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To identify tumor cell-extrinsic (microenvironmental) factors that regulate the ability of metastatic tumor cells to effectively colonize a tissue, we performed a genome-wide screen utilizing the experimental metastasis assay on mutant mice. Mutant and wildtype (control) mice were tail vein-dosed with murine metastatic melanoma B16-F10 cells and 10 days later the number of pulmonary metastatic colonies were counted. Of the 1,300 genes\/genetic locations (1,344 alleles) assessed in the screen 34 genes were determined to significantly regulate pulmonary metastatic colonization (15 increased and 19 decreased; P &amp;lt; 0.005 and genotype effect &amp;lt;-55 or &amp;gt;+55). While several of these genes have known roles in immune system regulation (Bach2, Cyba, Cybb, Cybc1, Id2, Igh-6, Irf1, Irf7, Ncf1, Ncf2, Ncf4 and Pik3cg) most are involved in a disparate range of biological processes, ranging from ubiquitination (Herc1) to diphthamide synthesis (Dph6) to Rho GTPase-activation (Arhgap30 and Fgd4), with no previous reports of a role in the regulation of metastasis. Thus, we have identified numerous novel regulators of pulmonary metastatic colonization, which may represent potential therapeutic targets.<\/jats:p>","DOI":"10.1534\/g3.120.401128","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T23:05:38Z","timestamp":1585955138000},"page":"1869-1877","source":"Crossref","is-referenced-by-count":8,"title":["A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation"],"prefix":"10.1093","volume":"10","author":[{"given":"Louise","family":"van der Weyden","sequence":"first","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Swiatkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-4685","authenticated-orcid":false,"given":"Anneliese O","family":"Speak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-0306","authenticated-orcid":false,"given":"David J","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"2021052006152964400_bib1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41590-019-0549-0","article-title":"High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.","volume":"21","author":"Abeler-D\u00f6rner","year":"2020","journal-title":"Nat. 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