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Here we show that sel-6 and two other previously defined genes, mal-2 and emb-4, are the same gene, now called \u201cemb-4.\u201d We perform a genetic and molecular characterization of emb-4 and show that it functions cell autonomously as a positive regulator of lin-12 activity. Viable alleles identified as suppressors of lin-12 are partial loss-of-function mutations, whereas the null phenotype encompasses a range of lethal terminal phenotypes that apparently are not related to loss of lin-12\/Notch signaling. emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain and has apparent orthologs in fission yeast, plants, and animals.<\/jats:p>","DOI":"10.1534\/genetics.106.063453","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T01:03:38Z","timestamp":1160442218000},"page":"1907-1915","source":"Crossref","is-referenced-by-count":8,"title":["EMB-4: A Predicted ATPase That Facilitates<i>lin-12<\/i>Activity in<i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"174","author":[{"given":"Iskra","family":"Katic","sequence":"first","affiliation":[{"name":"Department of Genetics and Development"},{"name":"Howard Hughes Medical Institute and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and"},{"name":"Department of Biochemistry and Molecular Biophysics , Columbia University College of Physicians and Surgeons, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2023030304560859000_","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023030304560859000_","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ceb.2005.04.006","volume":"17","year":"2005","journal-title":"Curr. 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