{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:11:16Z","timestamp":1792671076686,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic homeostasis is coordinately controlled by diverse inputs. Understanding these regulatory networks is vital to combating metabolic disorders. The nematode Caenorhabditis elegans has emerged as a powerful, genetically tractable model system for the discovery of lipid regulatory mechanisms. Here we introduce DBL-1, the C. elegans homolog of bone morphogenetic protein 2\/4 (BMP2\/4), as a significant regulator of lipid homeostasis. We used neutral lipid staining and a lipid droplet marker to demonstrate that both increases and decreases in DBL-1\/BMP signaling result in reduced lipid stores and lipid droplet count. We find that lipid droplet size, however, correlates positively with the level of DBL-1\/BMP signaling. Regulation of lipid accumulation in the intestine occurs through non-cell-autonomous signaling, since expression of SMA-3, a Smad signal transducer, in the epidermis (hypodermis) is sufficient to rescue the loss of lipid accumulation. Finally, genetic evidence indicates that DBL-1\/BMP functions upstream of Insulin\/IGF-1 Signaling in lipid metabolism. We conclude that BMP signaling regulates lipid metabolism in C. elegans through interorgan signaling to the Insulin pathway, shedding light on a less well-studied regulatory mechanism for metabolic homeostasis.<\/jats:p>","DOI":"10.1534\/g3.117.300416","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T20:50:20Z","timestamp":1511297420000},"page":"343-351","source":"Crossref","is-referenced-by-count":41,"title":["<i>Caenorhabditis elegans<\/i>\n                    DBL-1\/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling"],"prefix":"10.1093","volume":"8","author":[{"given":"James F","family":"Clark","sequence":"first","affiliation":[{"name":"Ph.D. Program in Biology, The Graduate Center, City University of New York (CUNY), New York, New York 10016"},{"name":"Biology Department, Queens College, CUNY, Flushing, New York 11367"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Meade","sequence":"additional","affiliation":[{"name":"Biology Department, Queens College, CUNY, Flushing, New York 11367"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan","family":"Ranepura","sequence":"additional","affiliation":[{"name":"Biology Department, Queens College, CUNY, Flushing, New York 11367"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Albert Einstein College of Medicine, New York, New York 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Savage-Dunn","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Biology, The Graduate Center, City University of New York (CUNY), New York, New York 10016"},{"name":"Biology Department, Queens College, CUNY, Flushing, New York 11367"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2021042013280643200_bib1","author":"Ashrafi","year":"2007"},{"key":"2021042013280643200_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","article-title":"Role of insulin-like growth factors in embryonic and postnatal growth.","volume":"75","author":"Baker","year":"1993","journal-title":"Cell"},{"key":"2021042013280643200_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0092-8674(00)80799-0","article-title":"Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1\u20134.","volume":"97","author":"Bohni","year":"1999","journal-title":"Cell"},{"key":"2021042013280643200_bib4","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2337\/db08-1458","article-title":"Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.","volume":"58","author":"Bottcher","year":"2009","journal-title":"Diabetes"},{"key":"2021042013280643200_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/biof.1334","article-title":"Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K\/AKT pathway.","volume":"43","author":"Chattopadhyay","year":"2017","journal-title":"Biofactors"},{"key":"2021042013280643200_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08977190412331279890","article-title":"Bone morphogenetic proteins.","volume":"22","author":"Chen","year":"2004","journal-title":"Growth Factors"},{"key":"2021042013280643200_bib7","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.metabol.2005.05.024","article-title":"Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity.","volume":"54","author":"Fain","year":"2005","journal-title":"Metabolism"},{"key":"2021042013280643200_bib8","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1242\/dev.02476","article-title":"An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGF\u03b2 signaling during mesodermal patterning.","volume":"133","author":"Foehr","year":"2006","journal-title":"Development"},{"key":"2021042013280643200_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/genetics\/137.1.107","article-title":"daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.","volume":"137","author":"Gottlieb","year":"1994","journal-title":"Genetics"},{"key":"2021042013280643200_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cub.2006.11.065","article-title":"Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.","volume":"17","author":"Gumienny","year":"2007","journal-title":"Curr. 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