{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:50:34Z","timestamp":1791143434832,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mosquito Aedes aegypti is the principal vector of dengue and yellow fever flaviviruses. Permethrin is an insecticide used to suppress Ae. aegypti adult populations but metabolic and target site resistance to pyrethroids has evolved in many locations worldwide. Quantitative trait loci (QTL) controlling permethrin survival in Ae. aegypti were mapped in an F3 advanced intercross line. Parents came from a collection of mosquitoes from Isla Mujeres, Me\u0301xico, that had been selected for permethrin resistance for two generations and a reference permethrin-susceptible strain originally from New Orleans. Following a 1-hr permethrin exposure, 439 F3 adult mosquitoes were phenotyped as knockdown resistant, knocked down\/recovered, or dead. For QTL mapping, single nucleotide polymorphisms (SNPs) were identified at 22 loci with potential antixenobiotic activity including genes encoding cytochrome P450s (CYP), esterases (EST), or glutathione transferases (GST) and at 12 previously mapped loci. Seven antixenobiotic genes mapped to chromosome I, six to chromosome II, and nine to chromosome III. Two QTL of major effect were detected on chromosome III. One corresponds with a SNP previously associated with permethrin resistance in the para sodium channel gene and the second with the CCEunk7o esterase marker. Additional QTL but of relatively minor effect were also found. These included two sex-linked QTL on chromosome I affecting knockdown and recovery and a QTL affecting survival and recovery. On chromosome II, one QTL affecting survival and a second affecting recovery were detected. The patterns confirm that mutations in the para gene cause target-site insensitivity and are the major source of permethrin resistance but that other genes dispersed throughout the genome contribute to recovery and survival of mosquitoes following permethrin exposure.<\/jats:p>","DOI":"10.1534\/genetics.108.087924","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T00:12:40Z","timestamp":1219709560000},"page":"1137-1152","source":"Crossref","is-referenced-by-count":81,"title":["Quantitative Trait Loci Mapping of Genome Regions Controlling Permethrin Resistance in the Mosquito <i>Aedes aegypti<\/i>"],"prefix":"10.1093","volume":"180","author":[{"given":"Karla","family":"Saavedra-Rodriguez","sequence":"first","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523-1685"},{"name":"Laboratorio de Entomologia Medica, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, 66451 Me\u0301xico, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Strode","sequence":"additional","affiliation":[{"name":"Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Flores Suarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Entomologia Medica, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, 66451 Me\u0301xico, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildefonso","family":"Fernandez Salas","sequence":"additional","affiliation":[{"name":"Laboratorio de Entomologia Medica, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, 66451 Me\u0301xico, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Ranson","sequence":"additional","affiliation":[{"name":"Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Hemingway","sequence":"additional","affiliation":[{"name":"Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"William C","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523-1685"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"2022011118250118200_BIB1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/jmedent\/43.6.1185","volume":"43","year":"2006","journal-title":"J. Med. Entomol."},{"key":"2022011118250118200_BIB2","year":"1997"},{"key":"2022011118250118200_BIB3","year":"2004"},{"key":"2022011118250118200_BIB4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3201\/eid0404.980410","volume":"4","year":"1998","journal-title":"Emerging Infect. Dis."},{"key":"2022011118250118200_BIB5","first-page":"159","volume":"14","year":"1998","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"2022011118250118200_BIB6","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1073\/pnas.0409348102","volume":"102","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022011118250118200_BIB7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/hdy.1991.33","volume":"66","year":"1991","journal-title":"Heredity"},{"key":"2022011118250118200_BIB8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/jee\/83.3.647","volume":"83","year":"1990","journal-title":"J. Econ. Entomol."},{"key":"2022011118250118200_BIB9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pestbp.2004.12.007","volume":"82","year":"2005","journal-title":"Pest. Biochem. Physiol."},{"key":"2022011118250118200_BIB10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2987\/8756-971X(2006)22[672:MOIRIF]2.0.CO;2","volume":"22","year":"2006","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"2022011118250118200_BIB11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/genetics\/158.2.715","volume":"158","year":"2001","journal-title":"Genetics"},{"key":"2022011118250118200_BIB12","first-page":"175","volume":"33","year":"1947","journal-title":"Hereditas"},{"key":"2022011118250118200_BIB13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.0962-1075.2004.00522.x","volume":"13","year":"2004","journal-title":"Insect Mol. Biol."