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In Caenorhabditis elegans, the class A and B synthetic multivulva (synMuv) genes redundantly repress expression of lin-3 EGF to negatively regulate Ras-mediated vulval development. The class B synMuv genes encode proteins homologous to components of the NuRD and Myb-MuvB\/dREAM transcriptional repressor complexes, indicating that they likely silence lin-3 EGF through chromatin remodeling. The two class A synMuv genes cloned thus far, lin-8 and lin-15A, both encode novel proteins. The LIN-8 protein is nuclear. We have characterized the class A synMuv gene lin-56 and found it to encode a novel protein that shares a THAP-like C2CH motif with LIN-15A. Both the LIN-56 and LIN-15A proteins localize to nuclei. Wild-type levels of LIN-56 require LIN-15A, and wild-type levels and\/or localization of LIN-15A requires LIN-56. Furthermore, LIN-56 and LIN-15A interact in the yeast two-hybrid system. We propose that LIN-56 and LIN-15A associate in a nuclear complex that inhibits vulval specification by repressing lin-3 EGF expression.<\/jats:p>","DOI":"10.1534\/genetics.110.124487","type":"journal-article","created":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T02:36:58Z","timestamp":1293849418000},"page":"803-815","source":"Crossref","is-referenced-by-count":13,"title":["The LIN-15A and LIN-56 Transcriptional Regulators Interact to Negatively Regulate EGF\/Ras Signaling in<i>Caenorhabditis elegans<\/i>Vulval Cell-Fate Determination"],"prefix":"10.1093","volume":"187","author":[{"given":"Ewa M","family":"Davison","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute , Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M","family":"Saffer","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute , Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"Huang","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"DeModena","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Robert","family":"Horvitz","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute , Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1242\/dev.009373","volume":"134","year":"2007","journal-title":"Development"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1534\/genetics.108.092197","volume":"179","year":"2008","journal-title":"Genetics"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/348693a0","volume":"348","year":"1990","journal-title":"Nature"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/348503a0","volume":"348","year":"1990","journal-title":"Nature"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-1119(00)00296-1","volume":"254","year":"2000","journal-title":"Gene"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1017\/S1355838202028595","volume":"8","year":"2002","journal-title":"RNA"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature00831","volume":"417","year":"2002","journal-title":"Nature"},{"key":"2023030719405612400_","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0960-9822(02)00844-8","volume":"12","year":"2002","journal-title":"Curr. 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