{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:10:03Z","timestamp":1709183403659},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The medaka, Oryzias latipes, has an XX\/XY sex-determination system, and a Y-linked DM-domain gene, DMY, is the sex-determining gene in this species. Since DMY appears to have arisen from a duplicated copy of the autosomal DMRT1 gene \u223c10 million years ago, the medaka Y chromosome is considered to be one of the youngest male-determining chromosomes in vertebrates. In the screening process of sex-reversal mutants from wild populations, we found a population that contained a number of XY females. PCR, direct sequencing, and RT\u2013PCR analyses revealed two different null DMY mutations in this population. One mutation caused loss of expression during the sex-determining period, while the other comprised a large deletion in putative functional domains. YY females with the mutant-type DMY genes on their Y chromosomes were fully fertile, indicating that the X and Y chromosomes were functionally the same except for the male-determining function. In addition, we investigated the frequencies of the sex chromosome types in this population over four successive generations. The Y chromosomes bearing the mutant-type DMY genes were detected every year with no significant differences in their frequencies. These results demonstrate that aberrant Y chromosomes behaving as X chromosomes have been maintained in this population.<\/jats:p>","DOI":"10.1534\/genetics.108.090167","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T00:34:39Z","timestamp":1218328479000},"page":"2157-2162","source":"Crossref","is-referenced-by-count":12,"title":["The Y Chromosome That Lost the Male-Determining Function Behaves as an X Chromosome in the Medaka Fish,<i>Oryzias latipes<\/i>"],"prefix":"10.1093","volume":"179","author":[{"given":"Hiroyuki","family":"Otake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata 950-2181, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Sakaizumi","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata 950-2181, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"2022011118263324600_BIB2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/0470868732.ch9","volume":"244","year":"2002","journal-title":"Novartis Found. 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