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Analysis of two cgr-1 loss-of-function mutations indicates that cgr-1 positively regulates induction of vulval cell fates. cgr-1 is likely to function at a step in the Ras signaling pathway that is downstream of let-60, which encodes Ras, and upstream of lin-1, which encodes a transcription factor, if these genes function in a linear signaling pathway. These genetic studies are also consistent with the model that cgr-1 functions in a parallel pathway that promotes vulval cell fates. Localized expression studies suggest that cgr-1 functions cell autonomously to affect vulval cell fates. cgr-1 also functions early in development, since cgr-1 is necessary for larval viability. CGR-1 contains a CRAL\/TRIO domain likely to bind a small hydrophobic ligand and a GOLD domain that may mediate interactions with proteins. A bioinformatic analysis revealed that there is a conserved family of CRAL\/TRIO and GOLD domain-containing proteins that includes members from vertebrates and Drosophila. The analysis of cgr-1 identifies a novel in vivo function for a member of this family and a potential new regulator of Ras-mediated signaling.<\/jats:p>","DOI":"10.1534\/genetics.104.035550","type":"journal-article","created":{"date-parts":[[2005,10,12]],"date-time":"2005-10-12T03:23:19Z","timestamp":1129087399000},"page":"929-942","source":"Crossref","is-referenced-by-count":4,"title":["The CRAL\/TRIO and GOLD Domain Protein CGR-1 Promotes Induction of Vulval Cell Fates in <i>Caenorhabditis elegans<\/i> and Interacts Genetically With the Ras Signaling Pathway"],"prefix":"10.1093","volume":"172","author":[{"given":"Jessica L","family":"Goldstein","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Pharmacology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Glossip","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"2022010900433737200_BIB1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1126\/science.2020855","volume":"252","year":"1991","journal-title":"Science"},{"key":"2022010900433737200_BIB2","first-page":"1","volume":"3","year":"2002","journal-title":"Genome Biol."},{"key":"2022010900433737200_BIB3","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1146\/annurev.bi.56.070187.004023","volume":"56","year":"1987","journal-title":"Annu. 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