042012110104300_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gene.10083","article-title":"CDC-25.1 regulates germline proliferation in Caenorhabditis elegans.","volume":"33","author":"Ashcroft","year":"2002","journal-title":"Genesis"},{"key":"2021042012110104300_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-1119(98)00228-5","article-title":"The four cdc25 genes from the nematode Caenorhabditis elegans.","volume":"214","author":"Ashcroft","year":"1998","journal-title":"Gene"},{"key":"2021042012110104300_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/dbio.1998.9135","article-title":"RNA-mediated interference of a cdc25 homolog in Caenorhabditis elegans results in defects in the embryonic cortical membrane, meiosis, and mitosis.","volume":"206","author":"Ashcroft","year":"1999","journal-title":"Dev. 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