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An extensive region of GON-14 contains blocks of sequence similarity to transposases of the hAT superfamily, but key residues are not conserved, suggesting a distant relationship. GON-14 also contains a putative THAP DNA-binding domain. A rescuing gon-14\u2237GON-14\u2237VENUS reporter is broadly expressed during development and localizes to the nucleus. Strong loss-of-function and predicted null gon-14 alleles have pleiotropic defects, including multivulval (Muv) defects and temperature-sensitive larval arrest. Although the gon-14 Muv defect is not enhanced by synMuv mutations, gon-14 interacts genetically with class B and class C synMuv genes, including lin-35\/Rb, let-418\/Mi-2\u03b2, and trr-1\/TRRAP. The gon-14; synMuv double mutants arrest as larvae when grown under conditions supporting development to adulthood for the respective single mutants. The gon-14 larval arrest is suppressed by loss of mes-2\/E(Z), mes-6\/ESC, or mes-4, which encodes a SET domain protein. Additionally, gon-14 affects expression of pgl-1 and lag-2, two genes regulated by the synMuv genes. We suggest that gon-14 functions with class B and class C synMuv genes to promote larval growth, in part by antagonizing MES-2,3,6\/ESC-E(z) and MES-4.<\/jats:p>","DOI":"10.1534\/genetics.105.048751","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T01:44:56Z","timestamp":1133487896000},"page":"915-928","source":"Crossref","is-referenced-by-count":26,"title":["<i>gon-14<\/i> Functions With Class B and Class C Synthetic Multivulva Genes to Control Larval Growth in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"172","author":[{"given":"Michael A","family":"Chesney","sequence":"first","affiliation":[{"name":"Department of Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Ambrose R","family":"Kidd","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kimble","sequence":"additional","affiliation":[{"name":"Department of Biochemistry"},{"name":"Program in Cellular and Molecular Biology"},{"name":"Laboratory of Genetics and"},{"name":"Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin 53706-1544"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"2022010900433859000_BIB1","year":"1995"},{"key":"2022010900433859000_BIB2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.biochem.71.110601.135400","volume":"71","year":"2002","journal-title":"Annu. 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