{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T20:46:06Z","timestamp":1698957966102},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previously, a highly significant QTL affecting fat yield and protein yield and mapped to the bovine BTA26 chromosome has been reported to segregate in the French Holstein cattle population. To confirm and refine the location of this QTL, the original detection experiment was extended by adding 12 new families and genotyping 25 additional microsatellite markers (including 11 newly developed markers). Data were then analyzed by an approach combining both linkage and linkage disequilibrium information, making it possible to identify two linked QTL separated by 20 cM corresponding to \u223c29 Mb. The presence of a QTL affecting protein yield was confirmed but its position was found to be more telomeric than the two QTLunderlying fat yield. Each identified QTL affecting milk fat yield was physically mapped within a segment estimated to be &amp;lt;500 kb. Two strong functional candidate genes involved, respectively, in fatty acid metabolism and membrane permeability were found to be localized within this segment while other functional candidate genes were discarded. A haplotype comprising the favorable allele at each QTL position appears to be overrepresented in the artificial insemination bull population.<\/jats:p>","DOI":"10.1534\/genetics.105.046169","type":"journal-article","created":{"date-parts":[[2005,9,20]],"date-time":"2005-09-20T00:38:36Z","timestamp":1127176716000},"page":"425-436","source":"Crossref","is-referenced-by-count":32,"title":["Fine Mapping and Physical Characterization of Two Linked Quantitative Trait Loci Affecting Milk Fat Yield in Dairy Cattle on BTA26"],"prefix":"10.1093","volume":"172","author":[{"given":"Mathieu","family":"Gautier","sequence":"first","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Biochimique et Cytoge\u0301ne\u0301tique and"},{"name":"Department of Animal and Aquacultural Sciences and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Roy","family":"Barcelona","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Biochimique et Cytoge\u0301ne\u0301tique and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se\u0301bastien","family":"Fritz","sequence":"additional","affiliation":[{"name":"Union Nationale des Coope\u0301ratives d'Elevage et d'Inse\u0301mination Animale, 75595 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce\u0301cile","family":"Grohs","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Biochimique et Cytoge\u0301ne\u0301tique and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Druet","sequence":"additional","affiliation":[{"name":"Station de Ge\u0301ne\u0301tique Quantitative et Applique\u0301e, INRA 78352 Jouy-en-Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Boichard","sequence":"additional","affiliation":[{"name":"Station de Ge\u0301ne\u0301tique Quantitative et Applique\u0301e, INRA 78352 Jouy-en-Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre\u0301","family":"Eggen","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Biochimique et Cytoge\u0301ne\u0301tique and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo H E","family":"Meuwissen","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences and"},{"name":"Centre for Integrative Genetics, Agricultural University of Norway, N-1432 Aas, Norway and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"2022010818051316100_BIB1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2022010818051316100_BIB2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrg1294","volume":"5","year":"2004","journal-title":"Nat. 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