{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:34:35Z","timestamp":1791045275461,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cutaneous malignant melanoma in Sinclair swine is a hereditary disease that develops in utero or during the first 6 weeks of life. In many cases, the tumors regress and piglets survive the disease. Two different sets of gene(s) might be involved in the disease: tumor initiator (suppressor) locus or loci and loci affecting the aggressiveness of the disease (number and stage of tumors). We develop maximum-likelihood methods for interval mapping for both types of loci. The experimental design consisted of a boar mated to tumor-bearing sows with recording of tumor status and number of tumors in the 6 weeks of life of the offspring. The model to search for the tumor initiator locus (with alleles T and t) was tested by computer simulation. Estimates of penetrances (\u03a8TT and \u03a8Tt for genotypes TT and Tt, respectively) were accurate even for small family sizes. Statistical power was &amp;gt;99% for a family size of 70 with \u03a8TT = 1 and \u03a8Tt = 0. The models to test for number of tumors incorporated genotype information for the tumor initiator locus. All models were tested with data from a single boar family of 72 piglets over swine chromosomes 6 and 8 (SSC6 and SSC8). No tumor evidence for initiator loci was found associated with these chromosomes. However, association of a QTL affecting number of tumors at birth near microsatellite SW1953 on SSC8 was chromosomewise significant (P &amp;lt; 0.0124).<\/jats:p>","DOI":"10.1534\/genetics.106.070268","type":"journal-article","created":{"date-parts":[[2007,5,20]],"date-time":"2007-05-20T03:58:04Z","timestamp":1179633484000},"page":"585-597","source":"Crossref","is-referenced-by-count":6,"title":["Modeling Inheritance of Malignant Melanoma With DNA Markers in Sinclair Swine"],"prefix":"10.1093","volume":"176","author":[{"given":"L","family":"Gomez-Raya","sequence":"first","affiliation":[{"name":"Department of Animal Biotechnology, University of Nevada, Reno, Nevada 89557"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Okomo-Adhiambo","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, University of Nevada, Reno, Nevada 89557"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Osborne","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, University of Nevada, Reno, Nevada 89557"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rink","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, University of Nevada, Reno, Nevada 89557"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Rauw","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, University of Nevada, Reno, Nevada 89557"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"2022011415474344500_BIB1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000133235","volume":"59","year":"1992","journal-title":"Cytogenet. 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