{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:41:42Z","timestamp":1789533702792,"version":"build-2803163510"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the intricate host\u2013parasite interactions during malaria infections. In this study, we described a gene encoding erythrocytic ankyrin-1 (Ank-1) which exhibits allelic-dependent heterogeneous phenotypes during malaria infections. We conducted an ENU mutagenesis screen on mice and identified two Ank-1 mutations, one resulting in an amino acid substitution (MRI95845), and the other a truncated Ank-1 protein (MRI96570). Both mutations caused hereditary spherocytosis-like phenotypes and confer differing protection against Plasmodium chabaudi infections. Upon further examination, the Ank-1(MRI96570) mutation was found to inhibit intraerythrocytic parasite maturation, whereas Ank-1(MRI95845) caused increased bystander erythrocyte clearance during infection. This is the first description of allelic heterogeneity in ankyrin-1 from the direct comparison between two Ank-1 mutations. Despite the lack of direct evidence from population studies, this data further supported the protective roles of ankyrin-1 mutations in conferring malaria protection. This study also emphasized the importance of such phenomena in achieving a better understanding of host\u2013parasite interactions, which could be the basis of future studies.<\/jats:p>","DOI":"10.1534\/g3.117.300079","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T21:00:38Z","timestamp":1501189238000},"page":"3133-3144","source":"Crossref","is-referenced-by-count":5,"title":["Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria"],"prefix":"10.1093","volume":"7","author":[{"given":"Hong Ming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis C","family":"Bauer","sequence":"additional","affiliation":[{"name":"Commonwealth Scientific and Industrial Research Organisation, Sydney 2113, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M","family":"Lelliott","sequence":"additional","affiliation":[{"name":"Immunology Frontier Research Center Research Building, Osaka University, Suita, 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W A","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bio21 Institute, Melbourne 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leann","family":"Tilley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bio21 Institute, Melbourne 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J","family":"McMorran","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetan","family":"Burgio","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"2021042012442018300_bib1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/35016636","article-title":"Malaria susceptibility and CD36 mutation.","volume":"405","author":"Aitman","year":"2000","journal-title":"Nature"},{"key":"2021042012442018300_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.actatropica.2005.05.011","article-title":"Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?","volume":"95","author":"Amodu","year":"2005","journal-title":"Acta Trop."},{"key":"2021042012442018300_bib3","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood-2003-11-3820","article-title":"Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait.","volume":"104","author":"Ayi","year":"2004","journal-title":"Blood"},{"key":"2021042012442018300_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1086\/519221","article-title":"Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.","volume":"81","author":"Ayodo","year":"2007","journal-title":"Am. 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