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To investigate the biological mechanisms targeted during domestication, we investigated gene expression in the pituitaries of experimentally domesticated foxes (Vulpes vulpes). RNA was sequenced from the anterior pituitary of six foxes selectively bred for tameness (\u201ctame foxes\u201d) and six foxes selectively bred for aggression (\u201caggressive foxes\u201d). Expression, splicing, and network differences identified between the two lines indicated the importance of genes related to regulation of exocytosis, specifically mediated by cAMP, organization of pseudopodia, and cell motility. These findings provide new insights into biological mechanisms that may have been targeted when these lines of foxes were selected for behavior and suggest new directions for research into HPA axis regulation and the biological underpinnings of domestication.<\/jats:p>","DOI":"10.1534\/g3.117.300508","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T01:35:12Z","timestamp":1517276112000},"page":"859-873","source":"Crossref","is-referenced-by-count":33,"title":["Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes"],"prefix":"10.1093","volume":"8","author":[{"given":"Jessica P","family":"Hekman","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"},{"name":"Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya V","family":"Vladimirova","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimma G","family":"Gulevich","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"},{"name":"Program in Ecology, Evolution, and Conservation Biology, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya V","family":"Kharlamova","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Herbeck","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M","family":"Acland","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University, College of Veterinary Medicine, Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori T","family":"Raetzman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila N","family":"Trut","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V","family":"Kukekova","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"2021042013282813900_bib1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1098\/rspb.1980.0116","article-title":"Molecular evolution of biologically active polypeptides.","volume":"210","author":"Acher","year":"1980","journal-title":"Proc. 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