{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:23:59Z","timestamp":1761708239302},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mutational input of genetic variance per generation ($\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{m}}^{2}\\) \\end{document}$) is the lower limit of the genetic variability in inbred strains of mice, although greater values could be expected due to the accumulation of new mutations in successive generations. A mixed-model analysis using Bayesian methods was applied to estimate $\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{m}}^{2}\\) \\end{document}$ and the across-generation accumulated genetic variability on litter size in 46 generations of a C57BL\/6J inbred strain. This allowed for a separate inference on $\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{m}}^{2}\\) \\end{document}$ and on the additive genetic variance in the base population ($\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{a}}^{2}\\) \\end{document}$). The additive genetic variance in the base generation was 0.151 and quickly decreased to almost null estimates in generation 10. On the other hand, $\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{m}}^{2}\\) \\end{document}$ was moderate (0.035) and the within-generation mutational variance increased up to generation 14, then oscillating between 0.102 and 0.234 in remaining generations. This pattern suggested the existence of a continuous uploading of genetic variability for litter size ($\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(h^{2}{=}0.045\\) \\end{document}$). Relevant genetic drift was not detected in this population. In conclusion, our approach allowed for separate estimation of $\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{a}}^{2}\\) \\end{document}$ and $\\batchmode \\documentclass[fleqn,10pt,legalpaper]{article} \\usepackage{amssymb} \\usepackage{amsfonts} \\usepackage{amsmath} \\pagestyle{empty} \\begin{document} \\(\\mathrm{{\\sigma}}_{\\mathrm{m}}^{2}\\) \\end{document}$ within the mixed-model framework, and the heritability obtained highlighted the significant and continuous influence of new genetic variability affecting the genetic stability of inbred strains.<\/jats:p>","DOI":"10.1534\/genetics.108.088070","type":"journal-article","created":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T00:13:07Z","timestamp":1217290387000},"page":"2147-2155","source":"Crossref","is-referenced-by-count":21,"title":["Within-Generation Mutation Variance for Litter Size in Inbred Mice"],"prefix":"10.1093","volume":"179","author":[{"given":"Joaquim","family":"Casellas","sequence":"first","affiliation":[{"name":"Gene\u0300tica i Millora Animal, Institut de Recerca i Tecnologia Agroalimenta\u0300ries-Lleida, 25198 Lleida, Spain and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F","family":"Medrano","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of California, Davis, California 95616-8521"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"2022011118262212200_BIB1","year":"1977"},{"key":"2022011118262212200_BIB2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0167-5699(82)90093-7","volume":"3","year":"1982","journal-title":"Immunol. 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