{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:05:36Z","timestamp":1761523536998},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ras-mediated vulval development in C. elegans is inhibited by the functionally redundant sets of class A, B, and C synthetic Multivulva (synMuv) genes. Three of the class B synMuv genes encode an Rb\/DP\/E2F complex that, by analogy with its mammalian and Drosophila counterparts, has been proposed to silence genes required for vulval specification through chromatin modification and remodeling. Two class A synMuv genes, lin-15A and lin-56, encode novel nuclear proteins that appear to function as a complex. We show that a third class A synMuv gene, lin-8, is the defining member of a novel C. elegans gene family. The LIN-8 protein is nuclear and can interact physically with the product of the class B synMuv gene lin-35, the C. elegans homolog of mammalian Rb. LIN-8 likely acts with the synMuv A proteins LIN-15A and LIN-56 in the nucleus, possibly in a protein complex with the synMuv B protein LIN-35 Rb. Other LIN-8 family members may function in similar complexes in different cells or at different stages. The nuclear localization of LIN-15A, LIN-56, and LIN-8, as well as our observation of a direct physical interaction between class A and class B synMuv proteins, supports the hypothesis that the class A synMuv genes control vulval induction through the transcriptional regulation of gene expression.<\/jats:p>","DOI":"10.1534\/genetics.104.034173","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T00:35:44Z","timestamp":1121387744000},"page":"1017-1031","source":"Crossref","is-referenced-by-count":14,"title":["<i>lin-8<\/i>, Which Antagonizes <i>Caenorhabditis elegans<\/i> Ras-Mediated Vulval Induction, Encodes a Novel Nuclear Protein That Interacts With the LIN-35 Rb Protein"],"prefix":"10.1093","volume":"171","author":[{"given":"Ewa M","family":"Davison","sequence":"first","affiliation":[{"name":"Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albertha J M","family":"Walhout","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Vidal","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Robert","family":"Horvitz","sequence":"additional","affiliation":[{"name":"Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"2022010800141616700_BIB1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2022010800141616700_BIB2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/nar\/30.1.276","volume":"30","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2022010800141616700_BIB3","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1242\/dev.128.21.4349","volume":"128","year":"2001","journal-title":"Development"},{"key":"2022010800141616700_BIB4","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0960-9822(02)00844-8","volume":"12","year":"2002","journal-title":"Curr. 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