{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:27:56Z","timestamp":1790778476441,"version":"4.1.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vulval development in Caenorhabiditis elegans is inhibited by the redundant functions of the synthetic multivulva (synMuv) genes. At least 26 synMuv genes have been identified, many of which appear to act via transcriptional repression. Here we report the molecular identification of the class B synMuv gene lin-61, which encodes a protein composed of four malignant brain tumor (MBT) repeats. MBT repeats, domains of \u223c100 amino acids, have been found in multiple copies in a number of transcriptional repressors, including Polycomb-group proteins. MBT repeats are important for the transcriptional repression mediated by these proteins and in some cases have been shown to bind modified histones. C. elegans contains one other MBT-repeat-containing protein, MBTR-1. We demonstrate that a deletion allele of mbtr-1 does not cause a synMuv phenotype nor does mbtr-1 appear to act redundantly with or in opposition to lin-61. We further show that lin-61 is phenotypically and biochemically distinct from other class B synMuv genes. Our data indicate that while the class B synMuv genes act together to regulate vulval development, lin-61 functions separately from some class B synMuv proteins in other biological processes.<\/jats:p>","DOI":"10.1534\/genetics.106.069633","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T00:12:59Z","timestamp":1175731979000},"page":"255-271","source":"Crossref","is-referenced-by-count":40,"title":["LIN-61, One of Two<i>Caenorhabditis elegans<\/i>Malignant-Brain-Tumor-Repeat-Containing Proteins, Acts With the DRM and NuRD-Like Protein Complexes in Vulval Development but Not in Certain Other Biological Processes"],"prefix":"10.1093","volume":"176","author":[{"given":"Melissa M","family":"Harrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Robert","family":"Horvitz","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute , Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1242\/dev.02444","volume":"133","year":"2006","journal-title":"Development"},{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1038\/sj.emboj.7600654","volume":"24","year":"2005","journal-title":"EMBO J."},{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35065138","volume":"410","year":"2001","journal-title":"Nature"},{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/nar\/30.1.276","volume":"30","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/348503a0","volume":"348","year":"1990","journal-title":"Nature"},{"key":"2023030305335231500_","doi-asserted-by":"crossref","first-page":"15412","DOI":"10.1074\/jbc.M300592200","volume":"278","year":"2003","journal-title":"J. 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