{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:29:40Z","timestamp":1778840980017,"version":"3.51.4"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonself recognition is exemplified in the fungal kingdom by the regulation of cell fusion events between genetically different individuals (heterokaryosis). The het-6 locus is one of \u223c10 loci that control heterokaryon incompatibility during vegetative growth of N. crassa. Previously, it was found that het-6-associated incompatibility in Oak Ridge (OR) strains involves two contiguous genes, het-6 and un-24. The OR allele of either gene causes \u201cstrong\u201d incompatibility (cell death) when transformed into Panama (PA)-background strains. Several remarkable features of the locus include the nature of these incompatibility genes (het-6 is a member of a repetitive gene family and un-24 also encodes the large subunit of ribonucleotide reductase) and the observation that un-24 and het-6 are in severe linkage disequilibrium. Here, we identify \u201cweak\u201d (slow, aberrant growth) incompatibility activities by un-24PA and het-6PA when transformed separately into OR strains, whereas together they exhibit an additive, strong effect. We synthesized strains with the new allelic combinations un-24PA \u00a0het-6OR and un-24OR \u00a0het-6PA, which are not found in nature. These strains grow normally and have distinct nonself recognition capabilities but may have reduced fitness. Comparing the Oak Ridge and Panama het-6 regions revealed a paracentric inversion, the architecture of which provides insights into the evolution of the un-24\u2013het-6 gene complex.<\/jats:p>","DOI":"10.1534\/genetics.106.057562","type":"journal-article","created":{"date-parts":[[2006,6,5]],"date-time":"2006-06-05T00:26:55Z","timestamp":1149467215000},"page":"1991-2004","source":"Crossref","is-referenced-by-count":27,"title":["A Nonself Recognition Gene Complex in<i>Neurospora crassa<\/i>"],"prefix":"10.1093","volume":"173","author":[{"given":"Cristina O","family":"Micali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron L","family":"Smith","sequence":"additional","affiliation":[{"name":"Biology Department, Carleton University, Ottawa, Ontario K1S 5B6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"2022010800215673500_BIB1","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1073\/pnas.0306582101","volume":"101","year":"2004","journal-title":"Proc. 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