{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:58:02Z","timestamp":1788022682093,"version":"build-2784847793"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Binge eating (BE) is a heritable trait associated with eating disorders and involves episodes of rapid, large amounts of food consumption. We previously identified cytoplasmic FMR1-interacting protein 2 (Cyfip2) as a genetic factor underlying compulsive-like BE in mice. CYFIP2 is a homolog of CYFIP1 which is one of four paternally-deleted genes in patients with Type I Prader-Willi Syndrome (PWS), a neurodevelopmental disorder whereby 70% of cases involve paternal 15q11-q13 deletion. PWS symptoms include hyperphagia, obesity (if untreated), cognitive deficits, and obsessive-compulsive behaviors. We tested whether Cyfip1 haploinsufficiency (+\/\u2212) would enhance compulsive-like behavior and palatable food (PF) intake in a parental origin- and sex-dependent manner on two Cyfip2 genetic backgrounds, including the BE-prone C57BL\/6N (Cyfip2N\/N) background and the BE-resistant C57BL\/6J (Cyfip2J\/J) background. Cyfip1+\/\u2212 mice showed increased compulsive-like behavior on both backgrounds and increased PF intake on the Cyfip2N\/N background. In contrast, maternal Cyfip1 haploinsufficiency on the BE-resistant Cyfip2J\/J background induced a robust escalation in PF intake in wild-type Cyfip1J\/J males while having no effect in Cyfip1J\/- males. Notably, induction of behavioral phenotypes in wild-type males following maternal Fmr1+\/\u2212 has previously been reported. In the hypothalamus, there was a paternally-enhanced reduction in CYFIP1 protein whereas in the nucleus accumbens, there was a maternally-enhanced reduction in CYFIP1 protein. Nochange in FMR1 protein (FMRP) was observed in Cyfip1+\/\u2212 mice, regardless of parental origin. To summarize, Cyfip1 haploinsufficiency increased compulsive-like behavior and induced genetic background-dependent, sex-dependent, and parent-of-origin-dependent effects on PF consumption and CYFIP1 expression that could have relevance for neurodevelopmental and neuropsychiatric disorders.<\/jats:p>","DOI":"10.1534\/g3.119.400470","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T22:45:14Z","timestamp":1563576314000},"page":"3009-3022","source":"Crossref","is-referenced-by-count":25,"title":["<i>Cyfip1<\/i>\n                    Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on\n                    <i>Cyfip2<\/i>\n                    Genetic Background, Parent-of Origin, and Sex"],"prefix":"10.1093","volume":"9","author":[{"given":"Richard K","family":"Babbs","sequence":"first","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A","family":"Beierle","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"},{"name":"T32 NIGMS Training Program in Biomolecular Pharmacology"},{"name":"Boston University\u2019s Transformative Training Program in Addiction Science (TTPAS), Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu T","family":"Ruan","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"},{"name":"T32 NIGMS Training Program in Biomolecular Pharmacology"},{"name":"Boston University\u2019s Transformative Training Program in Addiction Science (TTPAS), Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C","family":"Kelliher","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley X","family":"Feng","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola A","family":"Benitez","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred A","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne J","family":"Pierre","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeya","family":"Anandakumar","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, 71 S. 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