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Locomotory behavior represents an especially plastic read-out of animal response, with its dynamic dependence on environmental stimuli presenting a challenge for analysis and for understanding the genomic architecture of heritable variation. Here we characterize behavioral reaction norms as thermal performance curves for the nematode Caenorhabditis briggsae, using a collection of 23 wild isolate genotypes and 153 recombinant inbred lines to quantify the extent of genetic and plastic variation in locomotory behavior to temperature changes. By reducing the dimensionality of the multivariate phenotypic response with a function-valued trait framework, we identified genetically distinct behavioral modules that contribute to the heritable variation in the emergent overall behavioral thermal performance curve. Quantitative trait locus mapping isolated regions on Chromosome II associated with locomotory activity at benign temperatures and Chromosome V loci related to distinct aspects of sensitivity to high temperatures, with each quantitative trait locus explaining up to 28% of trait variation. These findings highlight how behavioral responses to environmental inputs as thermal reaction norms can evolve through independent changes to genetically distinct modular components of such complex phenotypes.<\/jats:p>","DOI":"10.1534\/g3.119.400043","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T21:44:11Z","timestamp":1556833451000},"page":"2135-2151","source":"Crossref","is-referenced-by-count":9,"title":["Genetically Distinct Behavioral Modules Underlie Natural Variation in Thermal Performance Curves"],"prefix":"10.1093","volume":"9","author":[{"given":"Gregory W","family":"Stegeman","sequence":"first","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott E","family":"Baird","sequence":"additional","affiliation":[{"name":"Department of Biology, Wright State University, Dayton, Ohio, 45435"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Toronto"},{"name":"Donnelly Centre, University of Toronto, Toronto, Ontario M5S3B2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asher D","family":"Cutter","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2021042014040222200_bib1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004156","article-title":"A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology.","volume":"10","author":"Andersen","year":"2014","journal-title":"PLoS Genet."},{"key":"2021042014040222200_bib2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1086\/648567","article-title":"Thermodynamic effects on organismal performance: is hotter better?","volume":"83","author":"Angilletta","year":"2010","journal-title":"Physiol. 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