{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:44:49Z","timestamp":1790084689673,"version":"4.0.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Female differentiation of Drosophila germ cells is induced by cell-nonautonomous signals generated in the gonadal soma that work with germ-cell-autonomous signals determined by germ-cell X chromosome dose. Generation of the nonautonomous feminizing signals was known to involve female-specific protein encoded by the master sex-determination gene Sex-lethal (Sxl) acting on its switch-gene target transformer (tra) to produce TraF protein. However, it was not known whether Sxl's action on tra alone would suffice to trigger a fully feminizing nonautonomous signal. We developed a constitutively feminizing tra transgene that allowed us to answer this question. In gynanders (XX\/\/XO mosaics) feminized by this TraF transgene, functionally Sxl\u2212 haplo-X (chromosomally male) somatic cells collaborated successfully with diplo-X (chromosomally female) germ cells to make functional eggs. The fertility of such gynanders shows not only that TraF is sufficient to elicit a fully feminizing nonautonomous signal, but also that haplo-X somatic cells can execute all other somatic functions required for oogenesis, despite the fact that their genome is not expected to be dosage compensated for such diplo-X-specific functions. The unexpected observation that some TraF-feminized gynanders failed to lay their eggs showed there to be diplo-X cells outside the gonad for which TraF-feminized haplo-X cells cannot substitute.<\/jats:p>","DOI":"10.1534\/genetics.106.066332","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T01:45:33Z","timestamp":1163727933000},"page":"631-642","source":"Crossref","is-referenced-by-count":16,"title":["<i>Drosophila melanogaster<\/i>Male Somatic Cells Feminized Solely by TraF Can Collaborate With Female Germ Cells to Make Functional Eggs"],"prefix":"10.1093","volume":"175","author":[{"given":"Daniel S","family":"Evans","sequence":"first","affiliation":[{"name":"Division of Genetics , Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W","family":"Cline","sequence":"additional","affiliation":[{"name":"Division of Genetics , Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,2,1]]},"reference":[{"key":"2023030305082152300_","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0960-9822(07)00491-5","volume":"8","year":"1998","journal-title":"Curr. 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