{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:40:46Z","timestamp":1772232046962,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Theoretical work predicts that sexual selection can enhance natural selection, increasing the rate of adaptation to new environments and helping purge harmful mutations. While some experiments support these predictions, remarkably little work has addressed the role of sexual selection on compensatory adaptation\u2014populations\u2019 ability to compensate for the costs of deleterious alleles that are already present. We tested whether sexual selection, as well as the degree of standing genetic variation, affect the rate of compensatory evolution via phenotypic suppression in experimental populations of Drosophila melanogaster. These populations were fixed for a spontaneous mutation causing mild abnormalities in the male sex comb, a structure important for mating success. We fine-mapped this mutation to an \u223c85 kb region on the X chromosome containing three candidate genes, showed that the mutation is deleterious, and that its phenotypic expression and penetrance vary by genetic background. We then performed experimental evolution, including a treatment where opportunity for mate choice was limited by experimentally enforced monogamy. Although evolved populations did show some phenotypic suppression of the morphological abnormalities in the sex comb, the amount of suppression did not depend on the opportunity for sexual selection. Sexual selection, therefore, may not always enhance natural selection; instead, the interaction between these two forces may depend on additional factors.<\/jats:p>","DOI":"10.1534\/g3.119.400934","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T21:54:22Z","timestamp":1583186062000},"page":"1541-1551","source":"Crossref","is-referenced-by-count":2,"title":["Sexual Selection Does Not Increase the Rate of Compensatory Adaptation to a Mutation Influencing a Secondary Sexual Trait in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-8413","authenticated-orcid":false,"given":"Christopher H","family":"Chandler","sequence":"first","affiliation":[{"name":"Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI"},{"name":"Department of Biological Sciences, State University of New York at Oswego, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mammel","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI"},{"name":"Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2874-287X","authenticated-orcid":false,"given":"Ian","family":"Dworkin","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI"},{"name":"Department of Biology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"2021042011375126400_bib1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/35079590","article-title":"Sexual selection and the maintenance of sexual reproduction.","volume":"411","author":"Agrawal","year":"2001","journal-title":"Nature"},{"key":"2021042011375126400_bib2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/evo.12238","article-title":"Sexual Selection Can Remove an Experimentally Induced Mutation Load.","volume":"68","author":"Almbro","year":"2014","journal-title":"Evolution"},{"key":"2021042011375126400_bib3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.anbehav.2013.10.005","article-title":"Misalignment of natural and sexual selection among divergently adapted Drosophila melanogaster populations.","volume":"87","author":"Arbuthnott","year":"2014","journal-title":"Anim. 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