{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:09:21Z","timestamp":1764587361359,"version":"build-2065373602"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous genetic analysis has shown that dos\/soc-1\/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras\/Map kinase signaling through the recruitment of csw\/ptp-2\/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23\/Egfr and daf-2\/InsR (insulin receptor-like) signaling, it is shown that soc-1\/Gab1 inhibits phospholipase C-\u03b3 (PLC\u03b3) and phosphatidylinositol 3\u2032-kinase (PI3K)-mediated signaling. Furthermore, as well as stimulating Ras\/Map kinase signaling, soc-1\/Gab1 stimulates a poorly defined signaling pathway that represses class 2 daf-2 phenotypes. In addition, it is shown that SOC-1 binds the C-terminal SH3 domain of SEM-5. This binding is likely to be functional as the sem-5(n2195)G201R mutation, which disrupts SOC-1 binding, behaves in a qualitatively similar manner to a soc-1 null allele in all assays for let-23\/Egfr and daf-2\/InsR signaling that were examined. Further genetic analysis suggests that ptp-2\/Shp2 mediates the negative function of soc-1\/Gab1 in PI3K-mediated signaling, as well as the positive function in Ras\/Map kinase signaling. Other effectors of soc-1\/Gab1 are likely to inhibit PLC\u03b3-mediated signaling and stimulate the poorly defined signaling pathway that represses class 2 daf-2 phenotypes. Thus, the recruitment of soc-1\/Gab1, and its effectors, into the RTK-signaling complex modifies the cellular response by enhancing Ras\/Map kinase signaling while inhibiting PI3K and PLC\u03b3-mediated signaling.<\/jats:p>","DOI":"10.1534\/genetics.106.055822","type":"journal-article","created":{"date-parts":[[2006,3,18]],"date-time":"2006-03-18T01:25:33Z","timestamp":1142645133000},"page":"163-175","source":"Crossref","is-referenced-by-count":16,"title":["The Adaptor Protein <i>soc-1<\/i>\/Gab1 Modifies Growth Factor Receptor Output in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"173","author":[{"given":"Neil A","family":"Hopper","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2022011723451624700_BIB1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/j.1460-2075.1994.tb06269.x","volume":"13","year":"1994","journal-title":"EMBO J."},{"key":"2022011723451624700_BIB2","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1242\/dev.00497","volume":"130","year":"2003","journal-title":"Development"},{"key":"2022011723451624700_BIB3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0925-4773(99)00252-X","volume":"90","year":"2000","journal-title":"Mech. 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