},{"key":"2022011118250118200_BIB14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2583.2003.00401.x","volume":"12","year":"2003","journal-title":"Insect Mol. Biol."},{"key":"2022011118250118200_BIB15","first-page":"221","volume":"17","year":"2005","journal-title":"Rev. Panam. Salud Publica-Panamer. J. Publ Health"},{"key":"2022011118250118200_BIB16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.hdy.6885370","volume":"83","year":"1999","journal-title":"Heredity"},{"key":"2022011118250118200_BIB17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1603\/0022-0493-96.4.1021","volume":"96","year":"2003","journal-title":"J. Econ. Entomol."},{"key":"2022011118250118200_BIB18","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1093\/jee\/99.4.1388","volume":"99","year":"2006","journal-title":"J. Econ. Entomol."},{"key":"2022011118250118200_BIB19","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/genetics\/152.3.1203","volume":"152","year":"1999","journal-title":"Genetics"},{"key":"2022011118250118200_BIB20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1469-1809.1943.tb02321.x","volume":"12","year":"1943","journal-title":"Ann. Eugen."},{"key":"2022011118250118200_BIB21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/g93-001","volume":"36","year":"1993","journal-title":"Genome"},{"key":"2022011118250118200_BIB22","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1126\/science.1138878","volume":"316","year":"2007","journal-title":"Science"},{"key":"2022011118250118200_BIB23","year":"2003"},{"key":"2022011118250118200_BIB24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/gb-2003-4-1-202","volume":"4","year":"2003","journal-title":"Genome Biol."},{"key":"2022011118250118200_BIB25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj3460017","volume":"346","year":"2000","journal-title":"Biochem. J."},{"key":"2022011118250118200_BIB26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/pmic.200400914","volume":"5","year":"2005","journal-title":"Proteomics"},{"key":"2022011118250118200_BIB27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2583.2000.00214.x","volume":"9","year":"2000","journal-title":"Insect Mol. Biol."},{"key":"2022011118250118200_BIB28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.0962-1075.2004.00495.x","volume":"13","year":"2004","journal-title":"Insect Mol. Biol."},{"key":"2022011118250118200_BIB29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1603\/0022-2585-38.5.623","volume":"38","year":"2001","journal-title":"J. Med. Entomol."},{"key":"2022011118250118200_BIB30","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1603\/0022-2585-39.6.882","volume":"39","year":"2002","journal-title":"J. Med. Entomol."},{"key":"2022011118250118200_BIB31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2987\/8756-971X(2006)21[437:PISOAA]2.0.CO;2","volume":"21","year":"2005","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"2022011118250118200_BIB32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0169-4758(93)90141-2","volume":"9","year":"1993","journal-title":"Parasitol. Today"},{"key":"2022011118250118200_BIB33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.en.32.010187.002045","volume":"32","year":"1987","journal-title":"Annu. Rev. Entomol."},{"key":"2022011118250118200_BIB34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1365-2583.2007.00774.x","volume":"16","year":"2007","journal-title":"Insect Mol. Biol."},{"key":"2022011118250118200_BIB35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/oxfordjournals.jhered.a023148","volume":"88","year":"1997","journal-title":"J. Hered."},{"key":"2022011118250118200_BIB36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0965-1748(03)00023-7","volume":"33","year":"2003","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2022011118250118200_BIB37","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-313X.1993.00739.x","volume":"3","year":"1993","journal-title":"Plant J."},{"key":"2022011118250118200_BIB38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ibmb.2007.09.007","volume":"38","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2022011118250118200_BIB39","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","volume":"22","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"2022011118250118200_BIB40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2583.2007.00728.x","volume":"16","year":"2007","journal-title":"Insect Mol. Biol."},{"key":"2022011118250118200_BIB41","year":"2007"},{"key":"2022011118250118200_BIB42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2164-8-5","volume":"8","year":"2007","journal-title":"BMC Genomics"},{"key":"2022011118250118200_BIB43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2164-8-34","volume":"8","year":"2007","journal-title":"BMC Genomics"},{"key":"2022011118250118200_BIB44","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/genetics\/136.4.1457","volume":"136","year":"1994","journal-title":"Genetics"}],"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/180\/2\/1137\/42096079\/genetics1137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/180\/2\/1137\/42096079\/genetics1137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:05:23Z","timestamp":1641931523000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/180\/2\/1137\/6073714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,1]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,10,1]]},"published-print":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1534\/genetics.108.087924","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,10,1]]},"published":{"date-parts":[[2008,10,1]]}}}