{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:36:25Z","timestamp":1760819785080},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Genome dynamics that allow pathogens to escape host immune responses are fundamental to our understanding of host-pathogen interactions. Here we present the first population-based study of the process of concerted evolution in the repetitive domain of a protein-coding gene. This gene, SOWgp, encodes the immunodominant protein in the parasitic phase of the human pathogenic fungi Coccidioides immitis and C. posadasii. We sequenced the entire gene from strains representing the geographic ranges of the two Coccidioides species. By using phylogenetic and genetic distance analyses we discovered that the repetitive part of SOWgp evolves by concerted evolution, predominantly by the mechanism of unequal crossing over. We implemented a mathematical model originally developed for multigene families to estimate the rate of homogenization and recombination of the repetitive array, and the results indicate that the pattern of concerted evolution is a result of homogenization of repeat units proceeding at a rate close to the nucleotide point mutation rate. The release of the SOWgp molecules by the pathogen during proliferation may mislead the host: we speculate that the pathogen benefits from concerted evolution of repeated domains in SOWgp by an enhanced ability to misdirect the host's immune system.<\/jats:p>","DOI":"10.1534\/genetics.105.040923","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T00:59:30Z","timestamp":1119142770000},"page":"109-117","source":"Crossref","is-referenced-by-count":28,"title":["Concerted Evolution in the Repeats of an Immunomodulating Cell Surface Protein, SOWgp, of the Human Pathogenic Fungi <i>Coccidioides immitis<\/i> and <i>C. posadasii<\/i>"],"prefix":"10.1093","volume":"171","author":[{"given":"Hanna","family":"Johannesson","sequence":"first","affiliation":[{"name":"Department of Evolution, Genomics and Systematics, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Yu","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry T","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, California 94720"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"2022010712430246400_BIB1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1101\/SQB.1979.043.01.120","volume":"43","year":"1979","journal-title":"Cold Spring Harbor Symp. 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